DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6696 and Mep1b

DIOPT Version :9

Sequence 1:	NP_573318.1	Gene:	CG6696 / 32856	FlyBaseID:	FBgn0030947	Length:	324	Species:	Drosophila melanogaster
Sequence 2:	NP_037315.1	Gene:	Mep1b / 25727	RGDID:	3081	Length:	704	Species:	Rattus norvegicus

Alignment Length:	253	Identity:	100/253 - (39%)
Similarity:	138/253 - (54%)	Gaps:	20/253 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 PAFNFWTEDSD-------TNIWEHCG--LFEGDIMLHRELLRNGLLNERLTWPEAAVPFYI-DPQ 117
            ||...:.:|.|       .:|.|..|  ||||||.|... .||.::.:...||. .:|:.: |..
  Rat    22 PAPEKFVKDIDGGIDQDIFDINEDLGLDLFEGDIKLEAS-GRNSIIGDNYRWPH-TIPYVLEDSL 84

  Fly   118 DFNANQTMVILKAFKEYHDRTCIRFRPYEQGDKHWLLIKGNYSGCWSSVGR-RSGGQVLNLNTPK 181
            :.||..  |||.||:.|..:|||.|:|:...:.:..:.||  ||||||||. .:|.|.|::.| .
  Rat    85 EMNAKG--VILNAFERYRLKTCIDFKPWSGEENYISVFKG--SGCWSSVGNIHAGKQELSIGT-N 144

  Fly   182 CVTHGVVVHELLHALGFYHQQSATERDEYVKINWENILDGHAHNFNKYARTHITNFGVEYDYQSV 246
            |.....|.||.||||||:|:||..:||:|:.|.|:.||.|..||||.|..:...:..|.|||.||
  Rat   145 CDRIATVQHEFLHALGFWHEQSRADRDDYITIVWDRILSGKEHNFNIYNDSVSDSLNVPYDYTSV 209

  Fly   247 MHYSSRAFSKNGKATI--EPLDPYASLGQRRGLSDKDVSKLNEMYEQDCSEDYLLNFD 302
            ||||..||....::||  :..|....:|||...||.|:.|||::|....|..::.:.|
  Rat   210 MHYSKTAFQNGTESTIITKISDFEDVIGQRMDFSDYDLLKLNQLYSCTSSLSFMDSCD 267

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6696	NP_573318.1	Astacin	104..295	CDD:279708	82/194 (42%)
CG6696	NP_573318.1	ZnMc_astacin_like	110..289	CDD:239807	79/182 (43%)
Mep1b	NP_037315.1	ZnMc	30..256	CDD:294052	96/232 (41%)
		Astacin	70..258	CDD:279708	82/193 (42%)
		MAM	266..430	CDD:279023	1/2 (50%)
		MAM	266..428	CDD:99706	1/2 (50%)
		MATH	428..586	CDD:295307
		EGF_CA	609..647	CDD:238011
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	149	1.000	Domainoid score	I4301
eggNOG	1	0.900	-	-		E1_KOG3714
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H48382
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm46196
orthoMCL	1	0.900	-	-		OOG6_108702
Panther	1	1.100	-	-	O	PTHR10127
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X245
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.810