DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6696 and Astl

DIOPT Version :9

Sequence 1:	NP_573318.1	Gene:	CG6696 / 32856	FlyBaseID:	FBgn0030947	Length:	324	Species:	Drosophila melanogaster
Sequence 2:	NP_001099974.1	Gene:	Astl / 296129	RGDID:	1562279	Length:	436	Species:	Rattus norvegicus

Alignment Length:	240	Identity:	88/240 - (36%)
Similarity:	128/240 - (53%)	Gaps:	21/240 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 PAFNFWTEDSDTNIWEHCGLFEGDIMLHRELLRNGLLNERLTWPEAA-----VPFYIDPQDFNAN 122
            ||.|......:|.  |...|.||||:.........:.|.:  ||:..     :||.:..: ::..
  Rat    56 PAINQGLISEETP--ESSFLVEGDIIRPSPFRLLSVTNNK--WPKGVDGIVEIPFLLSSK-YDEP 115

  Fly   123 QTMVILKAFKEYHDRTCIRFRPYEQGDKHWLLIKGNYSGCWSSVGRRSGGQVLNLNTPKCVT--H 185
            ...||::||.|:...|||||..| :|.:.::.|. ..:||:|.|||..|.||::| .|.|:.  .
  Rat   116 SRQVIMEAFAEFERFTCIRFVAY-RGQRDFVSIL-PMAGCFSGVGRSGGMQVVSL-APTCLQKGR 177

  Fly   186 GVVVHELLHALGFYHQQSATERDEYVKINWENILDGHAHNFNKYARTHITNFGVEYDYQSVMHYS 250
            |:|:|||:|.|||:|:.|..:||.|:::||..||.|...||.|   :..:|....|||.|||||.
  Rat   178 GIVLHELMHVLGFWHEHSRADRDRYIRVNWNEILPGFEINFIK---SRNSNMLAPYDYSSVMHYG 239

  Fly   251 SRAFSKNGKATIEPL-DPYASLGQRRGLSDKDVSKLNEMYEQDCS 294
            ..|||..|:.||.|| .....:|||..||..|::::..:|  .||
  Rat   240 RFAFSWRGQPTIIPLWTSSVHIGQRWNLSTSDITRVCRLY--SCS 282

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6696	NP_573318.1	Astacin	104..295	CDD:279708	77/199 (39%)
CG6696	NP_573318.1	ZnMc_astacin_like	110..289	CDD:239807	72/181 (40%)
Astl	NP_001099974.1	Astacin	92..283	CDD:279708	77/202 (38%)
		ZnMc	99..281	CDD:294052	73/190 (38%)
		ImpA_N	<305..420	CDD:303075
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166353351
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3714
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	150	1.000	Inparanoid score	I4289
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D472790at33208
OrthoFinder	1	1.000	-	-		FOG0000240
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10127
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X245
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.900