DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6696 and Astl

DIOPT Version :9

Sequence 1:	NP_573318.1	Gene:	CG6696 / 32856	FlyBaseID:	FBgn0030947	Length:	324	Species:	Drosophila melanogaster
Sequence 2:	NP_001277932.1	Gene:	Astl / 215095	MGIID:	3046414	Length:	435	Species:	Mus musculus

Alignment Length:	294	Identity:	98/294 - (33%)
Similarity:	146/294 - (49%)	Gaps:	28/294 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 PGLICFWSALALALSATLEASTPATRKALLRARPAVPPAARWGANMQMLRRHNSPAFNFWTEDSD 73
            |.::...|.|.|::.|      |:..:.......:||.... .....:.:..:.||.|......:
Mouse     9 PWILTMLSLLGLSMGA------PSASRCSGVCSTSVPEGFT-PEGSPVFQDKDIPAINQGLISEE 66

  Fly    74 TNIWEHCGLFEGDIMLHRELLRNGLLNERLTWPEAA-----VPFYIDPQDFNANQTMVILKAFKE 133
            |.  |...|.||||:.........:.|.:  ||:..     :||.:. :.::.....||:.||.|
Mouse    67 TP--ESSFLVEGDIIRPSPFRLLSVTNNK--WPKGVGGFVEIPFLLS-RKYDELSRRVIMDAFAE 126

  Fly   134 YHDRTCIRFRPYEQGDKHWLLIKGNYSGCWSSVGRRSGGQVLNLNTPKCVT--HGVVVHELLHAL 196
            :...|||||..| .|.:.::.|. ..:||:|.|||..|.||::| .|.|:.  .|:|:|||:|.|
Mouse   127 FERFTCIRFVAY-HGQRDFVSIL-PMAGCFSGVGRSGGMQVVSL-APTCLRKGRGIVLHELMHVL 188

  Fly   197 GFYHQQSATERDEYVKINWENILDGHAHNFNKYARTHITNFGVEYDYQSVMHYSSRAFSKNGKAT 261
            ||:|:.|..:||.|:::||..||.|...||.|   :..||..|.|||.|||||...|||..|:.|
Mouse   189 GFWHEHSRADRDRYIQVNWNEILPGFEINFIK---SRSTNMLVPYDYSSVMHYGRFAFSWRGQPT 250

  Fly   262 IEPL-DPYASLGQRRGLSDKDVSKLNEMYEQDCS 294
            |.|| .....:|||..||..|::::..:|  :||
Mouse   251 IIPLWTSSVHIGQRWNLSTSDITRVCRLY--NCS 282

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6696	NP_573318.1	Astacin	104..295	CDD:279708	79/199 (40%)
CG6696	NP_573318.1	ZnMc_astacin_like	110..289	CDD:239807	74/181 (41%)
Astl	NP_001277932.1	Astacin	92..282	CDD:279708	77/200 (39%)
		ZnMc	100..281	CDD:294052	75/189 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	318..356
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167849692
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3714
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	152	1.000	Inparanoid score	I4329
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000240
OrthoInspector	1	1.000	-	-		otm44135
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10127
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2664
SonicParanoid	1	1.000	-	-		X245
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.920