Protein Alignment phm and CYP2A6

DIOPT Version :9

• Sequence 1: NP_001285414.1
• Gene: phm / 32857
• FlyBaseID: FBgn0004959
• Length: 574
• Species: Drosophila melanogaster
• Sequence 2: NP_000753.3
• Gene: CYP2A6 / 1548
• HGNCID: 2610
• Length: 494
• Species: Homo sapiens
• Alignment Length: 566
• Identity: 131/566 - (23%)
• Similarity: 243/566 - (42%)
• Gaps: 103/566 - (18%)

  Fly    24 LVPGALVLVILYLC-----------ERQCNDLMGAPPPGPWGLPFLGYLPFLDARAPHKSLQKLA 77
            ::...::||.|.:|           :|:..   |..||||..|||:|....|:....:.||.|::
Human     1 MLASGMLLVALLVCLTVMVLMSVWQQRKSK---GKLPPGPTPLPFIGNYLQLNTEQMYNSLMKIS 62

  Fly    78 KRYGGIFELKMGRVPTVVLSDAALVRDFF--RRDVMTGRAPLYLTHGIMGGFGIICAQEDIWRHA 140
            :|||.:|.:.:|....|||.....||:..  :.:..:||........:..|:|::.:..:..:..
Human    63 ERYGPVFTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVFKGYGVVFSNGERAKQL 127

  Fly   141 RRETIDWLKALGMTRRPGELRARLERRIARGVDECVRLFDTEAKKSCASEVNPLPALHHSLGNII 205
            ||.:|..|:..|:.:|      .:|.||.   :|...|.|. .:.:..:.::|...|..::.|:|
Human   128 RRFSIATLRDFGVGKR------GIEERIQ---EEAGFLIDA-LRGTGGANIDPTFFLSRTVSNVI 182

  Fly   206 NDLVFGITYKRDDPDWLYLQRLQEEGVKLIGVSGVVN---------FLPWLRHLPANVRNIRFLL 261
            :.:|||..:...|.::|.|.|:      ::|:....:         |...::|||.
Human   183 SSIVFGDRFDYKDKEFLSLLRM------MLGIFQFTSTSTGQLYEMFSSVMKHLPG--------- 232

  Fly   262 EGKAKTHAIYDRIVEACGQRLKEKQKVFKELQEQKRLQRQLEKEQLRQSKEADPSQEQSEADEDD 326
                                  .:|:.|:.||   .|:..:.|:.....:..||:..:...|...
Human   233 ----------------------PQQQAFQLLQ---GLEDFIAKKVEHNQRTLDPNSPRDFIDSFL 272

  Fly   327 EESDEEDTYEPECILEHFLAVRDTDSQLYCDDQLRHLL---ADLFGAGVDTSLATLRWFLLYLAR 388
            ....||:              ::.:::.|    |::|:   .:||..|.:|...|||:..|.|.:
Human   273 IRMQEEE--------------KNPNTEFY----LKNLVMTTLNLFIGGTETVSTTLRYGFLLLMK 319

  Fly   389 EQRCQRRLHE---LLLPLGPSPTLEELEPLAYLRACISETMRIRSVVPLGIPHGCKENFVVGDYF 450
            ....:.::||   .::.....|..|:...:.|:.|.|.|..|...|:|:.:....|::....|:|
Human   320 HPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYMEAVIHEIQRFGDVIPMSLARRVKKDTKFRDFF 384

  Fly   451 IKGGSMIVCSEWAIHMDPVAFPEPEEFRPERFLTADGAYQAPPQFIPFSSGYRMCPGEEMARMIL 515
            :..|:.:.....::..||..|..|::|.|:.||...|.::....|:|||.|.|.|.||.:|||.|
Human   385 LPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHFLNEKGQFKKSDAFVPFSIGKRNCFGEGLARMEL 449

  Fly   516 TLFTGRILRRFHLE-LPSGTEVDMAGES-GITLTPTPHMLRFTKLP 559
            .||...:::.|.|: ..|..::|::.:. |....|..:.:.|  ||
Human   450 FLFFTTVMQNFRLKSSQSPKDIDVSPKHVGFATIPRNYTMSF--LP 493

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
phm	NP_001285414.1	p450	49..555	CDD:278495	122/524 (23%)
CYP2A6	NP_000753.3	p450	34..491	CDD:365848	122/524 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000008
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.910