DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6696 and MEP1B

DIOPT Version :9

Sequence 1:	NP_573318.1	Gene:	CG6696 / 32856	FlyBaseID:	FBgn0030947	Length:	324	Species:	Drosophila melanogaster
Sequence 2:	NP_005916.2	Gene:	MEP1B / 4225	HGNCID:	7020	Length:	701	Species:	Homo sapiens

Alignment Length:	224	Identity:	99/224 - (44%)
Similarity:	131/224 - (58%)	Gaps:	14/224 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    82 LFEGDIMLHRELLRNGLLNERLTWPEAAVPFYI-DPQDFNANQTMVILKAFKEYHDRTCIRFRPY 145
            ||||||.|.|..:||.::.|:..||. .:|:.: |..:.||..  |||.||:.|..:|||.|:|:
Human    48 LFEGDIRLDRAQIRNSIIGEKYRWPH-TIPYVLEDSLEMNAKG--VILNAFERYRLKTCIDFKPW 109

  Fly   146 EQGDKHWLLIKGNYSGCWSSVG-RRSGGQVLNLNTPKCVTHGVVVHELLHALGFYHQQSATERDE 209
            .....:..:.||  |||||||| ||.|.|.|::.. .|.....|.||.||||||:|:||.::||:
Human   110 AGETNYISVFKG--SGCWSSVGNRRVGKQELSIGA-NCDRIATVQHEFLHALGFWHEQSRSDRDD 171

  Fly   210 YVKINWENILDGHAHNFNKYARTHITNFGVEYDYQSVMHYSSRAFSKNGKATI--EPLDPYASLG 272
            ||:|.|:.||.|..||||.|:.....:..|.|||.||||||..||....:.||  ...|....:|
Human   172 YVRIMWDRILSGREHNFNTYSDDISDSLNVPYDYTSVMHYSKTAFQNGTEPTIVTRISDFEDVIG 236

  Fly   273 QRRGLSDKDVSKLNEMYEQDCSEDYLLNF 301
            ||...||.|:.|||::|  :||..  |:|
Human   237 QRMDFSDSDLLKLNQLY--NCSSS--LSF 261

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6696	NP_573318.1	Astacin	104..295	CDD:279708	85/194 (44%)
CG6696	NP_573318.1	ZnMc_astacin_like	110..289	CDD:239807	81/182 (45%)
MEP1B	NP_005916.2	ZnMc_meprin	26..255	CDD:239809	95/214 (44%)
		Astacin	69..257	CDD:279708	85/195 (44%)
		MAM	260..427	CDD:214533	1/2 (50%)
		MAM	265..427	CDD:99706
		MATH	427..586	CDD:295307
		Required for proteolytic processing	595..607
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	146	1.000	Domainoid score	I4542
eggNOG	1	0.900	-	-		E1_KOG3714
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H48382
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8634
orthoMCL	1	0.900	-	-		OOG6_108702
Panther	1	1.100	-	-	O	PTHR10127
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2664
SonicParanoid	1	1.000	-	-		X245
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.840