Protein Alignment phm and CYP2D6

DIOPT Version :9

• Sequence 1: NP_001285414.1
• Gene: phm / 32857
• FlyBaseID: FBgn0004959
• Length: 574
• Species: Drosophila melanogaster
• Sequence 2: NP_000097.3
• Gene: CYP2D6 / 1565
• HGNCID: 2625
• Length: 497
• Species: Homo sapiens
• Alignment Length: 564
• Identity: 158/564 - (28%)
• Similarity: 239/564 - (42%)
• Gaps: 111/564 - (19%)

  Fly    24 LVPGALVLVILYLCERQCNDLM-------GAPPPGPWGLPFLGYLPFLDARAPHKSLQKLAKRYG 81
            |||.|:::.|..|..    |||       ...||||..||.||.|..:|.:.......:|.:|:|
Human     6 LVPLAVIVAIFLLLV----DLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQLRRRFG 66

  Fly    82 GIFELKMGRVPTVVLSDAALVRDFF--RRDVMTGRAPLYLTHGIMGGFG------IICAQEDIWR 138
            .:|.|::...|.|||:..|.||:..  ..:....|.|:.:|..:  |||      .:......||
Human    67 DVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQIL--GFGPRSQGVFLARYGPAWR 129

  Fly   139 HARRETIDWLKALGMTRRPGELRARLERRIARGVDECVRLFDTEAKKSCASEVN-------PLPA 196
            ..||.::..|:.||:.::      .||:.:..           ||...||:..|       |...
Human   130 EQRRFSVSTLRNLGLGKK------SLEQWVTE-----------EAACLCAAFANHSGRPFRPNGL 177

  Fly   197 LHHSLGNIINDLVFGITYKRDDPDWLYLQRLQEEGVKLIGVSG----VVNFLPWLRHLPANVRNI 257
            |..::.|:|..|..|..::.|||.:|.|..|.:||:|  ..||    |:|.:|.|.|:||
Human   178 LDKAVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLK--EESGFLREVLNAVPVLLHIPA----- 235

  Fly   258 RFLLEGKAKTHAIYDRIVEACGQRLKEKQKVFKELQEQKRLQRQLEKEQLRQSKEADPSQEQSEA 322
               |.||.                          |:.||....||::.........||:|
Human   236 ---LAGKV--------------------------LRFQKAFLTQLDELLTEHRMTWDPAQ----- 266

  Fly   323 DEDDEESDEEDTYEPECILEHFLA----VRDTDSQLYCDDQLRHLLADLFGAGVDTSLATLRWFL 383
                         .|..:.|.|||    .:......:.|:.||.::||||.||:.|:..||.|.|
Human   267 -------------PPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGL 318

  Fly   384 LYLAREQRCQRRL-HELLLPLGP--SPTLEELEPLAYLRACISETMRIRSVVPLGIPHGCKENFV 445
            |.:......|||: .|:...:|.  .|.:.:...:.|..|.|.|..|...:||||:.|....:..
Human   319 LLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIE 383

  Fly   446 VGDYFIKGGSMIVCSEWAIHMDPVAFPEPEEFRPERFLTADGAYQAPPQFIPFSSGYRMCPGEEM 510
            |..:.|..|:.::.:..::..|...:.:|..|.||.||.|.|.:..|..|:|||:|.|.|.||.:
Human   384 VQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPL 448

  Fly   511 ARMILTLFTGRILRRFHLELPSG-TEVDMAGESGITLTPTPHML 553
            |||.|.||...:|:.|...:|:| ......|.....::|:|:.|
Human   449 ARMELFLFFTSLLQHFSFSVPTGQPRPSHHGVFAFLVSPSPYEL 492

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
phm	NP_001285414.1	p450	49..555	CDD:278495	149/532 (28%)
CYP2D6	NP_000097.3	p450	58..493	CDD:278495	139/508 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910