Protein Alignment CG6659 and DPY19L1

DIOPT Version :10

• Sequence 1: NP_573317.1
• Gene: CG6659 / 32854
• FlyBaseID: FBgn0030946
• Length: 872
• Species: Drosophila melanogaster
• Sequence 2: NP_001353602.1
• Gene: DPY19L1 / 23333
• HGNCID: 22205
• Length: 748
• Species: Homo sapiens
• Alignment Length: 904
• Identity: 183/904 - (20%)
• Similarity: 327/904 - (36%)
• Gaps: 330/904 - (36%)

  Fly    22 LYVQHVRVIFETRTNIQQLNQLEREALLRREDALYYAFYKQLAEGPDFWHGYEQLKNVTDIEYPH 86
            |:..|:..:||...:...|:.||||...|.|..|||:::|.:.|.|.|.:|...:.|....|||.
Human   106 LHWSHITHLFENDRHFSHLSTLEREMAFRTEMGLYYSYFKTIVEAPSFLNGVWMIMNDKLTEYPL 170

  Fly    87 SVNVLQRFYVLPELVTAYFFHVVR-------------------SGFNP------MVQPMQFYLEF 126
            .:|.|:||.:.||::.|.::.:..                   .|.:|      :..|..||:..
Human   171 VINTLKRFNLYPEVILASWYRIYTKIMDLIGIQTKICWTVTRGEGLSPIESCEGLGDPACFYVAV 235

  Fly   127 VWLMGGVTLLVLYLYGTLLSENIFGGIYGVISYLMFHSFVAKIYERPLARENFAFPFIFLQMFYL 191
            ::::.|:.:.:.::|||.||.:..||:..|:.:...|....::...|..||:|::||:.|||..:
Human   236 IFILNGLMMALFFIYGTYLSGSRLGGLVTVLCFFFNHGECTRVMWTPPLRESFSYPFLVLQMLLV 300

  Fly   192 CICIGRIIHRQRHTSRMFMIFAMSLFTACA-----LLSWQFSTFIFTTQILIMMTSWNASALPTA 251
                       .|..|...::..||...|.     :|.|||:.|:..|||             .:
Human   301 -----------THILRATKLYRGSLIALCISNVFFMLPWQFAQFVLLTQI-------------AS 341

  Fly   252 LVNAFVLDY---------SLSHLLGHALAFVMSHGNSQLLLTWQLSISLFLFLITMVRQLRHVRS 307
            |...:|:.|         ...|::..||.||:..|||.||.::..|..:.::
Human   342 LFAVYVVGYIDICKLRKIIYIHMISLALCFVLMFGNSMLLTSYYASSLVIIW------------- 393

  Fly   308 RRLGHAQDLLNGDLFSLKFLMLTLLLASSVQTTLIELFNRAGVVSVTEGDQQHFFDICAHWALQV 372
                                                     |::::    :.||        |::
Human   394 -----------------------------------------GILAM----KPHF--------LKI 405

  Fly   373 NVGFVAHLSACNPQYARVAWSELWQLVKTMIVKPYCMYGVVMLAMFFRRWRKSGAPVSALTEEQR 437
            |   |:.||             ||     :|...:.::|.|:|
Human   406 N---VSELS-------------LW-----VIQGCFWLFGTVIL---------------------- 427

  Fly   438 ERARKY-------VLEDFIEEHFVSMSDMSSKETEKQLYKCFRLLKSCDYDYERYKRAQASLRKE 495
                ||       :.:|....:.::....|.|:.:..||.|     :.::|:         :.||
Human   428 ----KYLTSKIFGIADDAHIGNLLTSKFFSYKDFDTLLYTC-----AAEFDF---------MEKE 474

  Fly   496 QPPARDD----------FMQDIKRLRAQINRNSVKQRKERAQETKEAATDGASTPTEEEDKDPEA 550
            .|.....          |:..::::.:.:.....||
Human   475 TPLRYTKTLLLPVVLVVFVAIVRKIISDMWGVLAKQ----------------------------- 510

  Fly   551 ESESKKKNQEPGSGETETESAADPTETPPSRSADNEEEEEEHSATAAGCGSNSSGHRQRKRSSSR 615
            ::..:|...:.|
Human   511 QTHVRKHQFDHG----------------------------------------------------- 522

  Fly   616 RSSVVPTANAQILNMHYVYSFLQMLVFTLIGLAVRKLFFLSFTQGCVIAPTVCSKLWYHRQRNIF 680
                           ..||..||:|.:|.:|:.:.:|........||:|..:||       |.:|
Human   523 ---------------ELVYHALQLLAYTALGILIMRLKLFLTPHMCVMASLICS-------RQLF 565

  Fly   681 -W--------SVSLAVFLLSMFDPGMVNIREEYFPTRYSKSGD----DLDSMLEWIKLNTERDAV 732
             |        ::..|: |.:|...|..|::     |:::..|:    ..:.::||||.:|:.|||
Human   566 GWLFCKVHPGAIVFAI-LAAMSIQGSANLQ-----TQWNIVGEFSNLPQEELIEWIKYSTKPDAV 624

  Fly   733 FAGPVDIIGTVHLTTKRPIVNHAHLEMRQIAERTEHVYSVYSRQQSSDIYNQCAQLKIQYLIISL 797
            |||.:..:.:|.|:..||||||.|.|...:..||:.|||:|||:.:.::..:..:||:.|.|:..
Human   625 FAGAMPTMASVKLSALRPIVNHPHYEDAGLRARTKIVYSMYSRKAAEEVKRELIKLKVNYYILEE 689

  Fly   798 DECTNEVRDDCDLLAIWDDKQPAYQKYPQFCHELLHKNVPSFLKVFANDHYGIIKMFSQ 856
            ..|....:..|.:..|||.:.||.......|:.|:..:.|.|..||.|..|.::::..:
Human   690 SWCVRRSKPGCSMPEIWDVEDPANAGKTPLCNLLVKDSKPHFTTVFQNSVYKVLEVVKE 748

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG6659	NP_573317.1	Dpy19	17..853	CDD:462945	183/899 (20%)
DPY19L1	NP_001353602.1	Dpy19L1	92..743	CDD:439131	183/897 (20%)
		putative TM segment 1	92..108	CDD:439131	1/1 (100%)
		putative TM segment 2	228..249	CDD:439131	4/20 (20%)
		putative TM segment 3	253..269	CDD:439131	5/15 (33%)
		putative TM segment 4	289..303	CDD:439131	5/24 (21%)
		putative TM segment 5	312..327	CDD:439131	3/14 (21%)
		putative TM segment 6	333..351	CDD:439131	6/30 (20%)
		putative TM segment 7	359..376	CDD:439131	5/16 (31%)
		putative TM segment 8	379..395	CDD:439131	3/69 (4%)
		putative TM segment 9	413..431	CDD:439131	7/48 (15%)
		putative TM segment 10	483..504	CDD:439131	1/20 (5%)
		putative TM segment 11	528..544	CDD:439131	5/15 (33%)
		putative TM segment 12	548..570	CDD:439131	8/28 (29%)
		putative TM segment 13	574..589	CDD:439131	3/15 (20%)