DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment phm and cyp-36A1

DIOPT Version :9

Sequence 1:	NP_001285414.1	Gene:	phm / 32857	FlyBaseID:	FBgn0004959	Length:	574	Species:	Drosophila melanogaster
Sequence 2:	NP_492267.1	Gene:	cyp-36A1 / 183193	WormBaseID:	WBGene00007913	Length:	493	Species:	Caenorhabditis elegans

Alignment Length:	571	Identity:	142/571 - (24%)
Similarity:	248/571 - (43%)	Gaps:	120/571 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 ILLVPGALVLVILYLCERQCNDLMGAPP-PGPWGLPFLGYLPFLDARAPHKSLQKLAKRYGGIFE 85
            ::||    ::|:|:|| |..|.|.|.|| |.||  ||:|....:........:.:..|:|||||.
Worm     7 VILV----IIVMLFLC-RFANKLRGLPPGPTPW--PFIGNTFQVPEDRIDLIINEFKKKYGGIFT 64

  Fly    86 LKMGRVPTVVLSDAALVRDFFRRDVM------TGRAPLYLTHG-IMGGFGIICAQEDIWRHARRE 143
            |.: ..||:|:.|    .|..:|:::      :||...::... :.|.:|:...:.:.|:..||.
Worm    65 LWL-PFPTIVICD----YDMLKRNIVKNGESFSGRPDTFIMDMLVQGNYGLFFMENNWWKAQRRF 124

  Fly   144 TIDWLKALGMTRRPGELRARLERRIARGVDECVRLFDTEAKKSCASEVNPLPALHHSLGNIINDL 208
            |....::||:.      :|..:..||......|...|.:..|..  |:.||  |.|.:||:|:..
Worm   125 TTHIFRSLGVG------QAGTQDTIASLASGLVEKIDGQKDKPI--ELRPL--LVHVVGNVIHKH 179

  Fly   209 VFGITYKRDDPDWL--------YLQRLQEEGVKLIGVSGVVNFLPWLRHL--PANVRNIRFLLEG 263
            :||.|.:.::.:.|        .|:.......:|:      :..|||.:|  |.::        |
Worm   180 LFGFTREWNETEILDFHVAINDVLEHFTSPKTQLL------DAWPWLAYLDKPLSL--------G 230

  Fly   264 KAKTHAIYDRIVEACGQRLKEKQKVFKELQEQKRLQRQLEKEQLRQSKEADPSQEQSEADEDDEE 328
            ..:|....|.|::...|.|                                 ::.::..:.|:|.
Worm   231 IPRTTRANDAIIQNLEQAL---------------------------------AKHKTGINYDEEP 262

  Fly   329 SDEEDTYEPECILEHFLAVRDTDSQL---YCDDQLRHLLADLFGAGVDTSLATLRWFLLYLAREQ 390
            |...|.:..|      :.:|..::.|   :.:.||...:.||:.||::|.:..||:..|||....
Worm   263 SSYMDAFLKE------MKIRAAENALEDGFTEKQLIVAIYDLYSAGMETIIIVLRFAFLYLVNNP 321

  Fly   391 RCQRRLHELL---LPLGPSPTLEELEPLAYLRACISETMRIRSVVPLGIPHGCKENFV------V 446
            ..|:|:||.|   :.......:::.:.|.|..|.:.|..|:..|:|:        ||:      |
Worm   322 ETQKRIHEELDRNVGRERQVVMDDQKHLPYTCAFLQEVYRLGYVLPV--------NFLRCTLTDV 378

  Fly   447 GD---YFIKGGSMIVCSEWAIHMDPVAFPEPEEFRPERFLTADGAYQAPPQFIPFSSGYRMCPGE 508
            .|   |.:..|:.::....::|:|...||:||.|.|:|||.:.|.|....:..|||.|.|.|.||
Worm   379 EDCEGYRLNAGTRVIAQFQSVHVDKKHFPDPEHFNPDRFLNSRGEYIRDDRVNPFSMGKRSCLGE 443

  Fly   509 EMARMILTLFTGRILRRF--HLELPSGTEVDMAGESGITLTPTPHMLRFTK 557
            .:|||.:.|:...:::.|  |.:.|....:|:...|  ...|.|..:|.::
Worm   444 NLARMEVFLYFCTLMQNFEWHTDGPYAPPIDVITSS--LRAPKPFTVRASR 492

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
phm	NP_001285414.1	p450	49..555	CDD:278495	130/540 (24%)
cyp-36A1	NP_492267.1	p450	28..488	CDD:278495	131/539 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000008
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.000