DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6659 and Dpy19l3

DIOPT Version :9

Sequence 1:	NP_573317.1	Gene:	CG6659 / 32854	FlyBaseID:	FBgn0030946	Length:	872	Species:	Drosophila melanogaster
Sequence 2:	NP_848819.2	Gene:	Dpy19l3 / 233115	MGIID:	2443952	Length:	716	Species:	Mus musculus

Alignment Length:	895	Identity:	183/895 - (20%)
Similarity:	323/895 - (36%)	Gaps:	276/895 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 ILSHALIG----CGFFFLYVQHVRVIFETRTNIQQLNQLEREALLRREDALYYAFYKQLAEGPDF 69
            |||.|:.|    | ...|...::..:.|.......:.::|||...|.|..|||::|||:.:.|..
Mouse    44 ILSSAVGGTVALC-IGLLTSVYLATLHENDLWFSNIKEVEREISFRTECGLYYSYYKQMLQAPTL 107

  Fly    70 WHGYEQLKNVTDIEYPHSVNVLQRFYVLPELVTAYFFHVVRSGFNPMVQPMQFYLEFVWLMGGVT 134
            ..|:..|......|...::|:|||..:..|:..:..:.|:  .....::|:.||:..::.:..|.
Mouse   108 LQGFHGLIYDNKTESMRTINLLQRMNIYQEVFLSVLYRVL--PIQKYLEPVYFYIYTLFGLQAVY 170

  Fly   135 LLVLYLYGTLLSENIFGGIYGVISYLMFHSFVAKI-YERPLARENFAFPFIFLQMFYLCICIGRI 198
            :..||:...|||.....|:...:.|:.......:: :..|| |||:|.||..:|       |..|
Mouse   171 VTALYITSWLLSGTWLSGLLAALWYVTNRIDTTRVEFTIPL-RENWALPFFAIQ-------IAAI 227

  Fly   199 IHRQRHT----SRMFMIFAMSLFTACALLSWQFSTFIFTTQILIMMTSWNASALPTALVNAFVLD 259
            .:..|..    |....:.|:.:.|....|:|||:.|:...|.|::....:...|| |:...::..
Mouse   228 TYFLRPNLQPLSERLTLLAIFVSTFLFSLTWQFNQFMMLLQALVLFILDSLDMLP-AMKATWLYG 291

  Fly   260 YSLSHLLGHALAFVMSHGNSQLLLTWQLSISLFLFLITMVRQLRHVRSRRLGHAQDLLNGD-LFS 323
            ..:|.||   |...:...||.:|.:..:|.:|   .:.:||:|:          ::|..|. |..
Mouse   292 IQISCLL---LVCTLQFFNSMILGSLLISFNL---SVLIVRKLQ----------KNLKTGSFLTR 340

  Fly   324 LKFLMLTLLLASSVQTTLIELFNRAGVVSVTEGDQQHFFDICAHWALQVNVGFVAHLSACNPQYA 388
            :..|:|.|||...:...|..:..:   |...:.|:..|..:.|.:.......|.|:|..|...:.
Mouse   341 IWKLLLHLLLVFCLTLFLNNIIKK---VLNLKSDEHIFKFLKAKFGFGATRDFDANLYLCEEAFG 402

  Fly   389 RVAWSELWQLVKTMIVKPYCMYGVVMLAMFFRRWRKSGAPVSALTEEQRERARKYVLEDFIEEHF 453
            .:..:...:|.:|::...|....||.:..         |.|.|                     |
Mouse   403 LLPLNTFQRLSETLLFYAYMFVLVVTVVT---------ASVVA---------------------F 437

  Fly   454 VSMSDMSSKETEKQLYKCFRLLKSCDYDYERYKRAQASLRKEQPPARDDFMQDIKRLRAQINRNS 518
            .::||.:|             |||.|
Mouse   438 HNLSDSTS-------------LKSMD--------------------------------------- 450

  Fly   519 VKQRKERAQETKEAATDGASTPTEEEDKDPEAESESKKKNQEPGSGETETESAADPTETPPSRSA 583
              |.::||.:.|                 |||
Mouse   451 --QTRKRAVDLK-----------------PEA--------------------------------- 463

  Fly   584 DNEEEEEEHSATAAGCGSNSSGHRQRKRSSSRRSSVVPTANAQILNMHYVYSFLQMLVFTLIGLA 648
                                                             .|:.:..::|.::.|:
Mouse   464 -------------------------------------------------AYNLIHTILFGVLALS 479

  Fly   649 VRKLFFLSFTQGCVIAP-TVC-SKLWYHRQRNI-------FWSVSLAVFLLSMFD------PGMV 698
            ..::.:|..:..||.|. .:| |::|....|.:       .|.:...|.:|::..      ||::
Mouse   480 TMRMKYLWTSHMCVFASFGLCSSEVWELLLRLVHLCNPKRIWVLRYLVPVLTLLYLCYKSWPGVM 544

  Fly   699 N----IREEYFPTRYSKSGDDLDSMLEWIKLNTERDAVFAGPVDIIGTVHLTTKRPIVNHAHLEM 759
            :    ::|.|.|        |...::.||..||.|.|||||.:.::..|.|.|.|.:.||.|.|.
Mouse   545 DELSELKEFYDP--------DTVELMTWINSNTPRKAVFAGSMQLLAGVKLCTGRTLTNHPHYED 601

  Fly   760 RQIAERTEHVYSVYSRQQSSDIYNQCAQLKIQYLIISLDECTNEVRD--DCDLLAIWD------- 815
            :.:.|||:.||.:|:::...:::.........::|:. |....|.|.  .|.|..:.|
Mouse   602 KSLRERTQAVYQIYAKRSPEEVHALLRSFGTDFVILE-DSICYERRHHRGCRLRDLLDVANGHEM 665

  Fly   816 --------DKQPAYQKYPQFCHELLHKNVPS----FLKVFANDHYGIIKM 853
                    |.:||  .:|:||.| :.:|:||    |.:||.|..:.:.|:
Mouse   666 DGPGESDPDLRPA--DHPRFCEE-IKRNLPSYAAHFTRVFQNKTFHVYKL 712

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6659	NP_573317.1	Dpy19	18..852	CDD:287052	176/879 (20%)
CG6659	NP_573317.1	Neuromodulin	521..>599	CDD:284117	7/77 (9%)
Dpy19l3	NP_848819.2	Dpy19	56..711	CDD:287052	177/880 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167834988
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4587
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1115173at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm44054
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	6	5.710