DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment phm and Cyp2a12

DIOPT Version :9

Sequence 1:	NP_001285414.1	Gene:	phm / 32857	FlyBaseID:	FBgn0004959	Length:	574	Species:	Drosophila melanogaster
Sequence 2:	NP_598418.1	Gene:	Cyp2a12 / 13085	MGIID:	105055	Length:	492	Species:	Mus musculus

Alignment Length:	557	Identity:	134/557 - (24%)
Similarity:	240/557 - (43%)	Gaps:	83/557 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 LSILLVPGALVLVILYLCERQCNDLMGAPPPGPWGLPFLGYLPFLDARAPHKSLQKLAKRYGGIF 84
            |:||.....:|||.::.     ..:.|..||||..|||:|....|:.:..:.|:.:|.:.||.:|
Mouse     9 LAILAFLSVMVLVSVWQ-----QKIRGKLPPGPIPLPFIGNYLQLNRKDVYSSITQLQEHYGPVF 68

  Fly    85 ELKMGRVPTVVLSDAALVRDFF--RRDVMTGRAPLYLTHGIMGGFGIICAQEDIWRHARRETIDW 147
            .:.:|....|||.....|::..  ..:..:||......:.:..|:|:..:..:..:..||.:|..
Mouse    69 TIHLGPRRVVVLYGYDAVKEALVDHAEEFSGRGEQATFNTLFKGYGVAFSNGERAKQLRRFSIAT 133

  Fly   148 LKALGMTRRPGELRARLERRIARGVDECVRLFDTEAKKSCASEVNPLPALHHSLGNIINDLVFGI 212
            |:..||.:|      .:|.||.......:::.    :.:|.:.::|...|..:..|:|:.:|||.
Mouse   134 LRDFGMGKR------GVEERIQEEAGCLIKML----QGTCGAPIDPTIYLSKTASNVISSIVFGD 188

  Fly   213 TYKRDDPDWLYLQRLQEEGVKLIGVSGVVNFLPWLRHLPANVRNIRFLLEGKAKTHAIYDRIVEA 277
            .:..:|.::|          .|:.:.|.||               :|   ..:.|..:||.....
Mouse   189 RFNYEDKEFL----------SLLQMMGQVN---------------KF---AASPTGQLYDMFHSV 225

  Fly   278 CGQRLKEKQKVFKELQEQKRLQRQLEKEQLRQSKEADPSQEQSEADEDDEESDEEDTYEPECILE 342
            .......:|::.|:       ..:||...:::.|     |.||..|.:          .|...::
Mouse   226 MKYLPGPQQQIIKD-------SHKLEDFMIQKVK-----QNQSTLDPN----------SPRDFID 268

  Fly   343 HFLAVRDTDSQLYCDDQLRHLL---ADLFGAGVDTSLATLRWFLLYLAREQRCQRRLHE---LLL 401
            .||.....:..:..:..:::|:   .:||.||.:|..:|||:..|.|.:....:.::||   .::
Mouse   269 SFLIHMQKEKYVNSEFHMKNLVMTSLNLFFAGSETVSSTLRYGFLLLMKHPDVEAKVHEEIDRVI 333

  Fly   402 PLGPSPTLEELEPLAYLRACISETMRIRSVVPLGIPHGCKENFVVGDYFIKGGSMIVCSEWAIHM 466
            .....|..|:...:.|.:|.|:|..|..:..|||||....::.....:|:..|:.:.....::..
Mouse   334 GRNRQPQYEDHMKMPYTQAVINEIQRFSNFAPLGIPRRITKDTSFRGFFLPKGTEVFPILGSLMT 398

  Fly   467 DPVAFPEPEEFRPERFLTADGAYQAPPQFIPFSSGYRMCPGEEMARMILTLFTGRILRRFHLELP 531
            ||..|..|::|.|:.||...|..:..|.|:|||:|.|.|.|:.:|:|.|.||...||:.|..:.|
Mouse   399 DPKFFSSPKDFNPQHFLDDKGQLKKIPAFLPFSTGKRFCLGDSLAKMELFLFFTTILQNFRFKFP 463

  Fly   532 SGTEVDMAGESGITLTPTPHMLRFTK-LPAVEMRHAP 567
            ...|       .|..:|||.  .||: :|...|...|
Mouse   464 RKLE-------DINESPTPE--GFTRIIPKYTMSFVP 491

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
phm	NP_001285414.1	p450	49..555	CDD:278495	122/513 (24%)
Cyp2a12	NP_598418.1	p450	33..489	CDD:278495	126/524 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000008
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.000