Protein Alignment phtm and Cyp2b19

DIOPT Version :10

• Sequence 1: NP_573319.1
• Gene: phtm / 32857
• FlyBaseID: FBgn0004959
• Length: 574
• Species: Drosophila melanogaster
• Sequence 2: NP_031840.1
• Gene: Cyp2b19 / 13090
• MGIID: 107303
• Length: 492
• Species: Mus musculus
• Alignment Length: 550
• Identity: 151/550 - (27%)
• Similarity: 240/550 - (43%)
• Gaps: 79/550 - (14%)

  Fly    21 SILLVPGALVLVILYLCERQCNDLMGAPPPGPWGLPFLGYLPFLDARAPHKSLQKLAKRYGGIFE 85
            |:||:.......:::|..:......|..||||..|||||.|..:|.|....|..:|.::||.:|.
Mouse     4 SVLLLLALTTGFLIFLVSQSQPKTHGHFPPGPRPLPFLGNLLQMDRRGLLSSFIQLQEKYGDVFT 68

  Fly    86 LKMGRVPTVVLSDAALVRDFF--RRDVMTGRAPLYLTHGIMGGFGIICAQEDIWRHARRETIDWL 148
            :.:|..|.|:|.....:|:..  :.:..:||..:.:...|:.|:|:|.:..:.|:..||.::..:
Mouse    69 VHLGPRPVVMLCGTDTIREALVNQAEAFSGRGTVAVLDPIVQGYGVIFSSGERWKTLRRFSLATM 133

  Fly   149 KALGMTRRPGELRARLERRIARGVDECVRLFDTEAKKSCASEVNPLPALHHSLGNIINDLVFGIT 213
            :..||.:|..|.|.:.|.       :|:   ..|.||...:.:||.......:.|||..:|||..
Mouse   134 RDFGMGKRSVEERIKEEA-------QCL---VEELKKYKGAPLNPTFYFQCIVANIICSIVFGER 188

  Fly   214 YKRDDPDWLYLQRLQEEGVKLI-GVSGVV--NFLPWLRHLPANVRNIRFLLEGKAKTHAIYDRIV 275
            :...|..:|:|..|..:...|: .:|..|  .|...|::.|...|.|.
Mouse   189 FDYKDHQFLHLLNLIYQTFSLMSSLSSQVFELFSAILKYFPGAHRQIS----------------- 236

  Fly   276 EACGQRLKEKQKVFKELQE-QKRLQRQLEKEQLRQSKEADPSQEQSEADEDDEESDEEDTYEPEC 339
                          |.||| ...:...:||.:    ...|||..:          |..|||
Mouse   237 --------------KNLQEILDYIGHSVEKHR----ATLDPSAPR----------DFIDTY---- 269

  Fly   340 ILEHFLAVRDTDSQLYCDDQLRHL---LADLFGAGVDTSLATLRW-FLLYLAREQRCQRRLHELL 400
                .|.:....|..:.:...::|   :..||.||.:|:..|||: ||:.|......::...|:.
Mouse   270 ----LLRMEKEKSNHHTEFHHQNLVISVLSLFFAGTETTSTTLRYSFLIMLKYPHVAEKVQKEID 330

  Fly   401 LPLGPS--PTLEELEPLAYLRACISETMRIRSVVPLGIPHGCKENFVVGDYFI-KGGSMIVCSEW 462
            ..:|..  |||::...:.|..|.|.|..|...:.|:|:||...::.:...|.| |...:......
Mouse   331 QVIGSHRLPTLDDRTKMPYTDAVIHEIQRFTDLAPIGLPHKVTKDTLFRGYLIPKNTEVYPILSS 395

  Fly   463 AIHMDPVAFPEPEEFRPERFLTADGAYQAPPQFIPFSSGYRMCPGEEMARMILTLFTGRILRRFH 527
            |:| ||..|.:|:.|.||.||.|:||.:....|:|||:|.|:|.||.:||..|.||...||:.|.
Mouse   396 ALH-DPRYFEQPDSFNPEHFLDANGALKTNEAFMPFSTGKRICLGEGIARNELFLFFTTILQNFS 459

  Fly   528 LELPSGTE-VDM-AGESGITLTPTPHMLRF 555
            |..|...| :|: ...||.|.||..:.:.|
Mouse   460 LASPVAPENIDLIPNNSGATKTPPQYQIHF 489

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
phtm	NP_573319.1	CYP306A1-like	81..553	CDD:410745	130/486 (27%)
Cyp2b19	NP_031840.1	CYP2B	63..487	CDD:410765	131/487 (27%)