Protein Alignment CG6659 and dpy19l1l

DIOPT Version :10

• Sequence 1: NP_573317.1
• Gene: CG6659 / 32854
• FlyBaseID: FBgn0030946
• Length: 872
• Species: Drosophila melanogaster
• Sequence 2: NP_001002868.1
• Gene: dpy19l1l / 368327
• ZFINID: ZDB-GENE-030521-11
• Length: 730
• Species: Danio rerio
• Alignment Length: 897
• Identity: 199/897 - (22%)
• Similarity: 348/897 - (38%)
• Gaps: 278/897 - (30%)

  Fly     4 PNLYV----ILSHALIGCGFFFLYVQHVRVIFETRTNIQQLNQLEREALLRREDALYYAFYKQLA 64
            |:.:|    :|..|:: .|||..|  |:..:||...:...::.||:|...|.|..|||:::|.:.
Zfish    57 PSAFVRGITVLILAVV-AGFFHWY--HLSHLFENDRHFSHMSTLEKEMAFRTEMGLYYSYFKTII 118

  Fly    65 EGPDFWHGYEQLKNVTDIEYPHSVNVLQRFYVLPELVTAYFFHVVRS------------------ 111
            |.|.|..|...:.|....|||..:|.|:||.:.||:|.|.::....|
Zfish   119 EAPSFMDGLYMIMNDRLTEYPLVINTLKRFNLYPEVVLASWYRAYSSTMNFFGFPTKLCWTINRG 183

  Fly   112 -GFNP------MVQPMQFYLEFVWLMGGVTLLVLYLYGTLLSENIFGGIYGVISYLMFHSFVAKI 169
             |.:|      :..|..||:.||:|:.|..:.:.::|||.||.:..||...|:.:...|....::
Zfish   184 EGLDPVESCEGLGDPAYFYVAFVFLLNGAMMSLFFIYGTYLSGSRLGGTVTVLCFFFNHGESTRV 248

  Fly   170 YERPLARENFAFPFIFLQMFYLCICIGRIIHRQRHTSRMFMIFAMSLFTACALLSWQFSTFIFTT 234
            ...|..||:|::||:.|||..|     ..|.|.::.|:..|: |:.:.....:|.|||:.|:..|
Zfish   249 MWTPPLRESFSYPFLVLQMLLL-----TYILRTKNPSKNTMM-ALGISNVFFMLPWQFAQFVLLT 307

  Fly   235 QILIMMTSWNASALPTALVNAFVLDYSLSHLLGHALAFVMSHGNSQLLLTWQLSISLFLFLITMV 299
            |:..:..|:....|..|.:.:.:    ::|::..|:.|::..|||.||.::..|..:.::.:..:
Zfish   308 QVASLFASYILGYLSPAKMQSIL----VTHMVSLAVCFLLMFGNSMLLTSFYASSLVSIWGVIAL 368

  Fly   300 RQLRHVRSRRLGHAQDLLNGDLFSLKFLMLTLLLASSVQTTLIELFNRAGVVSVTEGDQQHFFDI 364
            |              |.|.|..                         |.|:::
Zfish   369 R--------------DRLVGTF-------------------------RPGLIT------------ 382

  Fly   365 CAHWALQVNVGFVAHLSACNPQYARVAWSELWQLVKTMIVKPYCMYGVVMLAMFFRRWRKSGAPV 429
               |..|           |      .||     :|.|:|:|       .||::.|  .....|.:
Zfish   383 ---WVTQ-----------C------FAW-----VVSTVILK-------FMLSVIF--GASDDAHI 413

  Fly   430 SALTEEQRERARKYVLEDFIEEHFVSMSDMSSKETEKQLYKCFRLLKSCDYDYERYKRAQASLRK 494
            |:|                |:..|.|..|.     :..:|.|     :.::|:         :..
Zfish   414 SSL----------------IKSKFTSYKDF-----DTMMYTC-----AAEFDF---------IEA 443

  Fly   495 EQPPARDDFMQDIKRLRAQINRNSVKQRKERAQETKEAATDGASTPTEEEDKDPEAESESKKKNQ 559
            :.|      ::.||.:...||...|            |...|...    :|......:|.::|::
Zfish   444 DTP------IRYIKTMLLPINVLIV------------AFIAGRII----QDVIVFLRNEKQEKSE 486

  Fly   560 EPGSGETETESAADPTETPPSRSADNEEEEEEHSATAAGCGSNSSGHRQRKRSSSRRSSVVPTAN 624
            :                         :|.|:.| ..|.|.
Zfish   487 D-------------------------DETEQSH-LLAKGV------------------------- 500

  Fly   625 AQILNMHYVYSFLQMLVFTLIGLAVRKLFFLSFTQGCVIAPTVCSKLWYHRQRNIF-W------- 681
                   .||..||::.|.::.:.:.:|........|:::..:||       |.:| |
Zfish   501 -------LVYHSLQLVAFAVLAVLIMRLKLFLTPHMCIMSCLICS-------RQLFGWIGEKLKL 551

  Fly   682 SVSLAVFLLSMFDPGMVNIREEY--------FPTRYSKSGDDLDSMLEWIKLNTERDAVFAGPVD 738
            .:::...|..|...|:||::.::        :|.         :.:|||||.:|...|||||.:.
Zfish   552 QMTVVGILCIMAAQGVVNLQSQWSIIGEFSNYPQ---------EELLEWIKDSTSPTAVFAGAMP 607

  Fly   739 IIGTVHLTTKRPIVNHAHLEMRQIAERTEHVYSVYSRQQSSDIYNQCAQLKIQYLIISLDECTNE 803
            .:.:|.|:|.|.||||.|.|...:..||:.||::|||:.:.::.....:|:..|.|:....||..
Zfish   608 TMASVKLSTGRAIVNHPHYEDAGLRARTKMVYAMYSRKPAEEVKRNLIKLQADYFILEDSWCTRR 672

  Fly   804 VRDDCDLLAIWD--DKQPAYQKYPQFCHELLHKNVPSFLKVFANDHYGIIKM 853
            .:..|.:..|||  |.:.| .|.| .|..:...:.|.|..||.|:.|.::::
Zfish   673 SKPGCSMPEIWDVEDAENA-GKVP-LCTLMSRDSRPHFSTVFHNNIYKVLRV 722

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG6659	NP_573317.1	Dpy19	17..853	CDD:462945	195/878 (22%)
dpy19l1l	NP_001002868.1	Dpy19	62..720	CDD:455131	197/888 (22%)
		putative TM segment 1	62..78	CDD:439130	5/16 (31%)
		putative TM segment 2	198..219	CDD:439130	7/20 (35%)
		putative TM segment 3	223..239	CDD:439130	5/15 (33%)
		putative TM segment 4	259..273	CDD:439130	6/18 (33%)
		putative TM segment 5	282..297	CDD:439130	2/15 (13%)
		putative TM segment 6	303..321	CDD:439130	4/17 (24%)
		putative TM segment 7	329..346	CDD:439130	3/20 (15%)
		putative TM segment 8	349..365	CDD:439130	3/15 (20%)
		putative TM segment 9	383..401	CDD:439130	9/46 (20%)
		putative TM segment 10	453..474	CDD:439130	6/36 (17%)
		putative TM segment 11	505..521	CDD:439130	3/15 (20%)
		putative TM segment 12	525..547	CDD:439130	6/28 (21%)
		putative TM segment 13	551..566	CDD:439130	2/14 (14%)