DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6659 and Dpy19l2

DIOPT Version :9

Sequence 1:	NP_573317.1	Gene:	CG6659 / 32854	FlyBaseID:	FBgn0030946	Length:	872	Species:	Drosophila melanogaster
Sequence 2:	XP_006242784.1	Gene:	Dpy19l2 / 300461	RGDID:	1564311	Length:	790	Species:	Rattus norvegicus

Alignment Length:	919	Identity:	193/919 - (21%)
Similarity:	326/919 - (35%)	Gaps:	300/919 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LYVILSH----------------ALIGCGFF--FLYVQHVRVIFETRTNIQQLNQLEREALLRRE 52
            |:.:|.|                .|.|...|  .|:..|:..:||...:...|:.||||...|.|
  Rat   100 LHTLLDHFREKVQALQIHRFSHRTLFGVAAFVGILHWLHLITLFENDRHFSHLSSLEREMTFRTE 164

  Fly    53 DALYYAFYKQLAEGPDFWHGYEQLKNVTDIEYPHSVNVLQRFYVLPELVTAYFFHVVRSGFN--- 114
            ..|||:::|.:.|.|.|..|...:.|....|||..:|.::||::.||::.|::|..|....|
  Rat   165 MGLYYSYFKTIIEAPSFLEGLWMIMNDRLTEYPLVINTVKRFHLYPEVIIAFWFRTVIGILNLFG 229

  Fly   115 -------------PM--VQ-------PMQFYLEFVWLMGGVTLLVLYLYGTLLSENIFGGIYGVI 157
                         |:  ||       |..||:..::::.|:.:.:.::|||.||.:..||:..|.
  Rat   230 IESKTCWNVTRMEPLNEVQSCEGLGDPACFYIGVIFILNGLMMGLFFIYGTYLSGSQLGGLITVA 294

  Fly   158 SYLMFHSFVAKIYERPLARENFAFPFIFLQMFYL-CICIGRIIHRQRHTSRMFMIFAMSLFTACA 221
            .|...|....::...|..||:|::||:.|||:.| .|.....||::.:.:..|...|.
  Rat   295 CYFFNHGEATRVMWTPPLRESFSYPFLVLQMYVLTTILRASTIHKKHYIALCFSNVAF------- 352

  Fly   222 LLSWQFSTFIFTTQILIMMTSWNASALPTALVNAFVLDYSLSHLL-----GHALAFVMSHGNSQL 281
            ||.|||:.||..|||        ||..|..:| .::.......::     ..||.|::..||...
  Rat   353 LLPWQFAQFILFTQI--------ASLFPMYVV-GYIEPSKFQKIIYINMGSVALCFILMFGNPMY 408

  Fly   282 LLTWQLSISLFLFLITMVRQLRHVRSRRLGHAQDLLNGDLFSLKFLMLTLLLASSVQ-------- 338
            |.::..|..:..:.|...:.                          .:..|:||.:|
  Rat   409 LSSYYSSCLIVSWAILQKKN--------------------------KIQKLVASELQFWLAQGCA 447

  Fly   339 ---TTLIELFNRAGVVSVTEGDQQHFFDICAHWALQVNVGFVAHLSACNPQYARVAWSELWQLVK 400
               .|:|..|..:.:..|:  |.....|:.|...|:. ..|...:..|.|::..:..:...:..|
  Rat   448 WWCGTIILKFGTSKICGVS--DHIRLSDLIAARILRY-TDFDTLIYTCAPEFDFMERATPLRYTK 509

  Fly   401 TMIVKPYCMYGVVMLAMFFRRWRKSGAPVSALTEEQRERARKYVLEDFIEEHFVSMSDMSSKETE 465
            |::: |..:  |:...:|                       |.::.|.:
  Rat   510 TLLL-PLVL--VITYLIF-----------------------KMIVRDIL---------------- 532

  Fly   466 KQLYKCFRLLKSCDYDYERYKRAQASLRKEQPPARDDFMQDIKRLRAQINRNSVKQRKERAQETK 530
                 |.....:    |:|......||:.:       |.||   ||.|:
  Rat   533 -----CVLYTNT----YQRILTRNESLKFK-------FYQD---LRKQL---------------- 562

  Fly   531 EAATDGASTPTEEEDKDPEAESESKKKNQEPGSGETETESAADPTETPPSRSADNEEEEEEHSAT 595
                                                                .||.|
  Rat   563 ----------------------------------------------------LDNGE-------- 567

  Fly   596 AAGCGSNSSGHRQRKRSSSRRSSVVPTANAQILNMHYVYSFLQMLVFTLIGLAVRKLFFLSFTQG 660
                                                .::..||:|.|..:.:.:.:|........
  Rat   568 ------------------------------------LIFHALQLLAFMGLAILIMRLKLFLTPHM 596

  Fly   661 CVIAPTVCSKLWY-------HRQRNIFWSVSLAVFLLSMFDPGMVNIREEYFPTRYSKSGD---- 714
            |::|..:||:..:       |.:..:|.      .|..|...|..|:..:     :|..|:
  Rat   597 CLMASLICSRRLFGWLFCRIHFENVVFG------ILTMMSIQGCANLHNQ-----WSIMGEFTNL 650

  Fly   715 DLDSMLEWIKLNTERDAVFAGPVDIIGTVHLTTKRPIVNHAHLEMRQIAERTEHVYSVYSRQQSS 779
            ..:.::.||:.||..||||||.:..:.::.|:|..|||||.|.|...:..||:.|||.|||:.:.
  Rat   651 PQEELIHWIRHNTRPDAVFAGAMPTMASIKLSTLHPIVNHPHYEDADLRARTKIVYSAYSRKPAV 715

  Fly   780 DIYNQCAQLKIQYLIISLDECTNEVRDDCDLLAIWDDKQPAYQKYPQFCHELLHKNVPSFLKVFA 844
            ::.|:..:|.:.|.::....|....:..|.:|.|||.:.|:....|..|..||..:.|.|..||.
  Rat   716 EVRNKLLELHVNYYVLEEAWCVVRTKPGCSMLEIWDVEDPSNAANPPLCSILLKDSRPYFTTVFQ 780

  Fly   845 NDHYGIIKM 853
            |..|.::|:
  Rat   781 NSMYRVLKI 789

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6659	NP_573317.1	Dpy19	18..852	CDD:287052	187/888 (21%)
CG6659	NP_573317.1	Neuromodulin	521..>599	CDD:284117	3/77 (4%)
Dpy19l2	XP_006242784.1	Dpy19	130..788	CDD:287052	187/886 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	238	1.000	Domainoid score	I2226
eggNOG	1	0.900	-	-		E1_KOG4587
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	240	1.000	Inparanoid score	I3261
OMA	1	1.010	-	-		QHG47962
OrthoDB	1	1.010	-	-		D1115173at2759
OrthoFinder	1	1.000	-	-		FOG0004434
OrthoInspector	1	1.000	-	-		otm46143
orthoMCL	1	0.900	-	-		OOG6_107418
Panther	1	1.100	-	-	O	PTHR31488
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.880