DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6696 and nas-14

DIOPT Version :9

Sequence 1:	NP_573318.1	Gene:	CG6696 / 32856	FlyBaseID:	FBgn0030947	Length:	324	Species:	Drosophila melanogaster
Sequence 2:	NP_502533.2	Gene:	nas-14 / 184247	WormBaseID:	WBGene00003533	Length:	503	Species:	Caenorhabditis elegans

Alignment Length:	254	Identity:	99/254 - (38%)
Similarity:	142/254 - (55%)	Gaps:	33/254 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    71 DSDTNIWEHCGLFEGDIMLHRELLRNGLLNERL----------------------------TWPE 107
            |::....::..|||||||...|:.::.:| :||                            .|||
Worm    64 DAEIESMQNSLLFEGDIMGVPEIEKSDIL-KRLRDDPLLDEDEIFRKPFHSALNLVTYPDKLWPE 127

  Fly   108 AAVPFYIDPQDFNANQTMVILKAFKEYHDRTCIRFRPYEQGDKHWLLIKGNYS-GCWSSVGRRSG 171
            ..||:.:: :....:|...|.:||.||..:||:||.|....|..::.:|.|.: ||.|.|||..|
Worm   128 GQVPYMLE-EGMTNDQRTAIAQAFDEYKTKTCVRFVPKTDDDFDYIYVKRNVAFGCSSYVGRAGG 191

  Fly   172 GQVLNLNTPKCVTHGVVVHELLHALGFYHQQSATERDEYVKINWENILDGHAHNFNKYARTHITN 236
            .|.::|...||.:.|::.|||:|||||:|:.|.|:||::|.||.:||..|...||.||.|..|.:
Worm   192 NQTVSLEVDKCFSKGIIAHELMHALGFFHEHSRTDRDDFVDINEDNIRPGMMRNFEKYPRKIIDS 256

  Fly   237 FGVEYDYQSVMHYSSRAFSKNGKATIEPLDPYASLGQRRGLSDKDVSKLNEMYEQDCSE 295
            .|:.|||:|||||...|||:|||.||.|.|..|.:|||..||:.|..|:|::|:  |.|
Worm   257 LGMPYDYESVMHYHKLAFSRNGKPTIIPKDNEADVGQRYKLSEMDSKKVNKLYQ--CGE 313

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6696	NP_573318.1	Astacin	104..295	CDD:279708	86/191 (45%)
CG6696	NP_573318.1	ZnMc_astacin_like	110..289	CDD:239807	81/179 (45%)
nas-14	NP_502533.2	Astacin	123..313	CDD:279708	86/192 (45%)
		ZnMc_astacin_like	128..309	CDD:239807	81/181 (45%)
		ShKT	380..414	CDD:214586
		ShK	468..503	CDD:279838
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160166938
Domainoid	1	1.000	176	1.000	Domainoid score	I2159
eggNOG	1	0.900	-	-		E1_KOG3714
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D472790at33208
OrthoFinder	1	1.000	-	-		FOG0000240
OrthoInspector	1	1.000	-	-		mtm4830
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2664
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.780