DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment phm and Cyp2c13

DIOPT Version :9

Sequence 1:	NP_001285414.1	Gene:	phm / 32857	FlyBaseID:	FBgn0004959	Length:	574	Species:	Drosophila melanogaster
Sequence 2:	NP_612523.1	Gene:	Cyp2c13 / 171521	RGDID:	620363	Length:	490	Species:	Rattus norvegicus

Alignment Length:	549	Identity:	145/549 - (26%)
Similarity:	231/549 - (42%)	Gaps:	87/549 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 ILYLCERQCNDLMGAPPPGPWGLPFLGYLPFLDARAPHKSLQKLAKRYGGIFELKMGRVPTVVLS 97
            :|:|...:.:...|..||||..||.:|....:|.:...:||...:|.||.::.|.:|..|||||.
  Rat    14 LLFLSLWRLSSGRGKLPPGPTPLPIIGNFFQVDMKDIRQSLTNFSKTYGPVYTLYVGSQPTVVLH 78

  Fly    98 DAALVRDFF--RRDVMTGRAPLYLTHGIMGGFGIICAQEDIWRHARRETIDWLKALGMTRRPGEL 160
            ....:::..  ..:..:||..|.:...:..|.||..:..::|:..|..|:..|:.|||.:  |.:
  Rat    79 GYEALKEALVDHGEEFSGRGRLPICEKVAKGQGIAFSHGNVWKATRHFTVKTLRNLGMGK--GTI 141

  Fly   161 RARLERRIARGVDECVRLFDTEAKKSCASEVNPLPALHHSLGNIINDLVFGITYKRDDPDWLYLQ 225
            ..:        |.|..:....|.||:..|..:|...:..:.||:|..::....:..:|.|:|.|.
  Rat   142 EDK--------VQEEAKWLVKELKKTNGSPCDPQFIMGCAPGNVICCIILQNRFDYEDKDFLNLI 198

  Fly   226 RLQEEGVKLIGVSG--VVNFLP-WLRHLPANVRNIRFLLEGKAKTHAIYDRIVEACGQRLKEKQK 287
            ....|.||:|...|  |.|..| .|.:.|.|              |.||          ||....
  Rat   199 EKVNEAVKIISSPGIQVFNIFPILLDYCPGN--------------HNIY----------LKNYTW 239

  Fly   288 VFKELQEQKRLQRQLEKEQLRQSKEADPSQEQSEADEDDEESDEEDTYEPECILEHFLAVRDTDS 352
            |...|.|:.:                             |..:..|...|...:::||..|:.::
  Rat   240 VKSYLLEKIK-----------------------------EHEESLDVSNPRDFIDYFLIERNQEN 275

  Fly   353 ----QLYCDDQLRHLLADLFGAGVDTSLATLRWFLLYLAREQRCQRRLHELL---LPLGPSPTLE 410
                ..|..:.|..::.|||.||::|..:|:|:.||.|.:......::.|.:   :....||:::
  Rat   276 ANQWMNYTLEHLAIMVTDLFFAGIETVSSTMRFALLLLMKYPHVTAKVQEEIDHVIGRHRSPSMQ 340

  Fly   411 ELEPLAYLRACISETMRIRSVVPLGIPHG--CKENFVVGDYFIKGGSMIVCSEWAIHMDPVAFPE 473
            :...:.|..|.:.|..|...:.|.|:.|.  |...|  .:|||..|:.::.|..::..|...||.
  Rat   341 DRSHMPYTNAMVHEVQRYIDIGPNGLLHDVTCDTKF--RNYFIPKGTAVLTSLTSVLHDSKEFPN 403

  Fly   474 PEEFRPERFLTADGAYQAPPQFIPFSSGYRMCPGEEMARMILTLFTGRILRRFHLELPSGTEVDM 538
            ||.|.|..||..:|.::....|||||:|.|||.||.:|||.|.||...||:.|.|:       .:
  Rat   404 PEMFDPGHFLDENGNFKKSDYFIPFSAGKRMCLGESLARMELFLFLTTILQNFKLK-------SL 461

  Fly   539 AGESGITLTPTPHMLRFTKLPAVEMRHAP 567
            .....|..||....|.... |..:||..|
  Rat   462 VDPKDINTTPICSSLSSVP-PTFQMRFIP 489

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
phm	NP_001285414.1	p450	49..555	CDD:278495	138/519 (27%)
Cyp2c13	NP_612523.1	p450	30..487	CDD:278495	140/529 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000008
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.910