DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6696 and Mep1b

DIOPT Version :9

Sequence 1:	NP_573318.1	Gene:	CG6696 / 32856	FlyBaseID:	FBgn0030947	Length:	324	Species:	Drosophila melanogaster
Sequence 2:	NP_032612.2	Gene:	Mep1b / 17288	MGIID:	96964	Length:	704	Species:	Mus musculus

Alignment Length:	226	Identity:	92/226 - (40%)
Similarity:	130/226 - (57%)	Gaps:	13/226 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    82 LFEGDIMLHRELLRNGLLNERLTWPEAAVPFYI-DPQDFNANQTMVILKAFKEYHDRTCIRFRPY 145
            ||||||.|... .:|.::.:...||. .:|:.: |..:.||..  |||.||:.|..:|||.|:|:
Mouse    50 LFEGDIKLEAN-GKNSIIGDHKRWPH-TIPYVLEDSLEMNAKG--VILNAFERYRLKTCIDFKPW 110

  Fly   146 EQGDKHWL-LIKGNYSGCWSSVGR-RSGGQVLNLNTPKCVTHGVVVHELLHALGFYHQQSATERD 208
             .|:.::: :.||  ||||||||. .:|.|.|::.| .|.....|.||.||||||:|:||..:||
Mouse   111 -SGEANYISVFKG--SGCWSSVGNIHAGKQELSIGT-NCDRIATVQHEFLHALGFWHEQSRADRD 171

  Fly   209 EYVKINWENILDGHAHNFNKYARTHITNFGVEYDYQSVMHYSSRAFSKNGKATI-EPLDPYAS-L 271
            :||.|.|:.|..|..||||.|..:...:..|.|||.||||||..||....::|| ..:..:.. :
Mouse   172 DYVIIVWDRIQPGKEHNFNIYNDSVSDSLNVPYDYTSVMHYSKTAFQNGTESTIVTRISEFEDVI 236

  Fly   272 GQRRGLSDKDVSKLNEMYEQDCSEDYLLNFD 302
            |||...||.|:.|||::|....|..::.:.|
Mouse   237 GQRMDFSDYDLLKLNQLYNCTSSLSFMDSCD 267

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6696	NP_573318.1	Astacin	104..295	CDD:279708	82/195 (42%)
CG6696	NP_573318.1	ZnMc_astacin_like	110..289	CDD:239807	79/183 (43%)
Mep1b	NP_032612.2	ZnMc	30..256	CDD:294052	90/213 (42%)
		Astacin	70..258	CDD:279708	82/194 (42%)
		MAM	266..430	CDD:279023	1/2 (50%)
		MAM	266..428	CDD:99706	1/2 (50%)
		MATH	428..587	CDD:295307
		EGF_CA	609..647	CDD:238011
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	149	1.000	Domainoid score	I4395
eggNOG	1	0.900	-	-		E1_KOG3714
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H48382
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8881
orthoMCL	1	0.900	-	-		OOG6_108702
Panther	1	1.100	-	-	O	PTHR10127
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2664
SonicParanoid	1	1.000	-	-		X245
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.840