DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6659 and Dpy19l2

DIOPT Version :9

Sequence 1:	NP_573317.1	Gene:	CG6659 / 32854	FlyBaseID:	FBgn0030946	Length:	872	Species:	Drosophila melanogaster
Sequence 2:	NP_001159679.1	Gene:	Dpy19l2 / 320752	MGIID:	2444662	Length:	773	Species:	Mus musculus

Alignment Length:	931	Identity:	195/931 - (20%)
Similarity:	329/931 - (35%)	Gaps:	341/931 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LYVILSH----------------ALIGCGFF--FLYVQHVRVIFETRTNIQQLNQLEREALLRRE 52
            |:.:|.|                .|.|...|  .|:..|:..:||...:...|:.||||...|.|
Mouse   100 LFTLLDHFREKVQALQMHRFSHRTLFGLAIFVGILHWLHLITLFENDHHFSHLSSLEREMTFRTE 164

  Fly    53 DALYYAFYKQLAEGPDFWHGYEQLKNVTDIEYPHSVNVLQRFYVLPELVTAYFFHVVRSGFN--- 114
            ..|||:::|.:.|.|.|..|...:.|....|||..:|.::||::.||:|.||::..:....|
Mouse   165 MGLYYSYFKTIIEAPSFLEGLWMIMNDRLTEYPLVINTVKRFHLYPEVVIAYWYRTIIGIMNLFG 229

  Fly   115 -------------PM--VQ-------PMQFYLEFVWLMGGVTLLVLYLYGTLLSENIFGGIYGVI 157
                         |:  ||       |..||:..::::.|:.:.:.::|.|.||.:..||:..|.
Mouse   230 IETKTCWNVTRMEPLNEVQSCEGLGDPACFYIGVIFILNGLMMGLFFIYSTYLSGSQLGGLITVA 294

  Fly   158 SYLMFHSFVAKIYERPLARENFAFPFIFLQMFYLCICI-GRIIHRQRHTSRMFMIFAMSLFTACA 221
            .|...|....::...|..||:|::||:.|||:.|.|.: ...:|::.:   |.:.|:...|
Mouse   295 CYFFNHGEATRVMWTPPLRESFSYPFLVLQMYILTIILRTSTVHKKHY---MALCFSNVAF---- 352

  Fly   222 LLSWQFSTFIFTTQILIMMTSWNASALPTALVNAF-------VLDYSLSHLLGHALAFVMSHGNS 279
            :|.|||:.||..|||        ||..|..:|...       ::..::|.:   ||.|::..|||
Mouse   353 MLPWQFAQFILFTQI--------ASLFPMYVVGYIEPSKFQKIIYVNMSSV---ALCFILMFGNS 406

  Fly   280 QLLLTWQLSISLFLFLITMVRQLRHVRSRRLGHAQDLLNGDLFSLKFLMLTLLLASSVQTTLIEL 344
            ..|.::..|    ..|:|.....:..:.::||
Mouse   407 MYLSSYYSS----CLLVTWAIMQKKSKIQKLG--------------------------------- 434

  Fly   345 FNRAGVVSVTEGDQQHFFDICAHWALQVNVGFVAHLSACNPQYARVAWSELWQLVKTMIVKPYCM 409
                       |.:..|      |.:|          .|           .|          :|
Mouse   435 -----------GTELQF------WLIQ----------GC-----------FW----------WC- 450

  Fly   410 YGVVMLAMFFRRWRKSGAPVSALTEEQRERARKYVLEDF--IEEHFVSMSDMSSKETEKQLYKCF 472
             |.::|                          |::....  :.:| :.:||:.:.
Mouse   451 -GTIIL--------------------------KFLTSKICGVSDH-IRLSDLIAA---------- 477

  Fly   473 RLLKSCDYDYERYKRAQASLRKEQPPARDDFMQDIKRLR------------------AQINRNSV 519
            |:|:..|:|...|..|          ...|||:....||                  .:|.|:.:
Mouse   478 RILRYTDFDTLIYTCA----------PEFDFMEQATPLRYIKTLLLPLILVITYLIFKKIVRDIM 532

  Fly   520 KQRKERAQETKEAATDGASTPTEEEDKDPEAESESKKKNQEPGSGETETESAADPTETPPSRSAD 584

Mouse   533 ----------------------------------------------------------------- 532

  Fly   585 NEEEEEEHSATAAGCGSNSSGHRQRKRSSSRRSSVVPTANAQIL-NMHYVYSFLQMLVFTLIGLA 648
                          |...::.:.::                |:| |...::..||:|.||.:.:.
Mouse   533 --------------CVLYTNTYVRK----------------QLLDNAELIFHTLQLLAFTGLAIL 567

  Fly   649 VRKLFFLSFTQGCVIAPTVCSKLWYHRQRNIFWSVSLAVF------LLSMFD-PGMVNIREEYFP 706
            :.:|........|::|..:||      ||...|......|      :|:|.. .|..|:..:
Mouse   568 IMRLKLFLTPHMCIMASLICS------QRLFGWLFCRIHFENVVFGILTMMSIQGCANLHNQ--- 623

  Fly   707 TRYSKSGD----DLDSMLEWIKLNTERDAVFAGPVDIIGTVHLTTKRPIVNHAHLEMRQIAERTE 767
              :|..|:    ..:.::.|||.:|..||||||.:..:.::.|:|.||||||.|.|...:..||:
Mouse   624 --WSIMGEFTNLPQEELIHWIKHSTRPDAVFAGAMPTMASIKLSTLRPIVNHPHYEDADLRARTK 686

  Fly   768 HVYSVYSRQQSSDIYNQCAQLKIQYLIISLDECTNEVRDDCDLLAIWDDKQPAYQKYPQFCHELL 832
            .|||||||:.:.::.|...:|.:.|.::....|....:..|.:|.|||.:.|:....|..|..||
Mouse   687 IVYSVYSRKSAVEVRNNLLKLHVNYYVLEEAWCVVRTKPGCSMLEIWDVEDPSNAANPPLCSILL 751

  Fly   833 HKNVPSFLKVFANDHYGIIKM 853
            ..:.|.|..||.|..|.::|:
Mouse   752 KDSRPYFTTVFQNSMYRVLKI 772

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6659	NP_573317.1	Dpy19	18..852	CDD:287052	189/900 (21%)
CG6659	NP_573317.1	Neuromodulin	521..>599	CDD:284117	0/77 (0%)
Dpy19l2	NP_001159679.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..45
Dpy19l2	NP_001159679.1	Dpy19	130..771	CDD:287052	189/898 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	240	1.000	Domainoid score	I2251
eggNOG	1	0.900	-	-		E1_KOG4587
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	241	1.000	Inparanoid score	I3324
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG47962
OrthoDB	1	1.010	-	-		D1115173at2759
OrthoFinder	1	1.000	-	-		FOG0004434
OrthoInspector	1	1.000	-	-		otm44054
orthoMCL	1	0.900	-	-		OOG6_107418
Panther	1	1.100	-	-	O	PTHR31488
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	10.880