Protein Alignment CG6659 and Dpy19l3

DIOPT Version :9

• Sequence 1: NP_573317.1
• Gene: CG6659 / 32854
• FlyBaseID: FBgn0030946
• Length: 872
• Species: Drosophila melanogaster
• Sequence 2: NP_001129307.2
• Gene: Dpy19l3 / 308519
• RGDID: 1308334
• Length: 717
• Species: Rattus norvegicus
• Alignment Length: 895
• Identity: 180/895 - (20%)
• Similarity: 323/895 - (36%)
• Gaps: 276/895 - (30%)

  Fly     9 ILSHALIG----CGFFFLYVQHVRVIFETRTNIQQLNQLEREALLRREDALYYAFYKQLAEGPDF 69
            |||.|:.|    | ...|...::..:.|.......:.::|||...|.|..|||::|||:.:.|..
  Rat    45 ILSSAVGGTVALC-IGLLTSVYLATLHENDLWFSNIKEVEREISFRTECGLYYSYYKQMLQAPTL 108

  Fly    70 WHGYEQLKNVTDIEYPHSVNVLQRFYVLPELVTAYFFHVVRSGFNPMVQPMQFYLEFVWLMGGVT 134
            ..|:..|......|...::|:|||..:..|:..:..:.|:  .....::|:.||:..::.:..|.
  Rat   109 LQGFHGLIYDNKTESMRTINLLQRMNIYQEVFLSVLYRVL--PIQKYLEPVYFYIYTLFGLQAVY 171

  Fly   135 LLVLYLYGTLLSENIFGGIYGVISYLMFHSFVAKI-YERPLARENFAFPFIFLQMFYLCICIGRI 198
            :..||:...|||.....|:...:.|:.......:: :..|| |||:|.||..:|       |..|
  Rat   172 VTALYITSWLLSGTWLSGLLAALWYVTNRIDTTRVEFTIPL-RENWALPFFAIQ-------IAAI 228

  Fly   199 IHRQRHT----SRMFMIFAMSLFTACALLSWQFSTFIFTTQILIMMTSWNASALPTALVNAFVLD 259
            .:..|..    |....:.|:.:.|....|:|||:.|:...|.|::....:...|| |:...::..
  Rat   229 TYFLRPNLQPLSERLTLLAIFVSTFLFSLTWQFNQFMMLLQALVLFILDSLDMLP-AVKATWLYG 292

  Fly   260 YSLSHLLGHALAFVMSHGNSQLLLTWQLSISLFLFLITMVRQLRHVRSRRLGHAQDLLNGD-LFS 323
            ..:|.||   |..::...||.:|.:..:|.:|   .:.:||:|:          ::|..|. |..
  Rat   293 IQISCLL---LVCMLQFFNSMILGSLLISFNL---SVLIVRKLQ----------KNLKTGTFLIR 341

  Fly   324 LKFLMLTLLLASSVQTTLIELFNRAGVVSVTEGDQQHFFDICAHWALQVNVGFVAHLSACNPQYA 388
            :..|:|.|||...:...|..:..:   :...:.|:..|..:.|.:.......|.|:|..|...:.
  Rat   342 IWKLLLHLLLVFCLTLFLNNIIKK---ILNLKSDEHIFKFLKAKFGFGATRDFDANLYLCEEAFG 403

  Fly   389 RVAWSELWQLVKTMIVKPYCMYGVVMLAMFFRRWRKSGAPVSALTEEQRERARKYVLEDFIEEHF 453
            .:..:...:|.:|::...|....:|.:..         |.|.|                     |
  Rat   404 LLPLNTFQRLSETLLFYAYMFVLLVTVVT---------ASVVA---------------------F 438

  Fly   454 VSMSDMSSKETEKQLYKCFRLLKSCDYDYERYKRAQASLRKEQPPARDDFMQDIKRLRAQINRNS 518
            .::||.:|.                                 ||
  Rat   439 HNLSDSTSL---------------------------------QP--------------------- 449

  Fly   519 VKQRKERAQETKEAATDGASTPTEEEDKDPEAESESKKKNQEPGSGETETESAADPTETPPSRSA 583
            |.|.::|..:.|                 |||
  Rat   450 VDQTRKRVVDLK-----------------PEA--------------------------------- 464

  Fly   584 DNEEEEEEHSATAAGCGSNSSGHRQRKRSSSRRSSVVPTANAQILNMHYVYSFLQMLVFTLIGLA 648
                                                             .|:.:..::|.::.|:
  Rat   465 -------------------------------------------------AYNLIHTILFGVLALS 480

  Fly   649 VRKLFFLSFTQGCVIAP-TVC-SKLWYHRQRNI-------FWSVSLAVFLLSMFD------PGMV 698
            ..::.:|..:..||.|. .:| |::|....|.:       .|.:..:|.:|::..      |||:
  Rat   481 TMRMKYLWTSHMCVFASFGLCSSEIWELILRLVHLCNPKRIWVMRYSVPVLTLLCLCCKSWPGMM 545

  Fly   699 N----IREEYFPTRYSKSGDDLDSMLEWIKLNTERDAVFAGPVDIIGTVHLTTKRPIVNHAHLEM 759
            :    ::|.|.|        |...::.||..||.|.|||||.:.::..|.|.|.|.:.||.|.|.
  Rat   546 DELSELKEFYDP--------DTVELMNWINSNTPRKAVFAGSMQLLAGVKLCTGRTLTNHPHYED 602

  Fly   760 RQIAERTEHVYSVYSRQQSSDIYNQCAQLKIQYLIISLDECTNEVRD--DCDLLAIWD------- 815
            :.:.|||:.||.:|:::...:::.........::|:. |....|.|.  .|.|..:.|
  Rat   603 KSLRERTQAVYQIYAKRSPEEVHALLRSFGTDFVILE-DSICYERRHHRGCRLRDLLDVANGHEM 666

  Fly   816 --------DKQPAYQKYPQFCHELLHKNVPS----FLKVFANDHYGIIKM 853
                    |.:||  .:|:||.| :.:|:||    |.:||.|..:.:.|:
  Rat   667 DGPGESDPDLRPA--DHPRFCEE-IKRNLPSYAAHFTRVFQNKTFHVYKL 713

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG6659	NP_573317.1	Dpy19	18..852	CDD:287052	173/879 (20%)
		Neuromodulin	521..>599	CDD:284117	6/77 (8%)
Dpy19l3	NP_001129307.2	Dpy19	57..712	CDD:287052	174/880 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166338579
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4587
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1115173at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm46143
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	6	5.710