Protein Alignment phtm and Cyp21a1

DIOPT Version :10

• Sequence 1: NP_573319.1
• Gene: phtm / 32857
• FlyBaseID: FBgn0004959
• Length: 574
• Species: Drosophila melanogaster
• Sequence 2: NP_034125.2
• Gene: Cyp21a1 / 13079
• MGIID: 88591
• Length: 487
• Species: Mus musculus
• Alignment Length: 594
• Identity: 146/594 - (24%)
• Similarity: 232/594 - (39%)
• Gaps: 154/594 - (25%)

  Fly    23 LLVPGALVLVILYLCERQCNDLMG--------APPPGPWGLPFLGYLPFLDARAPHKSLQKLAKR 79
            :|:||.|:|::|....|.   |.|        .||..|      |:|.||....| ..|..|.::
Mouse     1 MLLPGLLLLLLLLAGTRW---LWGQWKLRKLHLPPLAP------GFLHFLQPNLP-IYLLGLTQK 55

  Fly    80 YGGIFELKMGRVPTVVLS-----DAALVR---DFF-RRDVMTGRAPLYLTHGIMGGFGIICAQED 135
            .|.|:.:::|....|||:     :.||::   ||. |..::.|:..|.|:   :|.:.:
Mouse    56 LGPIYRIRLGMQDVVVLNSNRTIEEALIQKWVDFAGRPHMLNGKMDLDLS---LGDYSL------ 111

  Fly   136 IWRHARRETIDWLKALGMTRRPGELRARLERRIARGVDE-CVRLFDTEAKKSCASEVNPLPALHH 199
            :|: |.::.......|||       |..:|..|.:...| |.|:         .::.....|:|.
Mouse   112 MWK-AHKKLSRSALMLGM-------RDSMEPLIEQLTQEFCERM---------RAQAGTPVAIHK 159

  Fly   200 SLG----NIINDLVFGITYKRDDPDWLYLQRLQEEGVKLIGVSG-----VVNFLPWLRHLPANVR 255
            ...    :||:.|.||      |.|...:|.|.:....|:....     ::..:|.||.||.
Mouse   160 EFSFLTCSIISCLTFG------DKDSTLVQTLHDCVQDLLQAWNHWSIQILTIIPLLRFLPN--- 215

  Fly   256 NIRFLLEGKAKTHAIYDRIVEACGQRLKEKQKVFKELQEQKRLQRQLEKEQLRQSKEA------- 313
                  .|..|                      .|::||.:   ..:.|:||::.|::
Mouse   216 ------PGLQK----------------------LKQIQESR---DHIVKQQLKRHKDSLVAGQWK 249

  Fly   314 ---DPSQEQSEADEDDEESDEEDTYEPECILEHFLAVRDTDSQLYCDDQLRHL-LADLFGAGVDT 374
               |...:..|...|.:  |||..:|...                      |: :.|||..|.:|
Mouse   250 DMIDYMLQGVEKQRDGK--DEERLHEGHV----------------------HMSVVDLFIGGTET 290

  Fly   375 SLATLRWFLLYLAREQRCQRRLHELL-LPLGPSPTL--EELEPLAYLRACISETMRIRSVVPLGI 436
            :..||.|.:.:|......|:||.|.| |.|||...|  .....|..|.|.|:|.:|:|.||||.:
Mouse   291 TATTLSWAVAFLLHHPEIQKRLQEELDLKLGPGSQLLYRNRMQLPLLMATIAEVLRLRPVVPLAL 355

  Fly   437 PHGCKENFVVGDYFIKGGSMIVCSEWAIHMDPVAFPEPEEFRPERFLTADGAYQAPPQFIPFSSG 501
            ||.......:..|.|....:|:.:....::|.:.:..|.:|.|:|||......:.|    .|..|
Mouse   356 PHRATRASSISGYDIPKDMVIIPNIQGANLDEMVWELPSKFWPDRFLEPGKNPRTP----SFGCG 416

  Fly   502 YRMCPGEEMARMILTLFTGRILRRFH-LELPSGTEVDMAGESGITLTPTPHMLRFTKLPAVEMRH 565
            .|:|.||.:||:.|.:...|:|:.|. |..|.||..        :|.|.|:......:|..::|.
Mouse   417 ARVCLGEPLARLELFVVLARLLQAFTLLPPPDGTLP--------SLQPQPYAGINLPIPPFQVRL 473

  Fly   566 APDGAVVQD 574
            .|.....||
Mouse   474 QPRNLAPQD 482

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
phtm	NP_573319.1	CYP306A1-like	81..553	CDD:410745	122/505 (24%)
Cyp21a1	NP_034125.2	CYP21	56..474	CDD:410767	124/519 (24%)