Protein Alignment CG6659 and Dpy19l3

DIOPT Version :10

• Sequence 1: NP_573317.1
• Gene: CG6659 / 32854
• FlyBaseID: FBgn0030946
• Length: 872
• Species: Drosophila melanogaster
• Sequence 2: NP_848819.2
• Gene: Dpy19l3 / 233115
• MGIID: 2443952
• Length: 716
• Species: Mus musculus
• Alignment Length: 895
• Identity: 183/895 - (20%)
• Similarity: 323/895 - (36%)
• Gaps: 276/895 - (30%)

  Fly     9 ILSHALIG----CGFFFLYVQHVRVIFETRTNIQQLNQLEREALLRREDALYYAFYKQLAEGPDF 69
            |||.|:.|    | ...|...::..:.|.......:.::|||...|.|..|||::|||:.:.|..
Mouse    44 ILSSAVGGTVALC-IGLLTSVYLATLHENDLWFSNIKEVEREISFRTECGLYYSYYKQMLQAPTL 107

  Fly    70 WHGYEQLKNVTDIEYPHSVNVLQRFYVLPELVTAYFFHVVRSGFNPMVQPMQFYLEFVWLMGGVT 134
            ..|:..|......|...::|:|||..:..|:..:..:.|:  .....::|:.||:..::.:..|.
Mouse   108 LQGFHGLIYDNKTESMRTINLLQRMNIYQEVFLSVLYRVL--PIQKYLEPVYFYIYTLFGLQAVY 170

  Fly   135 LLVLYLYGTLLSENIFGGIYGVISYLMFHSFVAKI-YERPLARENFAFPFIFLQMFYLCICIGRI 198
            :..||:...|||.....|:...:.|:.......:: :..|| |||:|.||..:|       |..|
Mouse   171 VTALYITSWLLSGTWLSGLLAALWYVTNRIDTTRVEFTIPL-RENWALPFFAIQ-------IAAI 227

  Fly   199 IHRQRHT----SRMFMIFAMSLFTACALLSWQFSTFIFTTQILIMMTSWNASALPTALVNAFVLD 259
            .:..|..    |....:.|:.:.|....|:|||:.|:...|.|::....:...|| |:...::..
Mouse   228 TYFLRPNLQPLSERLTLLAIFVSTFLFSLTWQFNQFMMLLQALVLFILDSLDMLP-AMKATWLYG 291

  Fly   260 YSLSHLLGHALAFVMSHGNSQLLLTWQLSISLFLFLITMVRQLRHVRSRRLGHAQDLLNGD-LFS 323
            ..:|.||   |...:...||.:|.:..:|.:|   .:.:||:|:          ::|..|. |..
Mouse   292 IQISCLL---LVCTLQFFNSMILGSLLISFNL---SVLIVRKLQ----------KNLKTGSFLTR 340

  Fly   324 LKFLMLTLLLASSVQTTLIELFNRAGVVSVTEGDQQHFFDICAHWALQVNVGFVAHLSACNPQYA 388
            :..|:|.|||...:...|..:..:   |...:.|:..|..:.|.:.......|.|:|..|...:.
Mouse   341 IWKLLLHLLLVFCLTLFLNNIIKK---VLNLKSDEHIFKFLKAKFGFGATRDFDANLYLCEEAFG 402

  Fly   389 RVAWSELWQLVKTMIVKPYCMYGVVMLAMFFRRWRKSGAPVSALTEEQRERARKYVLEDFIEEHF 453
            .:..:...:|.:|::...|....||.:..         |.|.|                     |
Mouse   403 LLPLNTFQRLSETLLFYAYMFVLVVTVVT---------ASVVA---------------------F 437

  Fly   454 VSMSDMSSKETEKQLYKCFRLLKSCDYDYERYKRAQASLRKEQPPARDDFMQDIKRLRAQINRNS 518
            .::||.:|             |||.|
Mouse   438 HNLSDSTS-------------LKSMD--------------------------------------- 450

  Fly   519 VKQRKERAQETKEAATDGASTPTEEEDKDPEAESESKKKNQEPGSGETETESAADPTETPPSRSA 583
              |.::||.:.|                 |||
Mouse   451 --QTRKRAVDLK-----------------PEA--------------------------------- 463

  Fly   584 DNEEEEEEHSATAAGCGSNSSGHRQRKRSSSRRSSVVPTANAQILNMHYVYSFLQMLVFTLIGLA 648
                                                             .|:.:..::|.::.|:
Mouse   464 -------------------------------------------------AYNLIHTILFGVLALS 479

  Fly   649 VRKLFFLSFTQGCVIAP-TVC-SKLWYHRQRNI-------FWSVSLAVFLLSMFD------PGMV 698
            ..::.:|..:..||.|. .:| |::|....|.:       .|.:...|.:|::..      ||::
Mouse   480 TMRMKYLWTSHMCVFASFGLCSSEVWELLLRLVHLCNPKRIWVLRYLVPVLTLLYLCYKSWPGVM 544

  Fly   699 N----IREEYFPTRYSKSGDDLDSMLEWIKLNTERDAVFAGPVDIIGTVHLTTKRPIVNHAHLEM 759
            :    ::|.|.|        |...::.||..||.|.|||||.:.::..|.|.|.|.:.||.|.|.
Mouse   545 DELSELKEFYDP--------DTVELMTWINSNTPRKAVFAGSMQLLAGVKLCTGRTLTNHPHYED 601

  Fly   760 RQIAERTEHVYSVYSRQQSSDIYNQCAQLKIQYLIISLDECTNEVRD--DCDLLAIWD------- 815
            :.:.|||:.||.:|:::...:::.........::|:. |....|.|.  .|.|..:.|
Mouse   602 KSLRERTQAVYQIYAKRSPEEVHALLRSFGTDFVILE-DSICYERRHHRGCRLRDLLDVANGHEM 665

  Fly   816 --------DKQPAYQKYPQFCHELLHKNVPS----FLKVFANDHYGIIKM 853
                    |.:||  .:|:||.| :.:|:||    |.:||.|..:.:.|:
Mouse   666 DGPGESDPDLRPA--DHPRFCEE-IKRNLPSYAAHFTRVFQNKTFHVYKL 712

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG6659	NP_573317.1	Dpy19	17..853	CDD:462945	177/881 (20%)
Dpy19l3	NP_848819.2	Dpy19L3	46..712	CDD:439134	180/891 (20%)
		putative TM segment 1	46..62	CDD:439134	5/16 (31%)
		putative TM segment 2	155..176	CDD:439134	5/20 (25%)
		putative TM segment 3	180..196	CDD:439134	4/15 (27%)
		putative TM segment 4	216..230	CDD:439134	6/20 (30%)
		putative TM segment 5	242..257	CDD:439134	2/14 (14%)
		putative TM segment 6	263..281	CDD:439134	3/17 (18%)
		putative TM segment 7	289..306	CDD:439134	4/19 (21%)
		putative TM segment 8	309..325	CDD:439134	3/18 (17%)
		putative TM segment 9	344..362	CDD:439134	6/17 (35%)
		putative TM segment 10	416..437	CDD:439134	6/50 (12%)
		putative TM segment 11	467..483	CDD:439134	2/15 (13%)
		putative TM segment 12	487..509	CDD:439134	6/21 (29%)
		putative TM segment 13	524..539	CDD:439134	2/14 (14%)