DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fu and Stk36

DIOPT Version :9

Sequence 1:	NP_477499.1	Gene:	fu / 32855	FlyBaseID:	FBgn0001079	Length:	805	Species:	Drosophila melanogaster
Sequence 2:	NP_778196.2	Gene:	Stk36 / 269209	MGIID:	1920831	Length:	1316	Species:	Mus musculus

Alignment Length:	877	Identity:	264/877 - (30%)
Similarity:	389/877 - (44%)	Gaps:	209/877 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MNRYAVSSMVGQGSFGCVYKATRKDDSKVVAIKVISKRGRATKELKNLRRECDIQARLKHPHVIE 65
            |.:|.|..|:|:||||.|||..:|..::|||:|.|.|.||:.|||:||:||.:|...|.||:::.
Mouse     1 MEKYHVLEMIGEGSFGRVYKGRKKYSAQVVALKFIPKLGRSEKELRNLQREIEIMRGLWHPNIVH 65

  Fly    66 MIESFESKTDLFVVTEFALMDLHRYLSYNGAMGEEPARRVTGHLVSALYYLHSNRILHRDLKPQN 130
            |::|||:..::.|||::|..:|.:.|..:|.:.|:..:.:...||||||||||:||||||:||||
Mouse    66 MLDSFETDKEVVVVTDYAEGELFQILEDDGKLPEDQVQAIAAQLVSALYYLHSHRILHRDMKPQN 130

  Fly   131 VLLDKNMHAKLCDFGLARNMTLGTHVLTSIKGTPLYMAPELLAEQPYDHHADMWSLGCIAYESMA 195
            :||.|....||||||.||.|:..|.||||||||||||:|||:.|:||||.||:||:|||.||...
Mouse   131 ILLAKGGGIKLCDFGFARAMSTNTMVLTSIKGTPLYMSPELVEERPYDHTADLWSVGCILYELAV 195

  Fly   196 GQPPFCASSILHLVKMIKHEDVKWPSTLTSECRSFLQGLLEKDPGLRISWTQLLCHPFVEGRIFI 260
            |.|||..:||..||.:|..:.|:||||::|..::||||||.|||..|:||..||.|||:.||:.|
Mouse   196 GTPPFYTTSIFQLVSLILKDPVRWPSTISSCFKNFLQGLLTKDPRQRLSWPDLLHHPFIAGRVTI 260

  Fly   261 AETQAEAAKESPFTN---PEAKVKSSKQSD---PEVGDLDEAL---AALDFGESRQENLTTSRDS 316
            ....|.:...:|||:   ||.:|...:|:.   |: |:....|   ..|...|::|:.
Mouse   261 ITEPAGSDLGTPFTSRLPPELQVLKDEQAHRLAPK-GNQSRILRQACKLMAEEAKQKE------- 317

  Fly   317 INAIAPSDVEHLETDVEDNMQRVVVPFADLSYRDLSGVRAMPMVHQPVINSHTCFVSGNSNMILN 381
             :..|.|.:|.     ||.:.:|..     |...:.|::|.|        ..:..::|   ::.:
Mouse   318 -DQNAGSALEQ-----EDGLCKVTP-----STAPVPGLKATP--------QESSLLAG---ILAS 360

  Fly   382 HMNDNFDFQASLRGGGVAAKPIVAPTVRQSRSKDLEKRKLSQNLDNFSVRLGHSVDH-EAQ-RKA 444
            .|.:|::      ..|....|      |.||          :|..|.....|..... ||. |::
Mouse   361 EMKNNWE------DWGAGEAP------RTSR----------ENHINLECEQGFPEPRPEAMGRQS 403

  Fly   445 TEIATQEKHNQENKPPAEAISYANSQPPQQQPQQLKHSMHSTNEEKLSSDNTPPCLLPGWDSCDE 509
            |::...|....::....:.: ...|:|   .|.|||               :|..||...|.|..
Mouse   404 TDVVDPENEEPDSDDEWQRL-LETSEP---GPVQLK---------------SPLTLLCNPDFCQR 449

  Fly   510 SQSPPIENDEWLAFLNRSVQELLDGELDSLKQHNLVSIIVAPLRNSKAIPRVLKSVAQLLSLPFV 574
            .||.          |..:.:::|.|.||.:.....|..|::.|.:|.....:|.|..|...||
Mouse   450 IQSQ----------LRGTGEQILKGVLDGVSHLLPVLRILSSLLSSCNDSVLLYSFCQEAGLP-- 502

  Fly   575 LVDPVLIVDLELIR---------------NVYVDVKLVPNLMYACKLLLSHKQLSDS----AASA 620
                  .:.|.|:|               .:..|:..|....::|...|...|..||    ..:|
Mouse   503 ------ELPLSLLRYSQESSSIQQQPWYGALLRDLVAVVQAYFSCTFNLERSQTGDSLQVFQEAA 561

  Fly   621 PLTTGSLSRTLRSIPELTVEELETACSLYELVCHLVHLQQQFLTQFCDAV-------------AI 672
            .|....|.:.|..     .::.|.......|:|..|         .|:||             ::
Mouse   562 SLFLDLLGKLLAQ-----SDDSEQTFRRDSLMCFAV---------LCEAVDGNSWAVSKAFYSSL 612

  Fly   673 LAASDLFLNFLTH--------------------DFRQSDSD---AASVRLAGCMLALMGCVLREL 714
            |......|:.|.|                    ..|:...|   |.|..||....|.:|     |
Mouse   613 LTTQRAVLDGLLHGLTVPQLPFHTPPGAPQVSQPLREQSEDVPGAISSALAAMCTAPVG-----L 672

  Fly   715 PENAELVERIVFN-----------PRLNFVSLLQSRHHLL--------------RQRSCQLL--R 752
            |...:..|::.::           .|.:.:|.|  |||:|              .:|.|.:|  .
Mouse   673 PSCWDAKEQVSWHLANQLTEDSSQLRPSLISGL--RHHVLCLHLLKVLYACCYISERLCHILGQE 735

  Fly   753 LLARFSL----RGVQRI--WNGELRFALQQLS 778
            .||..||    :|..::  |......||..||
Mouse   736 PLALESLLMLVQGKVKVADWEESTEVALYLLS 767

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fu	NP_477499.1	STKc_STK36	2..254	CDD:270904	136/251 (54%)
fu	NP_477499.1	Pkinase	4..254	CDD:278497	136/249 (55%)
Stk36	NP_778196.2	STKc_STK36	2..254	CDD:270904	136/251 (54%)
		S_TKc	4..254	CDD:214567	136/249 (55%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	389..418		6/28 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167839888
Domainoid	1	1.000	283	1.000	Domainoid score	I1637
eggNOG	1	0.900	-	-		E1_KOG0597
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4033
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005852
OrthoInspector	1	1.000	-	-		oto94516
orthoMCL	1	0.900	-	-		OOG6_103862
Panther	1	1.100	-	-	LDO	PTHR22983
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6666
SonicParanoid	1	1.000	-	-		X5605
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	10.720