DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6659 and Dpy19l4

DIOPT Version :9

Sequence 1:	NP_573317.1	Gene:	CG6659 / 32854	FlyBaseID:	FBgn0030946	Length:	872	Species:	Drosophila melanogaster
Sequence 2:	NP_001074670.1	Gene:	Dpy19l4 / 381510	MGIID:	2685869	Length:	722	Species:	Mus musculus

Alignment Length:	901	Identity:	172/901 - (19%)
Similarity:	309/901 - (34%)	Gaps:	299/901 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 LIGC---------GFFFLYVQHVRVI-FETRTNIQQLNQLEREALLRREDALYYAFYKQLAEGPD 68
            :|||         ..|:|...|.|.. |..|      .:||||...:.:.|:||::||.:.:.|.
Mouse    52 VIGCLAAVISGMMHVFYLSAYHERKFWFSNR------QELEREITFQGDSAIYYSYYKDMLKAPS 110

  Fly    69 FWHG-YEQLKNVTDIEYPHSVNVLQRFYVLPELVTAYFFHVVRSGFNPMVQPMQFYLEFVWLMGG 132
            |..| ||...|...|.. .::|.:|:..:.|||:.:..:..  :|.|.:::|:.||:..|:.:.|
Mouse   111 FERGVYELTHNNKTISL-KTINAMQQMSLYPELIASVLYQA--TGSNEVIEPVYFYIGIVFGLQG 172

  Fly   133 VTLLVLYLYGTLLSENIFGGIYGVISYLMFHSFVAKI-YERPLARENFAFPFIFLQMFYLCICIG 196
            :.:..|::...|:|.....|:..|..:|:......:| |..|| |||:|.|:...|:..|   .|
Mouse   173 MYVTALFVTSWLMSGTWLAGMLTVAWFLINRVDTTRIEYSIPL-RENWALPYFACQVAAL---TG 233

  Fly   197 RIIHRQRHTSRMFMIFAMSLFTACALLSWQFSTFIFTTQILIMMTSWNASALPTALVNAFVLD-- 259
            .:.......:..|....:|..|...::.|::|.::...|           |:...|::.|.::
Mouse   234 YLKRNLNTYAERFCYLLLSTSTYTFMMVWEYSHYVLFLQ-----------AVSLLLLDIFSVEQS 287

  Fly   260 ---------YSLSHLLGHALAFVMSHGNSQLLLTWQLSISLFLFLITMVRQLRHVRSRRLGHAQD 315
                     |..|..||:.|.|    .|..||::..||: :..|::....||...:...:  |:.
Mouse   288 DKVYEVYKVYIFSLFLGYLLQF----ENPALLVSPLLSL-VGAFMLVKCLQLNGKKGTFV--AKV 345

  Fly   316 LLNGDLFSLKFLMLTLLLASSVQTTLIELFNRAGVVSVTEGDQQH---FFDICAHWALQVNVGFV 377
            :...:.:.|..|.:||.|       ::::|       |...:.:|   |.::  .:.|.:...|.
Mouse   346 IKVFEFYLLCTLPVTLNL-------IVKMF-------VPHKENEHVLKFLEV--KFGLNMTKNFT 394

  Fly   378 AHLSACNPQYARVAWSELWQLVKTMIVKPYCMYGVV----MLAMFFRRWRKSGAPVSALTEEQRE 438
            .:...|.......:....::|.::.::..|.:..::    |..:||||
Mouse   395 LNWLLCQESLQAPSQDFFFRLTQSSLLPFYVLVLIICLLSMTQVFFRR----------------- 442

  Fly   439 RARKYVLEDFIEEHFVSMSDMSSKETEKQLYKCFRLLKSCDYDYERYKRAQASLRKEQPPARDDF 503
                             ||..|.|||
Mouse   443 -----------------MSGKSKKET--------------------------------------- 451

  Fly   504 MQDIKRLRAQINRNSVKQRKERAQETKEAATDGASTPTEEEDKDPEAESESKKKNQEPGSGETET 568
                    ..:....:.:|.|
Mouse   452 --------VTLEDGRIGERPE-------------------------------------------- 464

  Fly   569 ESAADPTETPPSRSADNEEEEEEHSATAAGCGSNSSGHRQRKRSSSRRSSVVPTANAQILNMHYV 633
                                                                           .:
Mouse   465 ---------------------------------------------------------------II 466

  Fly   634 YSFLQMLVFTLIGLAVRKLFFLSFTQGCVIAP-TVCS-KLW-----YHRQRNIFWSVSLAVFLLS 691
            |..:..|:...:.:.:..|.|:.....|::|. .||| :||     :.|.|.:  ...|...:||
Mouse   467 YHVIHTLLLGSLAMLMEGLKFIWTPYVCMLAAFGVCSPELWMTLLKWLRLRTV--HPMLLALILS 529

  Fly   692 MFDPGMVNIR--EEYFP------TRYSKSGD-DLDSMLEWIKLNTERDAVFAGPVDIIGTVHLTT 747
            |..|.::.:.  :|:||      |...:..| |...::.|||......|||||...::|.:.|.|
Mouse   530 MAVPTIIGLSLWKEFFPRLITELTELQEFYDPDTVELMTWIKRQAPVAAVFAGSPQLMGVIKLCT 594

  Fly   748 KRPIVNHAHLEMRQIAERTEHVYSVYSRQQSSDIYNQCAQLKIQYLIISLDECTNE--------V 804
            ...:.:........:.:|.|::|.:||::.:.|||......|..|||:. |...||        |
Mouse   595 GWTVTSLPLYSDDDLLQRNENIYQIYSKRSAEDIYKILTSYKANYLIVE-DAICNELGTTRGCRV 658

  Fly   805 RDDCDL----LAIWDDKQPAYQKYPQFCHELLHKNVP---SFLKVFANDHYGIIKM 853
            :|..|:    :...:..:..|.||.:||||:.....|   .|.:|:.|..|.:.|:
Mouse   659 KDLLDIANGHVVFEEGDKLTYSKYGRFCHEVKINYSPYVNYFTRVYWNRSYFVYKV 714

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6659	NP_573317.1	Dpy19	18..852	CDD:287052	168/885 (19%)
CG6659	NP_573317.1	Neuromodulin	521..>599	CDD:284117	2/77 (3%)
Dpy19l4	NP_001074670.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..34
Dpy19l4	NP_001074670.1	Dpy19	60..713	CDD:287052	168/890 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167834989
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4587
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm44054
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	5	4.700