Protein Alignment phtm and CYP2R1

DIOPT Version :10

• Sequence 1: NP_573319.1
• Gene: phtm / 32857
• FlyBaseID: FBgn0004959
• Length: 574
• Species: Drosophila melanogaster
• Sequence 2: NP_078790.2
• Gene: CYP2R1 / 120227
• HGNCID: 20580
• Length: 501
• Species: Homo sapiens
• Alignment Length: 551
• Identity: 149/551 - (27%)
• Similarity: 243/551 - (44%)
• Gaps: 94/551 - (17%)

  Fly    27 GALVLVILYLCERQC---NDLMGAPPPGPWGLPFLGYLPFLDARA--PHKSLQKLAKRYGGIFEL 86
            |||.|::..|..||.   ...||. ||||.||||:|.:..|.|.:  ||..::|.::.||.||.|
Human    16 GALFLLLFALGVRQLLKQRRPMGF-PPGPPGLPFIGNIYSLAASSELPHVYMRKQSQVYGEIFSL 79

  Fly    87 KMGRVPTVVLSDAALVRD--FFRRDVMTGR--APLYLTHGIMGGF-------GIICAQEDIWRHA 140
            .:|.:.||||:...:|::  ..:.::...|  .||::....|||.       |        |...
Human    80 DLGGISTVVLNGYDVVKECLVHQSEIFADRPCLPLFMKMTKMGGLLNSRYGRG--------WVDH 136

  Fly   141 RRETIDWLKALGMTRRPGELRARLERRIARGVDECV--RLFDTEAKKSCASEVNPLPALHHSLGN 203
            ||..::..:..|..::..|.:...|.:......|..  |.||.:            ..:.:::.|
Human   137 RRLAVNSFRYFGYGQKSFESKILEETKFFNDAIETYKGRPFDFK------------QLITNAVSN 189

  Fly   204 IINDLVFGITYKRDDPDWLYLQRLQEEGVKLIGVSGV--VNFLPWLRHLPANVRNIRFLLEGKAK 266
            |.|.::||..:..:|.|:.::..|..|.|:|...:.|  .|..||:..||.......|     ..
Human   190 ITNLIIFGERFTYEDTDFQHMIELFSENVELAASASVFLYNAFPWIGILPFGKHQQLF-----RN 249

  Fly   267 THAIYDRIVEACGQRLKEKQKVFKELQEQKRLQRQLEKEQLRQSKEADPSQEQSEADEDDE-ESD 330
            ...:||                        .|.|.:||..:.:..:.......:..||.|: ::|
Human   250 AAVVYD------------------------FLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKND 290

  Fly   331 EEDTYEPECILEHFLAVRDTDSQLYCDDQLRHLLADLFGAGVDTSLATLRWFLLYLAREQRCQRR 395
            ...|:..|                    .|...:.:|..||.:|:...|||.:|::|.....|.:
Human   291 PSSTFSKE--------------------NLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQ 335

  Fly   396 LH-ELLLPLGPS--PTLEELEPLAYLRACISETMRIRSVVPLGIPHGCKENFVVGDYFIKGGSMI 457
            :. |:.|.:||:  |:.::...:.|..|.:.|.:|..::|||||.|...|:.||..|.|..|:.:
Human   336 VQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTV 400

  Fly   458 VCSEWAIHMDPVAFPEPEEFRPERFLTADGAYQAPPQFIPFSSGYRMCPGEEMARMILTLFTGRI 522
            :.:.:::|.|...:.:||.|.|||||.:.|.:......:|||.|.|.|.||.:|||.:.||...:
Human   401 ITNLYSVHFDEKYWRDPEVFHPERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTAL 465

  Fly   523 LRRFHLELPSGTEVDMAGESGITLTPTPHML 553
            |:||||..|.....|:....|:||.|.|:::
Human   466 LQRFHLHFPHELVPDLKPRLGMTLQPQPYLI 496

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
phtm	NP_573319.1	CYP306A1-like	81..553	CDD:410745	125/490 (26%)
CYP2R1	NP_078790.2	CYP2R1	62..497	CDD:410754	129/504 (26%)