DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6696 and nas-27

DIOPT Version :9

Sequence 1:	NP_573318.1	Gene:	CG6696 / 32856	FlyBaseID:	FBgn0030947	Length:	324	Species:	Drosophila melanogaster
Sequence 2:	NP_493926.2	Gene:	nas-27 / 188809	WormBaseID:	WBGene00003545	Length:	428	Species:	Caenorhabditis elegans

Alignment Length:	270	Identity:	73/270 - (27%)
Similarity:	131/270 - (48%)	Gaps:	35/270 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 LLRARPAVPPAARWGANMQMLRRHNSPAFNFWTEDSDTNIWEHCG--LFEGDIMLHRELLRNGLL 99
            |:.:..|:|...|      .:|..|         :.|.|.....|  |::|||.:.:...|..::
Worm    11 LITSLHAIPRGRR------AVRNRN---------EGDINSLVGVGQYLYQGDIAVVKSRARRAVI 60

  Fly   100 NERLTWPEAAVPFYIDPQDFNANQTMVILKAFKEYHDRTCIRFRPYEQGDKHWLLIKGNYSGCWS 164
            .::....:..:|:..| ::|.:.....:|:|.:.:.::||:.|........|..:.:||  ||||
Worm    61 RQKHKKWKLPMPYSFD-RNFPSRSRQRVLEAMQFWSEKTCVTFHENRYVYPHVSIFEGN--GCWS 122

  Fly   165 SVGRRSGGQVLNLNTPK-CVTHG-VVVHELLHALGFYHQQSATERDEYVKINWENILDGHAHNFN 227
            .||::...:..:|:..: |..|. ||.||:.|.|||||:.:..:||:::.|::.|:.......|.
Worm   123 FVGKQPSLREQSLSLERSCTDHTFVVAHEIAHTLGFYHEHARGDRDQFISIDYSNVNPNLTFAFA 187

  Fly   228 KYARTHITNFGVEYDYQSVMHYSSRAFSKNGKATIEPLDPYA-------SLGQRRGLSDKDVSKL 285
            |.:...:.:....|:|.||||||...|:.|   |..|: .||       ::|.|...:.:|||::
Worm   188 KESEKQLDHQEAAYEYGSVMHYSVDQFAVN---TNRPV-IYARDQKFAQAMGNRMRATFQDVSRM 248

  Fly   286 NEMYEQDCSE 295
            |.:|  :|.|
Worm   249 NVLY--NCHE 256

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6696	NP_573318.1	Astacin	104..295	CDD:279708	58/199 (29%)
CG6696	NP_573318.1	ZnMc_astacin_like	110..289	CDD:239807	56/187 (30%)
nas-27	NP_493926.2	Astacin	65..254	CDD:279708	57/197 (29%)
		ZnMc_astacin_like	70..252	CDD:239807	56/188 (30%)
		CUB	334..410	CDD:294042
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3714
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D681837at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10127
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920