DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6659 and Dpy19l1

DIOPT Version :9

Sequence 1:	NP_573317.1	Gene:	CG6659 / 32854	FlyBaseID:	FBgn0030946	Length:	872	Species:	Drosophila melanogaster
Sequence 2:	NP_001178720.1	Gene:	Dpy19l1 / 315496	RGDID:	1305822	Length:	746	Species:	Rattus norvegicus

Alignment Length:	891	Identity:	187/891 - (20%)
Similarity:	325/891 - (36%)	Gaps:	304/891 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 LYVQHVRVIFETRTNIQQLNQLEREALLRREDALYYAFYKQLAEGPDFWHGYEQLKNVTDIEYPH 86
            |:..|:..:||...:...|:.||||...|.|..|||:::|.:.|.|.|..|...:.|....|||.
  Rat   104 LHWSHITQLFENDRHFSHLSTLEREMAFRTEMGLYYSYFKTIVEAPSFLSGVWMIMNDRLTEYPL 168

  Fly    87 SVNVLQRFYVLPELVTAYFFHVVR-------------------SGFNP------MVQPMQFYLEF 126
            .:|.|:||.:.||::.|.::.:..                   .|.:|      :..|..||:..
  Rat   169 VINTLKRFNLYPEVILASWYRIYTKIMDLIGIQTKICWTVTRGEGLSPIESCEGLGDPACFYVAV 233

  Fly   127 VWLMGGVTLLVLYLYGTLLSENIFGGIYGVISYLMFHSFVAKIYERPLARENFAFPFIFLQMFYL 191
            ::::.|:.:.:.::|||.||.:..||:..|:.:...|....::...|..||:|::||:.|||..:
  Rat   234 IFMLNGLMMALFFIYGTYLSGSRLGGLVTVLCFFFNHGECTRVMWTPPLRESFSYPFLVLQMLLV 298

  Fly   192 CICIGRIIHRQRHTSRMFMIFAMSLFTACA-----LLSWQFSTFIFTTQILIMMTSWNASALPTA 251
                       .|..|...::..||...|.     :|.|||:.|:..|||         ::|...
  Rat   299 -----------THILRTTQLYRGSLIALCISNVFFMLPWQFAQFVLLTQI---------ASLFAV 343

  Fly   252 LVNAFVLDYSL-----SHLLGHALAFVMSHGNSQLLLTWQLSISLFLFLITMVRQLRHVRSRRLG 311
            .|..::..|.|     :|::...|.||:..|||.||.::..| ||.:.
  Rat   344 YVVGYIDTYKLQKIIYTHMISLVLCFVLMFGNSMLLTSYYAS-SLVII----------------- 390

  Fly   312 HAQDLLNGDLFSLKFLMLTLLLASSVQTTLIELFNRAGVVSVTEGDQQHFFDICAHWALQVNVGF 376
                                                                    |.
  Rat   391 --------------------------------------------------------WG------- 392

  Fly   377 VAHLSACNPQYARVAWSE--LWQLVKTMIVKPYC-MYGVVMLAMFFRRWRKSGAPVSALTEEQRE 438
               :.|..||:.::..||  ||      :::..| ::|.|.|              .:||
  Rat   393 ---MLAMKPQFLKMNVSELSLW------VIQGCCWLFGTVTL--------------KSLT----- 429

  Fly   439 RARKYVLEDFIEEH---FVSMSDMSSKETEKQLYKCFRLLKSCDYDYERYKRAQASLRKEQP--P 498
             :|.:.:.|  :.|   .::....|.|:.:..||.|     :.::|:         :.||.|  .
  Rat   430 -SRIFGIAD--DAHIGNLLTSKFFSYKDFDTLLYTC-----AAEFDF---------MEKETPLRY 477

  Fly   499 ARDDFMQDIKRLRAQINRNSVKQRKERAQETKEAATDGASTPTEEEDKDPEAESESKKKNQEPGS 563
            .:...:..:..:.|.|.|..:...:
  Rat   478 TKTLLLPVVLAIVAAIGRKIINDMR---------------------------------------- 502

  Fly   564 GETETESAADPTETPPSRSADNEEEEEEHSATAAGCGSNSSGHRQRKRSSSRRSSVVPTANAQIL 628
                            ...|:.|.:..:|                                 |:.
  Rat   503 ----------------GVIANQETDVRKH---------------------------------QVD 518

  Fly   629 NMHYVYSFLQMLVFTLIGLAVRKLFFLSFTQGCVIAPTVCSKLWYHRQRNIF-W--------SVS 684
            :...||..||:..:|.:|:.:.:|........||:|..:||       |.:| |        :|.
  Rat   519 HGELVYHALQLFAYTALGILIMRLKLFLTPHMCVMASLICS-------RQLFGWLFGKVHPGAVV 576

  Fly   685 LAVFLLSMFDPGMVNIREEYFPTRYSKSGD----DLDSMLEWIKLNTERDAVFAGPVDIIGTVHL 745
            .|| |.:|...|..|::     |:::..|:    ..:.::|||:.:|:.||||||.:..:.:|.|
  Rat   577 FAV-LAAMSIQGSANLQ-----TQWNIVGEFSNLPQEELIEWIRHSTKPDAVFAGAMPTMASVKL 635

  Fly   746 TTKRPIVNHAHLEMRQIAERTEHVYSVYSRQQSSDIYNQCAQLKIQYLIISLDECTNEVRDDCDL 810
            :..||:|||.|.|...:..||:.|||:|||:...|:..:..:||:.|.|:....|....:..|.:
  Rat   636 SALRPVVNHPHYEDAGLRARTKIVYSMYSRKAPEDVKKELIKLKVNYYILEESWCIRRSKPGCSM 700

  Fly   811 LAIWDDKQPAYQKYPQFCHELLHKNVPSFLKVFANDHYGIIKMFSQ 856
            ..|||.:.|........|:.|:..:.|.|..||.|..|.::::..|
  Rat   701 PEIWDVEDPDNAGKTPLCNILVKDSKPHFTTVFQNSVYKVLEVIRQ 746

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6659	NP_573317.1	Dpy19	18..852	CDD:287052	186/885 (21%)
CG6659	NP_573317.1	Neuromodulin	521..>599	CDD:284117	3/77 (4%)
Dpy19l1	NP_001178720.1	Dpy19	105..743	CDD:401862	185/885 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	238	1.000	Domainoid score	I2226
eggNOG	1	0.900	-	-		E1_KOG4587
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	240	1.000	Inparanoid score	I3261
OMA	1	1.010	-	-		QHG47962
OrthoDB	1	1.010	-	-		D1115173at2759
OrthoFinder	1	1.000	-	-		FOG0004434
OrthoInspector	1	1.000	-	-		otm46143
orthoMCL	1	0.900	-	-		OOG6_107418
Panther	1	1.100	-	-	LDO	PTHR31488
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.880