Protein Alignment phm and CYP2C18

DIOPT Version :9

• Sequence 1: NP_001285414.1
• Gene: phm / 32857
• FlyBaseID: FBgn0004959
• Length: 574
• Species: Drosophila melanogaster
• Sequence 2: NP_000763.1
• Gene: CYP2C18 / 1562
• HGNCID: 2620
• Length: 490
• Species: Homo sapiens
• Alignment Length: 566
• Identity: 140/566 - (24%)
• Similarity: 234/566 - (41%)
• Gaps: 114/566 - (20%)

  Fly    19 SLSILLVPGALVLVILYLCERQCNDLMGAPPPGPWGLPFLGYLPFLDARAPHKSLQKLAKRYGGI 83
            :::::|....|.|:.|:   ||.:. .|..|.||..||.:|.:..||.:...|||...:|.||.:
Human     4 AVALVLCLSCLFLLSLW---RQSSG-RGRLPSGPTPLPIIGNILQLDVKDMSKSLTNFSKVYGPV 64

  Fly    84 FELKMGRVPTVVLSDAALVRDFF--RRDVMTGRAPLYLTHGIMGGFGIICAQEDIWRHARRETID 146
            |.:..|..|.|||.....|::..  ..:..:||....:...:..|.||:.:....|:..||..:.
Human    65 FTVYFGLKPIVVLHGYEAVKEALIDHGEEFSGRGSFPVAEKVNKGLGILFSNGKRWKEIRRFCLM 129

  Fly   147 WLKALGMTRRPGELRARLERRIARGVDECVRLFDTEAKKSCASEVNPLPALHHSLGNIINDLVFG 211
            .|:..||.:|..|.|          |.|..|....|.:|:.||..:|...|..:..|:|..::|.
Human   130 TLRNFGMGKRSIEDR----------VQEEARCLVEELRKTNASPCDPTFILGCAPCNVICSVIFH 184

  Fly   212 ITYKRDDPDWLYLQRLQEEGVKLIGVSGVVNFLPWLR----------HLPAN----VRNIRFLLE 262
            ..:...|..:|.|.....|.::::.       .||::          :||.:    ..|..::
Human   185 DRFDYKDQRFLNLMEKFNENLRILS-------SPWIQVCNNFPALIDYLPGSHNKIAENFAYI-- 240

  Fly   263 GKAKTHAIYDRIVEACGQRLKEKQKVFKELQEQKRLQRQLEKEQLRQSKEAD------PSQEQSE 321
               |::.:         :|:||.|                  |.|..:...|      ...||
Human   241 ---KSYVL---------ERIKEHQ------------------ESLDMNSARDFIDCFLIKMEQ-- 273

  Fly   322 ADEDDEESDEEDTYEPECILEHFLAVRDTDSQLYCDDQLRHLLADLFGAGVDTSLATLRWFLLYL 386
                     |:...:.|..:|..:|.                :.|:||||.:|:..|||:.||.|
Human   274 ---------EKHNQQSEFTVESLIAT----------------VTDMFGAGTETTSTTLRYGLLLL 313

  Fly   387 AREQRCQRRLH---ELLLPLGPSPTLEELEPLAYLRACISETMRIRSVVPLGIPHGCKENFVVGD 448
            .:......::.   |.::....||.:::...:.|..|.:.|..|...::|..:||....:....:
Human   314 LKYPEVTAKVQEEIECVVGRNRSPCMQDRSHMPYTDAVVHEIQRYIDLLPTNLPHAVTCDVKFKN 378

  Fly   449 YFIKGGSMIVCSEWAIHMDPVAFPEPEEFRPERFLTADGAYQAPPQFIPFSSGYRMCPGEEMARM 513
            |.|..|:.|:.|..::..:...||.||.|.|..||...|.::....|:|||:|.|||.||.:|||
Human   379 YLIPKGTTIITSLTSVLHNDKEFPNPEMFDPGHFLDKSGNFKKSDYFMPFSAGKRMCMGEGLARM 443

  Fly   514 ILTLFTGRILRRFHLELPSGTEVDMAGESGITLTPTPHMLRFTKLP 559
            .|.||...||:.|:|:    ::||   ...|.:||..:  .|.::|
Human   444 ELFLFLTTILQNFNLK----SQVD---PKDIDITPIAN--AFGRVP 480

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
phm	NP_001285414.1	p450	49..555	CDD:278495	131/530 (25%)
CYP2C18	NP_000763.1	p450	30..487	CDD:306555	133/536 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000008
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.910