DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6696 and BMP1

DIOPT Version :9

Sequence 1:	NP_573318.1	Gene:	CG6696 / 32856	FlyBaseID:	FBgn0030947	Length:	324	Species:	Drosophila melanogaster
Sequence 2:	NP_006120.1	Gene:	BMP1 / 649	HGNCID:	1067	Length:	986	Species:	Homo sapiens

Alignment Length:	240	Identity:	76/240 - (31%)
Similarity:	119/240 - (49%)	Gaps:	27/240 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    80 CGLFEGDIMLHRELLRNGLLN--ERLTWPEAAVPFYIDPQDFNANQTMVILKAFKEYHDRTCIRF 142
            ||.:.|     |...|....:  ||: ||:..:||.|. .:|..:|..|..:|.:.:...||:.|
Human   109 CGRWRG-----RSRSRRAATSRPERV-WPDGVIPFVIG-GNFTGSQRAVFRQAMRHWEKHTCVTF 166

  Fly   143 RPYEQGDK-HWLLIKGNYSGCWSSVGRRSGG-QVLNLNTPKCVTHGVVVHELLHALGFYHQQSAT 205
              .|:.|: .:::......||.|.||||.|| |.:::. ..|...|:|||||.|.:||:|:.:..
Human   167 --LERTDEDSYIVFTYRPCGCCSYVGRRGGGPQAISIG-KNCDKFGIVVHELGHVVGFWHEHTRP 228

  Fly   206 ERDEYVKINWENILDGHAHNFNKYARTHITNFGVEYDYQSVMHYSSRAFSKN-------GKATIE 263
            :||.:|.|..|||..|..:||.|.....:.:.|..||:.|:|||:...||:.       .|..:.
Human   229 DRDRHVSIVRENIQPGQEYNFLKMEPQEVESLGETYDFDSIMHYARNTFSRGIFLDTIVPKYEVN 293

  Fly   264 PLDPYASLGQRRGLSDKDVSKLNEMYE-QDCSEDYLLNFDRFGNY 307
            .:.|  .:|||..||..|:::..::|: ..|.|...   |..||:
Human   294 GVKP--PIGQRTRLSKGDIAQARKLYKCPACGETLQ---DSTGNF 333

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6696	NP_573318.1	Astacin	104..295	CDD:279708	65/200 (33%)
CG6696	NP_573318.1	ZnMc_astacin_like	110..289	CDD:239807	61/187 (33%)
BMP1	NP_006120.1	ZnMc_BMP1_TLD	121..320	CDD:239808	66/205 (32%)
		Astacin	128..321	CDD:279708	65/199 (33%)
		CUB	322..431	CDD:278839	5/15 (33%)
		CUB	435..544	CDD:278839
		FXa_inhibition	555..587	CDD:291342
		CUB	591..700	CDD:278839
		FXa_inhibition	707..742	CDD:291342
		CUB	747..856	CDD:278839
		CUB	860..973	CDD:278839
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3714
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810