Protein Alignment phtm and CYP1B1

DIOPT Version :10

• Sequence 1: NP_573319.1
• Gene: phtm / 32857
• FlyBaseID: FBgn0004959
• Length: 574
• Species: Drosophila melanogaster
• Sequence 2: NP_000095.2
• Gene: CYP1B1 / 1545
• HGNCID: 2597
• Length: 543
• Species: Homo sapiens
• Alignment Length: 594
• Identity: 153/594 - (25%)
• Similarity: 245/594 - (41%)
• Gaps: 115/594 - (19%)

  Fly    16 SVQSLSILLVPGALVLV-----ILYLCERQCNDLMGAPPPGPWGLPFLGYLPFLDARAPHKSLQK 75
            |:|..::||:...|..|     :|    ||....:.:.||||:..|.:|....: .:|.|.|..:
Human    17 SIQQTTLLLLLSVLATVHVGQRLL----RQRRRQLRSAPPGPFAWPLIGNAAAV-GQAAHLSFAR 76

  Fly    76 LAKRYGGIFELKMGRVPTVVLSDAALVRDFFRRDVMTGRA----PLYLTHGIMGG-----FGIIC 131
            ||:|||.:|::::|..|.|||:....:....   |..|.|    |.:.:..::.|     ||
Human    77 LARRYGDVFQIRLGSCPIVVLNGERAIHQAL---VQQGSAFADRPAFASFRVVSGGRSMAFG--- 135

  Fly   132 AQEDIWRHARRETIDWLKALGMTRRPGELRAR--LERRIARGVDECVRLFDTEAKKSCASEVNPL 194
            ...:.|:..||.....::.. .||:|   |:|  ||..:.....|.|.|....:......:..||
Human   136 HYSEHWKVQRRAAHSMMRNF-FTRQP---RSRQVLEGHVLSEARELVALLVRGSADGAFLDPRPL 196

  Fly   195 PALHHSLGNIINDLVFGITYKRDDPDWLYLQRLQEEGVKLIGVSGVVNFLPWLRHLPANVRNI-- 257
            ..:  ::.|:::.:.||..|..|||::..|....||..:.:|...:|:.:|||::.|..||.:
Human   197 TVV--AVANVMSAVCFGCRYSHDDPEFRELLSHNEEFGRTVGAGSLVDVMPWLQYFPNPVRTVFR 259

  Fly   258 RFLLEGKAKTHAIYDRIVEACGQRLKEKQKVFKELQEQKRLQRQLEKEQLRQSKEADP------- 315
            .|....:..::.|.|:.:..|                          |.||..  |.|
Human   260 EFEQLNRNFSNFILDKFLRHC--------------------------ESLRPG--AAPRDMMDAF 296

  Fly   316 --SQEQSEADEDDEESDEEDTYEPECILEHFLAVRDTDSQLYCDDQLRHLLADLFGAGVDTSLAT 378
              |.|:..|.:........|       ||:..|.                :.|:|||..||....
Human   297 ILSAEKKAAGDSHGGGARLD-------LENVPAT----------------ITDIFGASQDTLSTA 338

  Fly   379 LRWFLLYLAR----EQRCQRRLHELL----LP-LGPSPTLEELEPLAYLRACISETMRIRSVVPL 434
            |:|.||...|    :.|.|..|.:::    || :|..|.      |.|:.|.:.|.||..|.||:
Human   339 LQWLLLLFTRYPDVQTRVQAELDQVVGRDRLPCMGDQPN------LPYVLAFLYEAMRFSSFVPV 397

  Fly   435 GIPHGCKENFVVGDYFIKGGSMIVCSEWAIHMDPVAFPEPEEFRPERFLTADGAY--QAPPQFIP 497
            .|||....|..|..|.|...:::..::|:::.||:.:|.||.|.|.|||..||..  ....:.:.
Human   398 TIPHATTANTSVLGYHIPKDTVVFVNQWSVNHDPLKWPNPENFDPARFLDKDGLINKDLTSRVMI 462

  Fly   498 FSSGYRMCPGEEMARMILTLFTGRILRRFHLELPSGTEVDMAGESGITLTPTPHMLRFTKLPAVE 562
            ||.|.|.|.|||:::|.|.||...:..:............|....|:|:.|....:..|...::|
Human   463 FSVGKRRCIGEELSKMQLFLFISILAHQCDFRANPNEPAKMNFSYGLTIKPKSFKVNVTLRESME 527

  Fly   563 MRHAPDGAV 571
            :.   |.||
Human   528 LL---DSAV 533

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
phtm	NP_573319.1	CYP306A1-like	81..553	CDD:410745	126/504 (25%)
CYP1B1	NP_000095.2	CYP1B1-like	81..518	CDD:410768	127/505 (25%)