Protein Alignment phm and CYP2U1

DIOPT Version :9

• Sequence 1: NP_001285414.1
• Gene: phm / 32857
• FlyBaseID: FBgn0004959
• Length: 574
• Species: Drosophila melanogaster
• Sequence 2: XP_005262774.1
• Gene: CYP2U1 / 113612
• HGNCID: 20582
• Length: 562
• Species: Homo sapiens
• Alignment Length: 590
• Identity: 162/590 - (27%)
• Similarity: 254/590 - (43%)
• Gaps: 122/590 - (20%)

  Fly    27 GALVLVIL-------YLCERQCNDLMGAPP-PGPWGL----------PFLGYLPFLDAR------ 67
            |||:|..|       :|..|:..   |.|| |.||.|          |||....:|.:|
Human    35 GALLLCGLVALLGWSWLRRRRAR---GIPPGPTPWPLVGNFGHVLLPPFLRRRSWLSSRTRAAGI 96

  Fly    68 -----APHKSLQKLAKRYGGIFELKMGRVPTVVLSDAALVRDFF--RRDVMTGRAPLYL------ 119
                 .|...|..||:.||.||...:|....|||||...||:..  :.:|.:.|..:.|
Human    97 DPSVIGPQVLLAHLARVYGSIFSFFIGHYLVVVLSDFHSVREALVQQAEVFSDRPRVPLISIVTK 161

  Fly   120 ---THGIMG-GF--------GIICAQ-EDIWRHARRETIDWLKALGMTRRPGELRARLERRIARG 171
               ...::| |:        |::.|. ..:||..|:.:...|:..|:    |:|  .||.:|
Human   162 EKGEREVVGCGYADAADESPGVVFAHYGPVWRQQRKFSHSTLRHFGL----GKL--SLEPKI--- 217

  Fly   172 VDECVRLFDTEAKKSCASEVNPLPALHHSLGNIINDLVFGITYKRDDPDWLYLQRLQEEGVKLIG 236
            ::| .:....|.:|.......|...:.:::.|||..|.||..:...:.::..:......|:::..
Human   218 IEE-FKYVKAEMQKHGEDPFCPFSIISNAVSNIICSLCFGQRFDYTNSEFKKMLGFMSRGLEICL 281

  Fly   237 VSGV--VNFLPWLRHLPANVRNIRFLLEGKAKTHAIYDRIVEACGQRLKEKQKVFKELQEQKRLQ 299
            .|.|  ||..|||.:||..                                  .||||
Human   282 NSQVLLVNICPWLYYLPFG----------------------------------PFKEL------- 305

  Fly   300 RQLEKEQLRQSKEADPSQEQSEADEDDEESDEE--DTYEPECILEHFLAVRDTDSQLYCDDQ-LR 361
            ||:||:.....|:.....::|.    |.|:.::  |.|     |.|....|..:|....|:: |.
Human   306 RQIEKDITSFLKKIIKDHQESL----DRENPQDFIDMY-----LLHMEEERKNNSNSSFDEEYLF 361

  Fly   362 HLLADLFGAGVDTSLATLRWFLLYLAREQRCQRRLH---ELLLPLGPSPTLEELEPLAYLRACIS 423
            :::.|||.||.||:..:|.|.|||::.....|.::|   |.::....:|:|.:...:.|..|.|.
Human   362 YIIGDLFIAGTDTTTNSLLWCLLYMSLNPDVQEKVHEEIERVIGANRAPSLTDKAQMPYTEATIM 426

  Fly   424 ETMRIRSVVPLGIPHGCKENFVVGDYFIKGGSMIVCSEWAIHMDPVAFPEPEEFRPERFLTADGA 488
            |..|:..||||.|||...||.|:..|.|..|::|:.:.|::|.||..:.:||:|.|.|||...|.
Human   427 EVQRLTVVVPLAIPHMTSENTVLQGYTIPKGTLILPNLWSVHRDPAIWEKPEDFYPNRFLDDQGQ 491

  Fly   489 YQAPPQFIPFSSGYRMCPGEEMARMILTLFTGRILRRFHLELPSGTEVD-MAGESGITLTPTPHM 552
            ......||||..|.|:|.||::|:|.|.|....:::.|...||..::.. :.|..|:||.|.|..
Human   492 LIKKETFIPFGIGKRVCMGEQLAKMELFLMFVSLMQSFAFALPEDSKKPLLTGRFGLTLAPHPFN 556

  Fly   553 LRFTK 557
            :..::
Human   557 ITISR 561

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
phm	NP_001285414.1	p450	49..555	CDD:278495	153/557 (27%)
CYP2U1	XP_005262774.1	p450	60..555	CDD:278495	153/554 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000008
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24300
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	5.010