Protein Alignment phtm and CYP2F1

DIOPT Version :10

• Sequence 1: NP_573319.1
• Gene: phtm / 32857
• FlyBaseID: FBgn0004959
• Length: 574
• Species: Drosophila melanogaster
• Sequence 2: NP_000765.2
• Gene: CYP2F1 / 1572
• HGNCID: 2632
• Length: 491
• Species: Homo sapiens
• Alignment Length: 565
• Identity: 155/565 - (27%)
• Similarity: 239/565 - (42%)
• Gaps: 104/565 - (18%)

  Fly    14 MPSVQSLSILLVPGALVLVILYLCERQCNDLMGAPPPGPWGLPFLGYLPFLDARAPHKSLQKLAK 78
            |.|: |.:|||:..|||.::|.|..|.    .|..||||..|..||.|..|.::....||.||:|
Human     1 MDSI-STAILLLLLALVCLLLTLSSRD----KGKLPPGPRPLSILGNLLLLCSQDMLTSLTKLSK 60

  Fly    79 RYGGIFELKMGRVPTVVLSDAALVRDFF--RRDVMTGRAPLYLTHGIMGGFGIICAQEDIWRHAR 141
            .||.::.:.:|....||||....|::..  :.:..:||...........|.||..:..|.|:..|
Human    61 EYGSMYTVHLGPRRVVVLSGYQAVKEALVDQGEEFSGRGDYPAFFNFTKGNGIAFSSGDRWKVLR 125

  Fly   142 RETIDWLKALGMTRRPGELRARLERRIARGVDECVRLFDTEAKKSCASEVNPLPALHHSLGNIIN 206
            :.:|..|:..||.:|      .:|.||   ::|...|. .|.:|:.....:|...|..|:.|||.
Human   126 QFSIQILRNFGMGKR------SIEERI---LEEGSFLL-AELRKTEGEPFDPTFVLSRSVSNIIC 180

  Fly   207 DLVFGITYKRDDPDWLYLQRLQEEGVKLIGVSGVVNFLPW----------LRHLPA-------NV 254
            .::||..:..||...|.:.||..:..:::.       .||          |..:|.       |.
Human   181 SVLFGSRFDYDDERLLTIIRLINDNFQIMS-------SPWGELYDIFPSLLDWVPGPHQRIFQNF 238

  Fly   255 RNIRFLLEGKAKTHAIYDRIVEACGQRLKEKQKVFKELQEQKRLQRQLEKEQLRQSKEADPSQEQ 319
            :.:|.|:     .|:::|.            |........:..:|..|.|  :.:.|| ||
Human   239 KCLRDLI-----AHSVHDH------------QASLDPRSPRDFIQCFLTK--MAEEKE-DP---- 279

  Fly   320 SEADEDDEESDEEDTYEPECILEHFLAVRDTDSQLYCDDQLRHLLADLFGAGVDTSLATLRWFLL 384
                                 |.||    ..|:.|.....|      ||| |..|...||....|
Human   280 ---------------------LSHF----HMDTLLMTTHNL------LFG-GTKTVSTTLHHAFL 312

  Fly   385 YLAREQRCQRRLHE---LLLPLGPSPTLEELEPLAYLRACISETMRIRSVVPLGIPHGCKENFVV 446
            .|.:..:.|.|:.|   |::.....|.|::...:.|..|.|.|..|...::|:.:||....:...
Human   313 ALMKYPKVQARVQEEIDLVVGRARLPALKDRAAMPYTDAVIHEVQRFADIIPMNLPHRVTRDTAF 377

  Fly   447 GDYFIKGGSMIVCSEWAIHMDPVAFPEPEEFRPERFLTADGAYQAPPQFIPFSSGYRMCPGEEMA 511
            ..:.|..|:.::.....:|.||..|..|:||.||.||.|:.:::..|.|:|||:|.|:|.||.:|
Human   378 RGFLIPKGTDVITLLNTVHYDPSQFLTPQEFNPEHFLDANQSFKKSPAFMPFSAGRRLCLGESLA 442

  Fly   512 RMILTLFTGRILRRFHLELPSGT--EVDMAG-ESGITLTPTPHML 553
            ||.|.|:...||:.|.|: |.|.  ::|:.. .||:...|.|..|
Human   443 RMELFLYLTAILQSFSLQ-PLGAPEDIDLTPLSSGLGNLPRPFQL 486

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
phtm	NP_573319.1	CYP306A1-like	81..553	CDD:410745	126/496 (25%)
CYP2F1	NP_000765.2	Cyp2F	62..486	CDD:410762	127/497 (26%)