DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment phm and CYP2A7

DIOPT Version :9

Sequence 1:	NP_001285414.1	Gene:	phm / 32857	FlyBaseID:	FBgn0004959	Length:	574	Species:	Drosophila melanogaster
Sequence 2:	NP_000755.2	Gene:	CYP2A7 / 1549	HGNCID:	2611	Length:	494	Species:	Homo sapiens

Alignment Length:	579	Identity:	135/579 - (23%)
Similarity:	237/579 - (40%)	Gaps:	129/579 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 LVPGALVLVILYLC-----------ERQCNDLMGAPPPGPWGLPFLGYLPFLDARAPH--KSLQK 75
            ::...|:||.|..|           :|:..   |..||||..|||:|  .:|.....|  .|:.|
Human     1 MLASGLLLVALLACLTVMVLMSVWQQRKSR---GKLPPGPTPLPFIG--NYLQLNTEHICDSIMK 60

  Fly    76 LAKRYGGIFELKMGRVPTVVLSDAALVRDFFRRDVMTGRAPLYLTHGIMGGFGIICAQEDIWRHA 140
            .::.||.:|.:.:|....|||.....||:                       .::...|:.....
Human    61 FSECYGPVFTIHLGPRRVVVLCGHDAVRE-----------------------ALVDQAEEFSGRG 102

  Fly   141 RRETIDWL-KALGMTRRPGELRARLERRIA-----------RGVDECVRL---FDTEAKKSC-AS 189
            .:.|.||: |..|:....|| ||:...|.|           ||::|.::.   |..||.:|. .:
Human   103 EQATFDWVFKGYGVAFSNGE-RAKQLLRFAIATLRDFGVGKRGIEERIQEESGFLIEAIRSTHGA 166

  Fly   190 EVNPLPALHHSLGNIINDLVFGITYKRDDPDWLYLQRLQEEGVKLIGVSGVVN---------FLP 245
            .::|...|..::.|:|:.:|||..:..:|.::|.|..:      ::|:....:         |..
Human   167 NIDPTFFLSRTVSNVISSIVFGDRFDYEDKEFLSLLSM------MLGIFQFTSTSTGQLYEMFSS 225

  Fly   246 WLRHLPANVRNIRFLLEGKAKTHAIYDRIVEACGQRLKEKQKVFKELQEQKRLQRQLEKEQLRQS 310
            .::|||.                               .:|:.||.||   .|:..:.|:.....
Human   226 VMKHLPG-------------------------------PQQQAFKLLQ---GLEDFIAKKVEHNQ 256

  Fly   311 KEADPSQEQSEADEDDEESDEEDTYEPECILEHFLAVRDTDSQLYCDDQLRHLLADLFGAGVDTS 375
            :..||:..|...|.......||:              ::.:::.|..:.:...| :||.||.:|.
Human   257 RTLDPNSPQDFIDSFLIHMQEEE--------------KNPNTEFYLKNLMMSTL-NLFIAGTETV 306

  Fly   376 LATLRWFLLYLAREQRCQRRLHE---LLLPLGPSPTLEELEPLAYLRACISETMRIRSVVPLGIP 437
            ..|||:..|.|.:....:.::||   .::.....|..|:...:.|:.|.|.|..|...|:|:.:.
Human   307 STTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRTKMPYMEAVIHEIQRFGDVIPMSLA 371

  Fly   438 HGCKENFVVGDYFIKGGSMIVCSEWAIHMDPVAFPEPEEFRPERFLTADGAYQAPPQFIPFSSGY 502
            ...|::....|:|:..|:.:.....::..||..|..|::|.|:.||...|.::....|:|||.|.
Human   372 RRVKKDTKFRDFFLPKGTEVFPMLGSVLRDPSFFSNPQDFNPQHFLDDKGQFKKSDAFVPFSIGK 436

  Fly   503 RMCPGEEMARMILTLFTGRILRRFHLE-LPSGTEVDMAGESGITLT-PTPHMLRFTKLP 559
            |.|.||.:|||.|.||...:::.|.|: ..|..::|::.:..:..| |..:.:.|  ||
Human   437 RNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHVVFATIPRNYTMSF--LP 493

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
phm	NP_001285414.1	p450	49..555	CDD:278495	125/537 (23%)
CYP2A7	NP_000755.2	p450	34..491	CDD:278495	125/537 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000008
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	3.000