DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6696 and nas-32

DIOPT Version :9

Sequence 1:	NP_573318.1	Gene:	CG6696 / 32856	FlyBaseID:	FBgn0030947	Length:	324	Species:	Drosophila melanogaster
Sequence 2:	NP_503351.3	Gene:	nas-32 / 178595	WormBaseID:	WBGene00003550	Length:	653	Species:	Caenorhabditis elegans

Alignment Length:	345	Identity:	91/345 - (26%)
Similarity:	131/345 - (37%)	Gaps:	74/345 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 FW---------SALALALSATLEASTPA-------------TRKALLRARPAVPPAAR------W 50
            ||         |..|...::|:..||.|             .||:|.:|...|||..|      .
Worm    62 FWKWTWNSRINSTTAATPTSTVTTSTSAPTTSPRVYKLKSEARKSLRKALRGVPPEKRKKQLKKM 126

  Fly    51 GANMQMLRR-------------------HNSPAFNFWTEDSDTNIWEHCGLFEGDIMLHRELL-- 94
            |..|..:.:                   .|.||.:.:..:....:.|:  ||:|||.|:...:
Worm   127 GKKMMKIPKITKKESNKLHKSYRKVKITENPPALDMFEVNERAGLNEY--LFQGDINLNNNQIAK 189

  Fly    95 ------------RNGLLNERLTWPEAAVPFYIDPQDFNANQTMVILKAFKEYHDRTCIRFRPYEQ 147
                        :..:.|....||...|.:|.| .........::..|.......||::|.....
Worm   190 ISSEQSSKSRRKKRQIDNLAQFWPGKVVYYYFD-SGLTTTVQQIVRDAITFLESNTCLKFELNST 253

  Fly   148 GDKHWLLIKGNYSGCWSSVGRRSGGQVLNLNTPKCVTHGVVVHELLHALGFYHQQSATERDEYVK 212
            ......:..|  .||:|..|...|.|.|:|.. .|...|...||:.|.||.:|.|..::||:||.
Worm   254 ATNRVKIFSG--VGCYSDTGMLGGEQTLSLGY-GCEVTGTAAHEIAHTLGLFHTQMRSDRDDYVT 315

  Fly   213 INWENILDGHAHNFNKYARTHITNFGVEYDYQSVMHYSSRAF-SKNGKATIEPLDP---YASLGQ 273
            |:..::.:....||.|......||. |:|:|.|.||||.||| |..|..:|.|.||   |...|
Worm   316 IDLTDVPESSQQNFIKLTEATSTNL-VDYEYGSFMHYSGRAFVSSGGVDSIVPKDPVMVYTMGG- 378

  Fly   274 RRGLSDKDVSKLNEMYEQDC 293
             |.::..|:..||..|...|
Worm   379 -RIVTFLDLKMLNTHYSCSC 397

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6696	NP_573318.1	Astacin	104..295	CDD:279708	62/194 (32%)
CG6696	NP_573318.1	ZnMc_astacin_like	110..289	CDD:239807	58/182 (32%)
nas-32	NP_503351.3	Astacin	210..397	CDD:279708	61/193 (32%)
		ZnMc_astacin_like	214..393	CDD:239807	58/185 (31%)
		CUB	464..>528	CDD:294042
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3714
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D681837at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10127
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.920