DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment phm and Cyp2j5

DIOPT Version :9

Sequence 1:	NP_001285414.1	Gene:	phm / 32857	FlyBaseID:	FBgn0004959	Length:	574	Species:	Drosophila melanogaster
Sequence 2:	NP_034137.1	Gene:	Cyp2j5 / 13109	MGIID:	1270149	Length:	501	Species:	Mus musculus

Alignment Length:	524	Identity:	132/524 - (25%)
Similarity:	225/524 - (42%)	Gaps:	77/524 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 PPGPWGLPFLGYLPFLDARAPHKSLQKLAKRYGGIFELKMGRVPTVVLSDAALVRDFFRR--DVM 111
            |||||.|||:|....:|.:..|..||:..|:||.:|.|::|:.|.||:|...|:::.|..  ...
Mouse    44 PPGPWRLPFVGNFFQIDTKQTHLVLQQFVKKYGNVFSLELGQSPVVVVSGLPLIKEMFTHLDQNF 108

  Fly   112 TGRAPLYLTHGIMGGFGIICAQEDIWRHARRETIDWLKALGMTRRPGELRARLERRIARGVDECV 176
            ..|....:...|.|..|::.:....|:..||..:..|:..|:.::      .||.||.......|
Mouse   109 VNRFMTPVRERITGKNGLVVSNGQTWKEQRRLALMALRNFGLGKK------SLEERIQEETHHLV 167

  Fly   177 RLFDTEAKKSCASEVNPLPALHHSLGNIINDLVFGITYKRDDPDWLYLQRLQEEGVKLIGVSG-- 239
            .....|.    ....||...|.:::.|||..:.||..:..:|..:..|.:|.:|.:.|:|.|.
Mouse   168 EAIREEG----GQPFNPHLKLINAVSNIICSVTFGERFDYEDCQFQELLQLLDETMHLMGSSAGQ 228

  Fly   240 VVNFLPW-LRHLPANVRNIRFLLEGKAKTHAIYDRIVEACGQRLKEKQKVFKELQEQKRLQRQLE 303
            :.|..|. :::||.                               ..||:|:...:.|.....:.
Mouse   229 LYNGFPCIMKYLPG-------------------------------PHQKIFRNWGKLKLFVSHIV 262

  Fly   304 KEQLRQSKEADPSQEQSEADEDDEESDEEDTYEPECILEHFLAVRDTD---SQLYCDDQLRHLLA 365
            |   :..|:.:|.                   ||...::.||.....|   :..:.::.|.....
Mouse   263 K---KHEKDWNPD-------------------EPRDFIDAFLIEMQKDPDRTTSFNEENLISTTL 305

  Fly   366 DLFGAGVDTSLATLRWFLLYLAREQRCQRRLH-ELLLPLG--PSPTLEELEPLAYLRACISETMR 427
            |||..|.:|:.:||||.|||::.....|..:. |:...:|  ...:|.:.|.:.|..|.|.|..|
Mouse   306 DLFLGGTETTSSTLRWALLYMSSYPEIQENVQAEIDRVIGHKRQVSLSDRESMPYTNAVIHEVQR 370

  Fly   428 IRSVVPLGIPHGCKENFVVGDYFIKGGSMIVCSEWAIHMDPVAFPEPEEFRPERFLTADGAYQAP 492
            :.::|||........:.....:.:..|:||:.:..|:|.||..:..||.|.||.|| .:|.::..
Mouse   371 MGNIVPLNSSREVTVDTKFNGFHLPKGTMILTNLTALHRDPKEWATPEVFNPEHFL-ENGQFKKR 434

  Fly   493 PQFIPFSSGYRMCPGEEMARMILTLFTGRILRRFHLELPSGTEVDMAGESGITLTPTPHMLRFTK 557
            ..|:|||.|.|.|.||::|:..|.:|...::::|..:.|...::.:....|:.|:|..:  |...
Mouse   435 ESFLPFSMGKRACLGEQLAKSELFIFFSALMQKFTFKPPINEKLSLKFRMGLILSPASY--RICA 497

  Fly   558 LPAV 561
            :|.|
Mouse   498 IPRV 501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
phm	NP_001285414.1	p450	49..555	CDD:278495	129/516 (25%)
Cyp2j5	NP_034137.1	p450	44..496	CDD:278495	130/517 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000008
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.910