DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fu and Stk36

DIOPT Version :9

Sequence 1:	NP_477499.1	Gene:	fu / 32855	FlyBaseID:	FBgn0001079	Length:	805	Species:	Drosophila melanogaster
Sequence 2:	XP_006245236.1	Gene:	Stk36 / 301516	RGDID:	1307318	Length:	1365	Species:	Rattus norvegicus

Alignment Length:	883	Identity:	259/883 - (29%)
Similarity:	390/883 - (44%)	Gaps:	221/883 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MNRYAVSSMVGQGSFGCVYKATRKDDSKVVAIKVISKRGRATKELKNLRRECDIQARLKHPHVIE 65
            |.:|.|..|:|:||||.|||..:|..::|||:|.|.|.||:.|||:||:||.:|...|.||:::.
  Rat     1 MEKYHVLEMIGEGSFGRVYKGRKKYSAQVVALKFIPKLGRSEKELRNLQREIEIMRGLWHPNIVH 65

  Fly    66 MIESFESKTDLFVVTEFALMDLHRYLSYNGAMGEEPARRVTGHLVSALYYLHSNRILHRDLKPQN 130
            |::|||:..::.|||::|..:|.:.|..:|.:.||..:.:...||||||||||:||||||:||||
  Rat    66 MLDSFETDKEVVVVTDYAEGELFQILEDDGKLPEEQVQAIAAQLVSALYYLHSHRILHRDMKPQN 130

  Fly   131 VLLDKNMHAKLCDFGLARNMTLGTHVLTSIKGTPLYMAPELLAEQPYDHHADMWSLGCIAYESMA 195
            :||.|....||||||.||.|:..|.||||||||||||:|||:.|:||||.||:||:|||.||...
  Rat   131 ILLAKGGGIKLCDFGFARAMSTNTMVLTSIKGTPLYMSPELVEERPYDHTADLWSVGCILYELAV 195

  Fly   196 GQPPFCASSILHLVKMIKHEDVKWPSTLTSECRSFLQGLLEKDPGLRISWTQLLCHPFVEGRIFI 260
            |.|||..:||..||.:|..:.|:||||:||..::||||||.|||..|:||..||.|||:.||:.|
  Rat   196 GTPPFYTTSIFQLVSLILKDPVRWPSTITSCFKNFLQGLLTKDPRQRLSWPDLLHHPFIAGRVTI 260

  Fly   261 AETQAEAAKESPFTN---PEAKVKSSKQSD---PEVGDLDEAL------AALDFGESRQENLTTS 313
            ....|.:...:|||:   ||.:|...:|:.   |: |:....|      .|.:..:...:|..::
  Rat   261 ITEPAGSNLGTPFTSRLPPELQVLKDEQAHRLAPK-GNQSRILRQACKRMAEEAKQKEDQNTGST 324

  Fly   314 RDS---INAIAPSDVEHLETDVEDNMQRVVVPFADLSYRDLSGVRAMPMVHQPVINSHTCFVSGN 375
            .|.   ::.:.||...              ||          |::|.|        ..:..::|
  Rat   325 LDQEARLSKVTPSTAP--------------VP----------GLKATP--------QESSLLAG- 356

  Fly   376 SNMILNHMNDNFDFQASLRGGGVAAKPIVAPTVRQSRSKDLEKRKLSQNLDNFSVRLGHSVDHEA 440
              ::.:.|.:|::..    |.|.|     .||.|::.                       :..|.
  Rat   357 --LLASEMKNNWEDW----GAGEA-----PPTPRENH-----------------------ITLEC 387

  Fly   441 QRKATEIATQEKHNQENKPPAEAISYANSQPPQQQP-QQLKHSMHSTNEEKLSSDNTPPCLLPGW 504
            ::...|:..:..    .:...:|:...|.:|..... |:|..:|.....:..|    |..||...
  Rat   388 EQAFPELRPETM----GRRSTDAVDPENEEPDSDDEWQRLLETMEPVPVQLKS----PLTLLCNP 444

  Fly   505 DSCDESQSPPIENDEWLAFLNRSVQELLDGELDSLKQHNLVSI-IVAPLRNSKAIPRVLKSVAQL 568
            |.|...||.          |..:.:::|.|.||. ..|.|.:: |::.|.:|.:...:|.|..|.
  Rat   445 DFCQHIQSQ----------LRGTGEQILKGVLDG-ASHLLPALRILSSLLSSCSDSVLLYSFCQE 498

  Fly   569 LSLPFVLVDPVLIVDLELIR--------------NVYV-DVKLVPNLMYACKLLLSHKQLSDS-- 616
            :.||        .:.|.|:|              ..:: ::..|....::|...|...|..||
  Rat   499 VGLP--------ELPLSLLRYSQESSSIQQQPWYGAFLRELVAVVQAYFSCTFNLERSQTGDSLQ 555

  Fly   617 --AASAPLTTGSLSRTLRSIPELTVEELETACSLYELVCHLVHLQQQFLTQFCDAV--------- 670
              ..:|.|....|.:.|..     .::.|.......|:|..|         .|:||
  Rat   556 VFEEAASLFLDLLGKLLAQ-----PDDSEPTFRRDSLMCFAV---------LCEAVDGNSRAISK 606

  Fly   671 ----AILAASDLFLNFLTH--------------------DFRQSDSD---AASVRLAGCMLALMG 708
                ::|......|:.|.|                    ..|:...|   |.|..||....|.:|
  Rat   607 AFYASLLTTQRAVLDGLLHGLTVPQLPFHTPPGAPQVSQPLREQSEDVPGAISSALAAMCTAPVG 671

  Fly   709 CVLRELPENAELVERIVFN-----------PRLNFVSLLQSRHHLL--------------RQRSC 748
                 ||...:..|::.::           .|.:.:|.|  |||:|              .:|.|
  Rat   672 -----LPSCWDAKEQVSWHLANQLTEDSSQLRPSLISGL--RHHILCLHLLKVLYSCCYISERLC 729

  Fly   749 QLL--RLLARFSL----RGVQRI--WNGELRFALQQLS 778
            .:|  ..||..||    :|..::  |......||..||
  Rat   730 HILGQEPLALESLLMLVQGKVKVADWEESTEVALYLLS 767

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fu	NP_477499.1	STKc_STK36	2..254	CDD:270904	138/251 (55%)
fu	NP_477499.1	Pkinase	4..254	CDD:278497	138/249 (55%)
Stk36	XP_006245236.1	STKc_STK36	2..254	CDD:270904	138/251 (55%)
Stk36	XP_006245236.1	S_TKc	4..254	CDD:214567	138/249 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166343730
Domainoid	1	1.000	286	1.000	Domainoid score	I1537
eggNOG	1	0.900	-	-		E1_KOG0597
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005852
OrthoInspector	1	1.000	-	-		oto98028
orthoMCL	1	0.900	-	-		OOG6_103862
Panther	1	1.100	-	-	LDO	PTHR22983
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X5605
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.740