Protein Alignment phtm and CYP21A2

DIOPT Version :10

• Sequence 1: NP_573319.1
• Gene: phtm / 32857
• FlyBaseID: FBgn0004959
• Length: 574
• Species: Drosophila melanogaster
• Sequence 2: NP_000491.4
• Gene: CYP21A2 / 1589
• HGNCID: 2600
• Length: 495
• Species: Homo sapiens
• Alignment Length: 617
• Identity: 146/617 - (23%)
• Similarity: 227/617 - (36%)
• Gaps: 202/617 - (32%)

  Fly    23 LLVPGALVLVILYLCERQCNDLMGA--------------PPPGPWGLPFLGYLPFLDARAPHKSL 73
            :|:.|.|:|:.|         |.||              ||..|      |:|..|....| ..|
Human     1 MLLLGLLLLLPL---------LAGARLLWNWWKLRSLHLPPLAP------GFLHLLQPDLP-IYL 49

  Fly    74 QKLAKRYGGIFELKMGRVPTVVLS-----DAALVR---DFFRRDVMTGRAPLYLTHGI------- 123
            ..|.:::|.|:.|.:|....|||:     :.|:|:   ||      .|| |..||:.:
Human    50 LGLTQKFGPIYRLHLGLQDVVVLNSKRTIEEAMVKKWADF------AGR-PEPLTYKLVSRNYPD 107

  Fly   124 --MGGFGIICAQEDIWRHARRETIDWLKALGMTRRPGELRARLERRIARGVDECVRLFDTEAKKS 186
              :|.:.:      :|:..::.|                |:.|...|...::..|.....|..:.
Human   108 LSLGDYSL------LWKAHKKLT----------------RSALLLGIRDSMEPVVEQLTQEFCER 150

  Fly   187 CASEVNPLPALHHSLG----NIINDLVFGITYKRDDPDWLYLQRLQEE-------GVKLIGVSGV 240
            ..::.....|:.....    :||..|.||...|.|:....|.:.:||.       .::::.|
Human   151 MRAQPGTPVAIEEEFSLLTCSIICYLTFGDKIKDDNLMPAYYKCIQEVLKTWSHWSIQIVDV--- 212

  Fly   241 VNFLPWLRHLP-ANVRNIRFLLEGKAKTHAIYDRIVEACGQRLKEKQKVFKELQEQKRLQRQLEK 304
               :|:||..| ..:|.::..:|.:       |.|||.
Human   213 ---IPFLRFFPNPGLRRLKQAIEKR-------DHIVEM--------------------------- 240

  Fly   305 EQLRQSKE------------------ADPSQEQSEADEDDEESDEEDTYEPECILE---HFLAVR 348
             ||||.||                  |.||.|:....                :||   |..||
Human   241 -QLRQHKESLVAGQWRDMMDYMLQGVAQPSMEEGSGQ----------------LLEGHVHMAAV- 287

  Fly   349 DTDSQLYCDDQLRHLLADLFGAGVDTSLATLRWFLLYLAREQRCQRRLHELL-LPLGPSPT---- 408
                             ||...|.:|:..||.|.:::|......|:||.|.| ..|||..:
Human   288 -----------------DLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRV 335

  Fly   409 -LEELEPLAYLRACISETMRIRSVVPLGIPHGCKENFVVGDYFIKGGSMIVCSEWAIHMDPVAFP 472
             .::...|..|.|.|:|.:|:|.||||.:||.......:..|.|..|::|:.:....|:|...:.
Human   336 PYKDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWE 400

  Fly   473 EPEEFRPERFLTADGAYQAPPQFIPFSSGYRMCPGEEMARMILTLFTGRILRRFHLELPSGTEVD 537
            .|.||.|:|||......:|    :.|..|.|:|.||.:||:.|.:...|:|:.|.| ||||..:.
Human   401 RPHEFWPDRFLEPGKNSRA----LAFGCGARVCLGEPLARLELFVVLTRLLQAFTL-LPSGDALP 460

  Fly   538 MAGESGITLTPTPHMLRFTKLPAVEMRHAPDG 569
                   :|.|.||.....|:...::|..|.|
Human   461 -------SLQPLPHCSVILKMQPFQVRLQPRG 485

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
phtm	NP_573319.1	CYP306A1-like	81..553	CDD:410745	125/527 (24%)
CYP21A2	NP_000491.4	CYP21	56..482	CDD:410767	127/541 (23%)