Protein Alignment phtm and Cyp2e1

DIOPT Version :10

• Sequence 1: NP_573319.1
• Gene: phtm / 32857
• FlyBaseID: FBgn0004959
• Length: 574
• Species: Drosophila melanogaster
• Sequence 2: NP_067257.1
• Gene: Cyp2e1 / 13106
• MGIID: 88607
• Length: 493
• Species: Mus musculus
• Alignment Length: 529
• Identity: 141/529 - (26%)
• Similarity: 227/529 - (42%)
• Gaps: 97/529 - (18%)

  Fly    49 PPGPWGLPFLGYLPFLDARAPHKSLQKLAKRYGGIFELKMGRVPTVVLSDAALVRDFF--RRDVM 111
            ||||:.:||.|.:..||.:...|||.|||||:|.:|.|.:|:...|||.....|::..  .::..
Mouse    33 PPGPFPIPFFGNIFQLDLKDIPKSLTKLAKRFGPVFTLHLGQRRIVVLHGYKAVKEVLLNHKNEF 97

  Fly   112 TGRA--PLYLTHGIMGGFGIICAQEDIWRHARRETIDWLKALGMTRRPGELRARLERRIARGVDE 174
            :||.  |::..:   ...|||......|:..||.::..|:..||.::..|  ||::|.
Mouse    98 SGRGDIPVFQEY---KNKGIIFNNGPTWKDVRRFSLSILRDWGMGKQGNE--ARIQRE------- 150

  Fly   175 CVRLFDTEAKKSCASEVNPLPALHHSLGNIINDLVFGITYKRDDPDWLYLQRLQEEGVKLIG--- 236
             ......|.||:.....:|...:..:..|:|.|::|...:..||...|.|..|..|...|:.
Mouse   151 -AHFLVEELKKTKGQPFDPTFLIGCAPCNVIADILFNKRFDYDDKKCLELMSLFNENFYLLSTPW 214

  Fly   237 VSGVVNFLPWLRHLPA-------NVRNIRFLLEGKAKTHAIYDRIVEACGQRLKEKQKVFKELQE 294
            :.....|..:|::||.       ||..||....||||.|.
Mouse   215 IQAYNYFSDYLQYLPGSHRKVMKNVSEIRQYTLGKAKEHL------------------------- 254

  Fly   295 QKRLQRQLEKEQLRQSKEADPSQEQSEADEDDEESDEEDTYEPECILEHFLAVRDTDSQLYCDDQ 359
                            |..|.:..:...|               |:|......:.:...:|..:.
Mouse   255 ----------------KSLDINCPRDVTD---------------CLLIEMEKEKHSQEPMYTMEN 288

  Fly   360 LRHLLADLFGAGVDTSLATLRWFLLYLAREQRCQRRLHELL-LPLGPS--PTLEELEPLAYLRAC 421
            :...|||||.||.:|:..|||:.||.|.:....:.:|||.: ..:|||  |.:.:...:.|:.|.
Mouse   289 ISVTLADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRAPAVRDRMNMPYMDAV 353

  Fly   422 ISETMRIRSVVPLGIPHGCKENFVVGDYFIKGGSMIVCSEWAIHMDPVAFPEPEEFRPERFLTAD 486
            :.|..|..::||..:||....:.|...|.|..|::::.:..::..|...||:||.|:||.||..:
Mouse   354 VHEIQRFINLVPSNLPHEATRDTVFRGYVIPKGTVVIPTLDSLLFDNYEFPDPETFKPEHFLNEN 418

  Fly   487 GAYQAPPQFIPFSSGYRMCPGEEMARMILTLFTGRILRRFHLE-LPSGTEVDMAGESGITLTPTP 550
            |.::....|..||:|.|:|.||.:|||.|.|....||:.|:|: |....::|:          :|
Mouse   419 GKFKYSDYFKAFSAGKRVCVGEGLARMELFLLLSAILQHFNLKSLVDPKDIDL----------SP 473

  Fly   551 HMLRFTKLP 559
            ..:.|..:|
Mouse   474 VTIGFGSIP 482

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
phtm	NP_573319.1	CYP306A1-like	81..553	CDD:410745	122/489 (25%)
Cyp2e1	NP_067257.1	CYP2C-like	64..487	CDD:410758	124/498 (25%)