Protein Alignment phtm and CYP2C8

DIOPT Version :10

• Sequence 1: NP_573319.1
• Gene: phtm / 32857
• FlyBaseID: FBgn0004959
• Length: 574
• Species: Drosophila melanogaster
• Sequence 2: NP_000761.3
• Gene: CYP2C8 / 1558
• HGNCID: 2622
• Length: 490
• Species: Homo sapiens
• Alignment Length: 550
• Identity: 139/550 - (25%)
• Similarity: 220/550 - (40%)
• Gaps: 93/550 - (16%)

  Fly    32 VILYLC----------ERQCNDLMGAPPPGPWGLPFLGYLPFLDARAPHKSLQKLAKRYGGIFEL 86
            |:|.||          .:.|.  ....||||..||.:|.:..:|.:...||....:|.||.:|.:
Human     5 VVLVLCLSFMLLFSLWRQSCR--RRKLPPGPTPLPIIGNMLQIDVKDICKSFTNFSKVYGPVFTV 67

  Fly    87 KMGRVPTVVLSDAALVRDFF--RRDVMTGRAPLYLTHGIMGGFGIICAQEDIWRHARRETIDWLK 149
            ..|..|.||......|::..  ..:..:||....::..|..|.|||.:....|:..||.::..|:
Human    68 YFGMNPIVVFHGYEAVKEALIDNGEEFSGRGNSPISQRITKGLGIISSNGKRWKEIRRFSLTTLR 132

  Fly   150 ALGMTRRPGELRARLERRIARGVDECVRLFDTEAKKSCASEVNPLPALHHSLGNIINDLVFGITY 214
            ..||.:|..|.|          |.|.......|.:|:.||..:|...|..:..|:|..:||...:
Human   133 NFGMGKRSIEDR----------VQEEAHCLVEELRKTKASPCDPTFILGCAPCNVICSVVFQKRF 187

  Fly   215 KRDDPDWLYLQRLQEEGVKLIGVSGVVNFLPWLRHLPANVRNIRFLLEGKAKTHAIYDRIVEACG 279
            ...|.::|.|.:...|..:::.       .||::    ...|...|::....||
Human   188 DYKDQNFLTLMKRFNENFRILN-------SPWIQ----VCNNFPLLIDCFPGTH----------- 230

  Fly   280 QRLKEKQKVFKELQEQKRLQRQLEKEQLRQSKEADPSQEQSEADEDDEESDEEDTYEP----ECI 340
                  .||.|.:    .|.|...:|:::                  |.....|...|    :|.
Human   231 ------NKVLKNV----ALTRSYIREKVK------------------EHQASLDVNNPRDFIDCF 267

  Fly   341 LEHFLAVRDTDSQLYCDDQLRHLLADLFGAGVDTSLATLRWFLLYLAREQRCQRRLHELL---LP 402
            |......:|.....:..:.|...:||||.||.:|:..|||:.||.|.:......::.|.:   :.
Human   268 LIKMEQEKDNQKSEFNIENLVGTVADLFVAGTETTSTTLRYGLLLLLKHPEVTAKVQEEIDHVIG 332

  Fly   403 LGPSPTLEELEPLAYLRACISETMRIRSVVPLGIPHGCKENFVVGDYFIKGGSMIVCSEWAIHMD 467
            ...||.:::...:.|..|.:.|..|...:||.|:||....:....:|.|..|:.|:....::..|
Human   333 RHRSPCMQDRSHMPYTDAVVHEIQRYSDLVPTGVPHAVTTDTKFRNYLIPKGTTIMALLTSVLHD 397

  Fly   468 PVAFPEPEEFRPERFLTADGAYQAPPQFIPFSSGYRMCPGEEMARMILTLFTGRILRRFHLELPS 532
            ...||.|..|.|..||..:|.::....|:|||:|.|:|.||.:|||.|.||...||:.|:|:
Human   398 DKEFPNPNIFDPGHFLDKNGNFKKSDYFMPFSAGKRICAGEGLARMELFLFLTTILQNFNLK--- 459

  Fly   533 GTEVD-------MAGESGITLTPTPHMLRF 555
              .||       .|...||...|..:.:.|
Human   460 --SVDDLKNLNTTAVTKGIVSLPPSYQICF 487

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
phtm	NP_573319.1	CYP306A1-like	81..553	CDD:410745	121/487 (25%)
CYP2C8	NP_000761.3	CYP2C-like	61..485	CDD:410758	122/488 (25%)