Protein Alignment phtm and CYP17A1

DIOPT Version :10

• Sequence 1: NP_573319.1
• Gene: phtm / 32857
• FlyBaseID: FBgn0004959
• Length: 574
• Species: Drosophila melanogaster
• Sequence 2: NP_000093.1
• Gene: CYP17A1 / 1586
• HGNCID: 2593
• Length: 508
• Species: Homo sapiens
• Alignment Length: 542
• Identity: 135/542 - (24%)
• Similarity: 237/542 - (43%)
• Gaps: 108/542 - (19%)

  Fly    20 LSILLVPGALVLVILYLCERQCNDLMGAP-PPGPWGLPFLGYLPFLDARA-PHKSLQKLAKRYGG 82
            :::||    |.|..|:..:|:|   .||. |.....||.:|.||||.... .|.:..||.|:||.
Human     5 VALLL----LTLAYLFWPKRRC---PGAKYPKSLLSLPLVGSLPFLPRHGHMHNNFFKLQKKYGP 62

  Fly    83 IFELKMGRVPTVVLSDAALVRDFFRRDVMTGRAPLYLTHGIMGGFGIICAQEDIWRHARRETIDW 147
            |:.::||...||::....|.::.                       :|...:|.....:..|:|
Human    63 IYSVRMGTKTTVIVGHHQLAKEV-----------------------LIKKGKDFSGRPQMATLD- 103

  Fly   148 LKALGMTRRPGELRA------RLERRIARGVDECVRLFDTEAKKSCASEVNPL---PALHH---- 199
               :....|.|...|      :|.||:|.......:..|.:.:|....|::.|   .|.|:
Human   104 ---IASNNRKGIAFADSGAHWQLHRRLAMATFALFKDGDQKLEKIICQEISTLCDMLATHNGQSI 165

  Fly   200 --------SLGNIINDLVFGITYKRDDPDWLYLQRLQEEGVKLIGVSGVVNFLPWLRHLPANVRN 256
                    ::.|:|:.:.|..:||..||:...:|...|..:..:....:|:.:|||:..|
Human   166 DISFPVFVAVTNVISLICFNTSYKNGDPELNVIQNYNEGIIDNLSKDSLVDLVPWLKIFP----- 225

  Fly   257 IRFLLEGKAKTHAIYDRIVEACGQRLKEKQKVFKELQEQKRLQRQLE--KEQLRQSKEADPSQEQ 319
                           ::.:|    :||...|:..:|     |.:.||  ||:.|.....:.....
Human   226 ---------------NKTLE----KLKSHVKIRNDL-----LNKILENYKEKFRSDSITNMLDTL 266

  Fly   320 SEADEDDEESDEEDTYEPECILEHFLAVRDTDSQLYCDDQLRHLLADLFGAGVDTSLATLRWFLL 384
            .:|..:.:..:               |..|.||:|..|:.:...:.|:|||||:|:.:.::|.|.
Human   267 MQAKMNSDNGN---------------AGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWTLA 316

  Fly   385 YLAREQRCQRRLHELL---LPLGPSPTLEELEPLAYLRACISETMRIRSVVPLGIPHGCKENFVV 446
            :|....:.:::|:|.:   :....:||:.:...|..|.|.|.|.:|:|.|.|:.|||....:..:
Human   317 FLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSI 381

  Fly   447 GDYFIKGGSMIVCSEWAIHMDPVAFPEPEEFRPERFLTADGAYQAPP--QFIPFSSGYRMCPGEE 509
            |::.:..|:.::.:.||:|.:...:.:|::|.|||||...|.....|  .::||.:|.|.|.||.
Human   382 GEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEI 446

  Fly   510 MARMILTLFTGRILRRFHLELP 531
            :||..|.|....:|:||.||:|
Human   447 LARQELFLIMAWLLQRFDLEVP 468

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
phtm	NP_573319.1	CYP306A1-like	81..553	CDD:410745	113/479 (24%)
CYP17A1	NP_000093.1	CYP17A1	60..491	CDD:410766	114/480 (24%)