Protein Alignment CG6659 and dpy-19

DIOPT Version :9

• Sequence 1: NP_573317.1
• Gene: CG6659 / 32854
• FlyBaseID: FBgn0030946
• Length: 872
• Species: Drosophila melanogaster
• Sequence 2: NP_498909.1
• Gene: dpy-19 / 191628
• WormBaseID: WBGene00001078
• Length: 683
• Species: Caenorhabditis elegans
• Alignment Length: 892
• Identity: 187/892 - (20%)
• Similarity: 316/892 - (35%)
• Gaps: 285/892 - (31%)

  Fly     8 VILSHALIGCGFFFLYVQHVRVIFETRTNIQQLNQLEREALLRREDALYYAFYKQLAEGPDFWHG 72
            |::...|:|    ::..|||..:||...:...|...|||...|.|..|||::||.:...|.|..|
 Worm    31 VVIIGLLVG----YINYQHVYTLFENDKHFSHLADFEREMAYRTEMGLYYSYYKTIINAPSFLEG 91

  Fly    73 YEQLKNVTDIEYPHSVNVLQRFYVLPELVTAYFF------------------HVVRSGFNPMV-- 117
            .:::.:.|..|:.|.:|.|.||.:.||::.|:.:                  .|.|....|:.
 Worm    92 VQEITHDTVTEHGHEINTLNRFNLYPEVILAFLYRPFRAFAKSANWQIELCWQVNRGELRPVESC 156

  Fly   118 ----QPMQFYLEFVWLMGGVTLLVLYLYGTLLSENIFGGIYGVISYLMFHSFVAKIYERPLAREN 178
                .|..||:..|:::.|.....::..|.|:|::||||...|:.:...|....::...|..||:
 Worm   157 EGIGNPHYFYITGVFIVAGTVASSIFYLGVLVSDSIFGGFLSVLCFAFNHGEATRVQWTPPLRES 221

  Fly   179 FAFPFIFLQMFYLCICIGRIIHRQRHTSRMFMIFAMSLFTACALLSWQFSTFIFTTQILIMMTSW 243
            ||||||...:..|...|.  ..:..|:    ||..::.....|||.|||:.|.|.|||..:..::
 Worm   222 FAFPFIIGHIAILTFVIK--YKKSGHS----MILLLTSMAVPALLFWQFTQFAFFTQICSIFLAF 280

  Fly   244 NASALPTALVNAFVLDYSLSHLLGHALAFVMSHGNSQLLLTWQLSISLFLFLITMVRQLRHVRSR 308
            :...:|.:.....:..:.:|.|:|..|.|    ||..::........|.|.:|..:..|
 Worm   281 SLDLIPFSTAKTVIHSHIISFLIGFLLLF----GNEMMITALYFPSILALGMIIYISPL------ 335

  Fly   309 RLGHAQDLLNGDLFSLKF-----LMLTLLLASSVQTTLIELFNRAGVVSVTEGDQQHFFDIC-AH 367
                        |.:|||     |.|.::.||......|.|....|:     .|..|.|||. :.
 Worm   336 ------------LSNLKFRPAYVLFLAIIFASITLGLKIGLSKGLGI-----EDDAHIFDILRSK 383

  Fly   368 WALQVNVGFVAHLSACNPQYARVAWSELWQLVKTMIVKPYCMYGVVMLAMFFRR-----WRKSGA 427
            :....|  |...|..|:.::..:.:|.:.:|..|::: |..:..:|.....|.:     ||
 Worm   384 FTSFAN--FHTRLYTCSAEFDFIQYSTIEKLCGTLLI-PLALISLVTFVFNFVKNTNLLWR---- 441

  Fly   428 PVSALTEEQRERARKYVLEDFIEEHFVSMSDMSSKETEKQLYKCFRLLKSCDYDYERYKRAQASL 492
                                                                             
 Worm   442 ----------------------------------------------------------------- 441

  Fly   493 RKEQPPARDDFMQDIKRLRAQINRNSVKQRKERAQETKEAATDGASTPTEEEDKDPEAESESKKK 557
                                                                             
 Worm   442 ----------------------------------------------------------------- 441

  Fly   558 NQEPGSGETETESAADPTETPPSRSADNEEEEEEHSATAAGCGSNSSGHRQRKRSSSRRSSVVPT 622
                                       |.||..|
 Worm   442 ---------------------------NSEEIGE------------------------------- 448

  Fly   623 ANAQILNMHYVYSFLQMLVFTLIGLAVRKLFFLSFTQGCVIAPTVC-SKLWYHRQRNIFWSVSLA 686
             |.:||     |:.:|:...|::...:.:|........|::|.... |||....:.:....||..
 Worm   449 -NGEIL-----YNVVQLCCSTVMAFLIMRLKLFMTPHLCIVAALFANSKLLGGDRISKTIRVSAL 507

  Fly   687 VFLLS-MFDPGMVNIREEYFPTRYSKSGDDLDSMLEWIKLNTERDAVFAGPVDIIGTVHLTTKRP 750
            |.::: :|..|:.|||:: ...:...|..|.:.:.:||:.||::||||||.:.::..|.|||.||
 Worm   508 VGVIAILFYRGIPNIRQQ-LNVKGEYSNPDQEMLFDWIQHNTKQDAVFAGTMPVMANVKLTTLRP 571

  Fly   751 IVNHAHLEMRQIAERTEHVYSVYSRQQSSDIYNQCAQLKIQYLIISLDECTN-EVRDDCDLLAIW 814
            ||||.|.|...|.|||..|||::|::..::::....::.:.|.:..|..|:| |.|.:|....:|
 Worm   572 IVNHPHYEHVGIRERTLKVYSMFSKKPIAEVHKIMKEMGVNYFVFQLMNCSNDERRPECVYRGMW 636

  Fly   815 DDKQPAYQKYPQFCHELL-------HKNVPSFLKVF-ANDHYGIIKM 853
            |::.|........|...:       :..:..|..|: ||.:|.::|:
 Worm   637 DEEDPKNSGRTALCDLWILAANSKDNSRIAPFKIVYNANRNYIVLKI 683

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG6659	NP_573317.1	Dpy19	18..852	CDD:287052	183/879 (21%)
		Neuromodulin	521..>599	CDD:284117	4/77 (5%)
dpy-19	NP_498909.1	Dpy19	37..682	CDD:287052	185/883 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	236	1.000	Domainoid score	I1315
eggNOG	1	0.900	-	-		E1_KOG4587
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	238	1.000	Inparanoid score	I2124
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG47962
OrthoDB	1	1.010	-	-		D1115173at2759
OrthoFinder	1	1.000	-	-		FOG0004434
OrthoInspector	1	1.000	-	-		oto20366
orthoMCL	1	0.900	-	-		OOG6_107418
Panther	1	1.100	-	-	LDO	PTHR31488
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2493
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.870