Protein Alignment phtm and Cyp2d10

DIOPT Version :10

• Sequence 1: NP_573319.1
• Gene: phtm / 32857
• FlyBaseID: FBgn0004959
• Length: 574
• Species: Drosophila melanogaster
• Sequence 2: NP_034135.2
• Gene: Cyp2d10 / 13101
• MGIID: 88602
• Length: 504
• Species: Mus musculus
• Alignment Length: 536
• Identity: 143/536 - (26%)
• Similarity: 232/536 - (43%)
• Gaps: 93/536 - (17%)

  Fly    19 SLSILLVPGALVLVILYLCERQCNDLMGAPPPGPWGLPFLGYLPFLDARAPHKSLQKLAKRYGGI 83
            |::|..|...|::.:::..:|..:..    ||||...|.||.|..:|......||.||..|||.:
Mouse    11 SVAIFTVIFILLVDLMHRHQRWTSRY----PPGPVPWPVLGNLLQVDLDNMPYSLYKLQNRYGDV 71

  Fly    84 FELKMGRVPTVVLSDAALVRDFFRRDVMT--------GRAPLYLTHGIM-GGFGIICA-QEDIWR 138
            |.|:||..|.||::....:::.    ::|        .:.|::...|:. |..|::.| ....||
Mouse    72 FSLQMGWKPMVVINGLKAMKEV----LLTCGEDTADRPQVPIFEYLGVKPGSQGVVLAPYGPEWR 132

  Fly   139 HARRETIDWLKALGMTRRPGELRARLERRIARGVDECVRLFDTEAKKSCASEVNPLPALHHSLGN 203
            ..||.::..|:..|:.::      .||..:.:........|..:|    ...:||...|::::.|
Mouse   133 EQRRFSVSTLRNFGLGKK------SLEDWVTKEARHLCDAFTAQA----GQPINPNTMLNNAVCN 187

  Fly   204 IINDLVFGITYKRDDPDWLYLQRLQEEGVKLIGVSG----VVNFLPWLRHLPANVRNIRFLLEGK 264
            :|..|:|...::.:||..:.:|::.|:  .|..:||    |:|..|.|..:|.        |.|
Mouse   188 VIASLIFARRFEYEDPYLIRMQKVLED--SLTEISGLIPEVLNMFPILLRIPG--------LPG- 241

  Fly   265 AKTHAIYDRIVEACGQRLKEKQKVFKELQEQKRLQRQLEKEQLRQSKEADPSQEQSEADEDDEES 329
                                  |||   |.||.|...:|..........||.|
Mouse   242 ----------------------KVF---QGQKSLLAIVENLLTENRNTWDPDQ------------ 269

  Fly   330 DEEDTYEPECILEHFLA----VRDTDSQLYCDDQLRHLLADLFGAGVDTSLATLRWFLLYLAREQ 390
                  .|..:.:.|||    |:......:.|:.||.::.|||.||:.|:..||.|.||.:....
Mouse   270 ------PPRNLTDAFLAEIEKVKGNAESSFNDENLRMVVLDLFTAGMVTTSTTLSWALLLMILHP 328

  Fly   391 RCQRRL-HELLLPLGP--SPTLEELEPLAYLRACISETMRIRSVVPLGIPHGCKENFVVGDYFIK 452
            ..|||: .|:...:|.  .|.:.:...:.|..|.|.|..|...:.||.:|.....:..|.|:.|.
Mouse   329 DVQRRVQQEIDAVIGQVRHPEMADQARMPYTNAVIHEVQRFGDIAPLNLPRITSRDIEVQDFLIP 393

  Fly   453 GGSMIVCSEWAIHMDPVAFPEPEEFRPERFLTADGAYQAPPQFIPFSSGYRMCPGEEMARMILTL 517
            .||:::.:..::..|...:.:|..|.||.||.|.|.:..|..|:|||:|.|.|.||.:|||.|.|
Mouse   394 KGSILIPNMSSVLKDETVWEKPLRFHPEHFLDAQGHFVKPEAFMPFSAGRRSCLGEPLARMELFL 458

  Fly   518 FTGRILRRFHLELPSG 533
            |...:|:.|...:|:|
Mouse   459 FFTCLLQHFSFSVPNG 474

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
phtm	NP_573319.1	CYP306A1-like	81..553	CDD:410745	123/474 (26%)
Cyp2d10	NP_034135.2	CYP2D	68..495	CDD:410756	124/475 (26%)