DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment phm and Cyp2b9

DIOPT Version :9

Sequence 1:	NP_001285414.1	Gene:	phm / 32857	FlyBaseID:	FBgn0004959	Length:	574	Species:	Drosophila melanogaster
Sequence 2:	XP_011248733.1	Gene:	Cyp2b9 / 13094	MGIID:	88600	Length:	517	Species:	Mus musculus

Alignment Length:	577	Identity:	142/577 - (24%)
Similarity:	237/577 - (41%)	Gaps:	138/577 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 GWMPSVQSLSILLVPGALVLVILYLCERQCNDLMG---------APPPGPWGLPFLGYLPFLDAR 67
            ||:       ||::.|.|..|  |....|..|:.|         ||               ||
Mouse    43 GWI-------ILMIAGLLRKV--YGAVEQTMDVRGKQNALVIQHAP---------------LD-- 81

  Fly    68 APHKSLQKLAKRYGGIFELKMGRVPTVVLSDAALVRDFF--RRDVMTGRAPLYLTHGIMGGFGII 130
                  |:|.:::|.:|.:.:|..|.|||.....:|:..  ..:..:||..:.....:|..:||.
Mouse    82 ------QRLQEKHGDVFTVHLGPRPVVVLCGTQTIREALVDHAEAFSGRGTIAAAQLVMQDYGIF 140

  Fly   131 CAQEDIWRHARRETIDWLKALGMTRRPGELRARLERRIARGVDECVRLFDTEAKKSCASEVNPLP 195
            .|....|:..||.::..:|..||.:|..|.|.:.|.       :|:   ..|.||.....::|..
Mouse   141 FASGQRWKTLRRFSLATMKEFGMGKRSVEERIKEEA-------QCL---VEELKKYQGVPLDPTF 195

  Fly   196 ALHHSLGNIINDLVFGITYKRDDPDWLYLQRLQEEGVKLI-GVSGVV--NFLPWLRHLPANVRNI 257
            .......|||..:|||..:...|..:|:|..|..:...|: ..||.:  .|..:|::.|...|.|
Mouse   196 LFQCITANIICSIVFGERFDYTDDQFLHLLNLMYKIFSLLSSFSGQMFELFSGFLKYFPGVHRQI 260

  Fly   258 RFLLEGKAKTHAIYDRIVEACGQRLKEKQKVFKELQEQKRLQRQLEKEQLRQSKEADPSQEQSEA 322
                                    :|::|::.      ..:...:||.:    ...|||..:...
Mouse   261 ------------------------VKKQQELL------DYIAHSVEKHK----ATLDPSAPRDYI 291

  Fly   323 DE-----DDEESDEEDTYEPECILEHFLAVRDTDSQLYCDDQLRHLLADLFGAGVDTSLATLRWF 382
            |.     :.|:|:....:..:.::...|:                    ||.||.:|:.|||.:.
Mouse   292 DTYLLRMEKEKSNHNTEFHHQNLMMSVLS--------------------LFFAGTETTSATLHYG 336

  Fly   383 LLYLAR----EQRCQRRL------HELLLPLGPSPTLEELEPLAYLRACISETMRIRSVVPLGIP 437
            :|.:.:    .::.|:.:      |.|       |||::...:.|..|.|.|..|...:||:|:|
Mouse   337 VLLMLKYPHVTEKVQKEIDQVIGSHRL-------PTLDDRTKMPYTDAVIHEIQRFSDLVPIGLP 394

  Fly   438 HGCKENFVVGDYFIKGGSMI--VCSEWAIHMDPVAFPEPEEFRPERFLTADGAYQAPPQFIPFSS 500
            |...::.:...|.:...:.:  |.|. |:| ||..|.:|::|.||.||.|:||.:....|:|||:
Mouse   395 HKVIKDTLFRGYLLPKNTEVYPVLSS-ALH-DPQYFEQPDKFNPEHFLDANGALKKCEAFLPFST 457

  Fly   501 GYRMCPGEEMARMILTLFTGRILRRFHLELP-SGTEVDMA-GESGITLTPTPHMLRF 555
            |.|:|.||.:||..|.:|...||:.|.:..| :..::|:. .||||...|..|.:.|
Mouse   458 GKRICLGESIARNELFIFFTTILQNFSVASPVAPKDIDLTPKESGIGKIPPAHQIYF 514

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
phm	NP_001285414.1	p450	49..555	CDD:278495	128/529 (24%)
Cyp2b9	XP_011248733.1	p450	82..512	CDD:365848	126/502 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000008
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.000