Protein Alignment phtm and CYP2B6

DIOPT Version :10

• Sequence 1: NP_573319.1
• Gene: phtm / 32857
• FlyBaseID: FBgn0004959
• Length: 574
• Species: Drosophila melanogaster
• Sequence 2: NP_000758.1
• Gene: CYP2B6 / 1555
• HGNCID: 2615
• Length: 491
• Species: Homo sapiens
• Alignment Length: 556
• Identity: 155/556 - (27%)
• Similarity: 239/556 - (42%)
• Gaps: 84/556 - (15%)

  Fly    20 LSILLVPGALVLVILYLCERQCN--DLMGAPPPGPWGLPFLGYLPFLDARAPHKSLQKLAKRYGG 82
            ||:||....|..::|.|.:|..|  |.:   ||||..||.||.|..:|.|...||..:..::||.
Human     3 LSVLLFLALLTGLLLLLVQRHPNTHDRL---PPGPRPLPLLGNLLQMDRRGLLKSFLRFREKYGD 64

  Fly    83 IFELKMGRVPTVVLSDAALVRDFF--RRDVMTGRAPLYLTHGIMGGFGIICAQEDIWRHARRETI 145
            :|.:.:|..|.|:|.....:|:..  :.:..:||..:.:......|:|:|.|..:.|:..||.::
Human    65 VFTVHLGPRPVVMLCGVEAIREALVDKAEAFSGRGKIAMVDPFFRGYGVIFANGNRWKVLRRFSV 129

  Fly   146 DWLKALGMTRRPGELRARLERRIARGVDECVRLFDTEAKKSCASEVNPLPALHHSLGNIINDLVF 210
            ..::..||.:|..|.|          :.|..:....|.:||..:.::|.........|||..:||
Human   130 TTMRDFGMGKRSVEER----------IQEEAQCLIEELRKSKGALMDPTFLFQSITANIICSIVF 184

  Fly   211 GITYKRDDPDWLYLQRLQEEGVKLIGVSGVVN-----FLPWLRHLPANVRNIRFLLEGKAKTHAI 270
            |..:...|.::|.:..|..:...||  |.|..     |..:|::.|...|
Human   185 GKRFHYQDQEFLKMLNLFYQTFSLI--SSVFGQLFELFSGFLKYFPGAHR--------------- 232

  Fly   271 YDRIVEACGQRLKEKQKVFKELQE-QKRLQRQLEKEQLRQSKEADPSQEQSEADEDDEESDEEDT 334
                            :|:|.||| ...:...:||.:    :..|||..:          |..||
Human   233 ----------------QVYKNLQEINAYIGHSVEKHR----ETLDPSAPK----------DLIDT 267

  Fly   335 YEPECILEHFLAVRDTDSQLYCDDQLRHLLADLFGAGVDTSLATLRW-FLLYLAREQRCQRRLHE 398
            |     |.|....:......:....|......||.||.:|:..|||: |||.|......:|...|
Human   268 Y-----LLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYRE 327

  Fly   399 LLLPLGP--SPTLEELEPLAYLRACISETMRIRSVVPLGIPHGCKENFVVGDYFI-KGGSMIVCS 460
            :...:||  .|.|.:...:.|..|.|.|..|...::|:|:||...::.....|.| |...:.:..
Human   328 IEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLIL 392

  Fly   461 EWAIHMDPVAFPEPEEFRPERFLTADGAYQAPPQFIPFSSGYRMCPGEEMARMILTLFTGRILRR 525
            ..|:| ||..|.:|:.|.|:.||.|:||.:....|||||.|.|:|.||.:||..|.||...||:.
Human   393 STALH-DPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQN 456

  Fly   526 FHLELPSGTE-VDMA-GESGITLTPTPHMLRFTKLP 559
            |.:..|...| :|:. .|.|:...|..:.:||  ||
Human   457 FSMASPVAPEDIDLTPQECGVGKIPPTYQIRF--LP 490

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
phtm	NP_573319.1	CYP306A1-like	81..553	CDD:410745	127/485 (26%)
CYP2B6	NP_000758.1	CYP2B	62..486	CDD:410765	128/486 (26%)