Protein Alignment phtm and CYP1A1

DIOPT Version :10

• Sequence 1: NP_573319.1
• Gene: phtm / 32857
• FlyBaseID: FBgn0004959
• Length: 574
• Species: Drosophila melanogaster
• Sequence 2: NP_000490.1
• Gene: CYP1A1 / 1543
• HGNCID: 2595
• Length: 512
• Species: Homo sapiens
• Alignment Length: 509
• Identity: 143/509 - (28%)
• Similarity: 229/509 - (44%)
• Gaps: 61/509 - (11%)

  Fly    49 PPGPWGLPFLGYLPFLDARAPHKSLQKLAKRYGGIFELKMGRVPTVVLSDAALVRDFFRR--DVM 111
            ||||||.|.:|::..| .:.||.:|.:::::||.:.::::|..|.||||....:|....|  |..
Human    40 PPGPWGWPLIGHMLTL-GKNPHLALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQALVRQGDDF 103

  Fly   112 TGRAPLYLTHGIMGGFGIICAQED--IWRHARRETIDWLKALGMTRRP-GELRARLERRIARGVD 173
            .||..||....|..|..:..:.:.  :|...||...:.||:..:...| ......||..:::..:
Human   104 KGRPDLYTFTLISNGQSMSFSPDSGPVWAARRRLAQNGLKSFSIASDPASSTSCYLEEHVSKEAE 168

  Fly   174 ECVRLFDTEAKKSCASEVNPLPALHHSLGNIINDLVFGITYKRDDPDWLYLQRLQEEGVKLIGVS 238
              |.:...:...:.....||...:..|:.|:|..:.||..|..:..:.|.|..|.....:::|..
Human   169 --VLISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGRRYDHNHQELLSLVNLNNNFGEVVGSG 231

  Fly   239 GVVNFLPWLRHLP-ANVRNIRFLLEGKAKTHAIYDRIVEACGQRLKEKQKVFKELQEQKRLQRQL 302
            ...:|:|.||:|| .::...:.|.|   |.::...::|       ||..|.|
Human   232 NPADFIPILRYLPNPSLNAFKDLNE---KFYSFMQKMV-------KEHYKTF------------- 273

  Fly   303 EKEQLRQSKEADPSQEQSEADEDDEESDEEDTYEPECILEHFLAVRDTDSQLYCDDQLRHLLADL 367
            ||..:|..  .|...|..:..:.||.::.:                      ..|:::.:::.||
Human   274 EKGHIRDI--TDSLIEHCQEKQLDENANVQ----------------------LSDEKIINIVLDL 314

  Fly   368 FGAGVDTSLATLRWFLLYLAREQRCQRRLHELL-LPLGPS--PTLEELEPLAYLRACISETMRIR 429
            ||||.||....:.|.|:||....|.||::.|.| ..:|.|  |.|.:...|.|:.|.|.||.|..
Human   315 FGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHS 379

  Fly   430 SVVPLGIPHGCKENFVVGDYFIKGGSMIVCSEWAIHMDPVAFPEPEEFRPERFLTADGAYQ--AP 492
            |.||..|||....:..:..::|..|..:..::|.|:.|...:..|.||.||||||.|||..  ..
Human   380 SFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLS 444

  Fly   493 PQFIPFSSGYRMCPGEEMARMILTLFTGRILRRFHLELPSGTEVDMAGESGITL 546
            .:.|.|..|.|.|.||.:||..:.||...:|:|....:|.|.:|||....|:|:
Human   445 EKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEFSVPLGVKVDMTPIYGLTM 498

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
phtm	NP_573319.1	CYP306A1-like	81..553	CDD:410745	130/477 (27%)
CYP1A1	NP_000490.1	Mitochondrial targeting signal. /evidence=ECO:0000250|UniProtKB:P00185	29..40		143/509 (28%)
		CYP1A	70..505	CDD:410769	131/478 (27%)