DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6696 and Tll2

DIOPT Version :9

Sequence 1:	NP_573318.1	Gene:	CG6696 / 32856	FlyBaseID:	FBgn0030947	Length:	324	Species:	Drosophila melanogaster
Sequence 2:	NP_036034.1	Gene:	Tll2 / 24087	MGIID:	1346044	Length:	1012	Species:	Mus musculus

Alignment Length:	283	Identity:	79/283 - (27%)
Similarity:	127/283 - (44%)	Gaps:	45/283 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 AARW------GANMQMLRRHNSPAFNFWTEDSDTNIWEHCGLFEGDIMLHRELLRNGLLNERLTW 105
            :|||      .|::|..|:....|..|......:|.       .......|.........||: |
Mouse   100 SARWPNDTASNASIQAPRKDGKDATTFLPNPGTSNT-------TAKTFSARVRRATTSRTERI-W 156

  Fly   106 PEAAVPFYIDPQDFNANQTMVILKAFKEYHDRTCIRFRPYEQGDKH-WLLIKGNYSGCWSSVGRR 169
            |...:| |:...:|...|..:..:|.:.:...||:.|  .|:.|:. :::......||.|.||||
Mouse   157 PGGVIP-YVIGGNFTGTQRAIFKQAMRHWEKHTCVTF--VERTDEESFIVFSYRTCGCCSYVGRR 218

  Fly   170 SGG-QVLNLNTPKCVTHGVVVHELLHALGFYHQQSATERDEYVKINWENILDGHAHNFNKYARTH 233
            .|| |.:::. ..|...|:|.|||.|.:||:|:.:..:||::|.|..|||..|..:||.|.....
Mouse   219 GGGPQAISIG-KNCDKFGIVAHELGHVVGFWHEHTRPDRDQHVTIIRENIQPGQEYNFLKMEAGE 282

  Fly   234 ITNFGVEYDYQSVMHYSSRAFSK-------------NGKATIEPLDPYASLGQRRGLSDKDVSKL 285
            :::.|..||:.|:|||:...||:             ||   :.|     ::|||..||..|:::.
Mouse   283 VSSLGETYDFDSIMHYARNTFSRGVFLDTILPRRDDNG---VRP-----TIGQRVRLSQGDIAQA 339

  Fly   286 NEMYE-QDCSEDYLLNFDRFGNY 307
            .::|: ..|.|...   |..||:
Mouse   340 RKLYKCPACGETLQ---DTTGNF 359

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6696	NP_573318.1	Astacin	104..295	CDD:279708	63/206 (31%)
CG6696	NP_573318.1	ZnMc_astacin_like	110..289	CDD:239807	59/193 (31%)
Tll2	NP_036034.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	83..135		8/34 (24%)
		ZnMc_BMP1_TLD	147..346	CDD:239808	64/211 (30%)
		Astacin	154..347	CDD:279708	63/205 (31%)
		CUB	348..457	CDD:278839	5/15 (33%)
		CUB	461..570	CDD:278839
		FXa_inhibition	581..613	CDD:291342
		CUB	617..726	CDD:278839
		FXa_inhibition	733..768	CDD:291342
		CUB	773..882	CDD:278839
		CUB	886..999	CDD:278839
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3714
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810