DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6659 and dpy19l1

DIOPT Version :9

Sequence 1:	NP_573317.1	Gene:	CG6659 / 32854	FlyBaseID:	FBgn0030946	Length:	872	Species:	Drosophila melanogaster
Sequence 2:	XP_031748748.1	Gene:	dpy19l1 / 100485357	XenbaseID:	XB-GENE-6040559	Length:	755	Species:	Xenopus tropicalis

Alignment Length:	892	Identity:	203/892 - (22%)
Similarity:	338/892 - (37%)	Gaps:	281/892 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 VILSHALIGCGFFFLYVQHVRVIFETRTNIQQLNQLEREALLRREDALYYAFYKQLAEGPDFWHG 72
            ::|...::|    .|:..|:..:||...:...|:.||||...|.|..|||:::|.:.|.|.|:.|
Frog    94 ILLFGVVVG----VLHWGHISTLFENDRHFSHLSTLEREMAFRTEMGLYYSYFKTMTEAPSFYSG 154

  Fly    73 YEQLKNVTDIEYPHSVNVLQRFYVLPELVTAYFFHV-----------------VRSG--FNP--- 115
            ..|:.|....|||..:|.||||.:.||::.|.:|.|                 |..|  .:|
Frog   155 LHQIMNDNITEYPKVINTLQRFNLYPEMILASWFRVYTQTMDYLGYKTKLCWTVNRGDELSPVES 219

  Fly   116 ---MVQPMQFYLEFVWLMGGVTLLVLYLYGTLLSENIFGGIYGVISYLMFHSFVAKIYERPLARE 177
               :..|..||:..:::..|..:...|:|||.||.:..||...|:|:...|....::...|..||
Frog   220 CEGLGDPAYFYVTMIFIWNGAMMFFFYIYGTFLSGSRLGGFLVVLSFFFNHGECTRVMWTPPLRE 284

  Fly   178 NFAFPFIFLQMFYLCICIGRIIHRQRHTSRMFMIFAMSLFTACALLSWQFSTFIFTTQILIMMTS 242
            :|::||:.||||.|     ..|.|.::.||. .:||:.:...|.:|.|||:.|:..|||..:...
Frog   285 SFSYPFLVLQMFLL-----TYILRAQNVSRQ-SLFALGVSNVCFMLPWQFAQFVLLTQIASLFAI 343

  Fly   243 WNASALPTALVNAF-VLDYSLSHLLGHALAFVMSHGNSQLLLTWQLSISLFLFLITMVRQL---- 302
            :     .|..:|:. .|....:|::...:.|::..|||.||.::..|..:.|.:|....:|
Frog   344 Y-----ITGFINSSKFLSILYTHMVSLGICFILMFGNSMLLTSYYASSLIVLCVIARNEELFLRL 403

  Fly   303 --RHVRSRRLGHAQDLLNGDLFSLKFLMLTLLLASSVQTTLIELFNRAGVVSVTEGDQQHFFDIC 365
              |||           :...|..|.:::.|:||.:.|...|            ...|..|..::
Frog   404 QTRHV-----------IFWILHVLSWVVGTVLLKAGVSKLL------------GAADDAHIGNL- 444

  Fly   366 AHWALQVNVGFVAH------LSACNPQYARVAWSELWQLVKTMIVKPYCMYGVVMLAMFFRRWRK 424
                  :...|.|:      :..|..::..:.....|:.:||:::
Frog   445 ------LKSKFTAYKDFDTLMYTCAAEFDFMERETPWRYLKTLLL-------------------- 483

  Fly   425 SGAPVSALTEEQRERARKYVLEDFIEEHFVSMSDMSSKETEKQLYKCFRLLKSCDYDYERYKRAQ 489
               |:..:.                   |:::              |.:.|
Frog   484 ---PIVIIV-------------------FIAI--------------CVQAL-------------- 498

  Fly   490 ASLRKEQPPARDDFMQDIKRLRAQINRNSVKQRKERAQETKEAATDGASTPTEEEDKDPEAESES 554
                                                                    :|.:..:.:
Frog   499 --------------------------------------------------------RDLQISTSA 507

  Fly   555 KKKNQEPGSGETETESAADPTETPPSRSADNEEEEEEHSATAAGCGSNSSGHRQRKRSSSRRSSV 619
            |      |||          .:.||:...       ||||    ||
Frog   508 K------GSG----------AKNPPNGRL-------EHSA----CG------------------- 526

  Fly   620 VPTANAQILNMHYVYSFLQMLVFTLIGLAVRKL-FFLSFTQGCVIAPTVCSKL---WYHRQ--RN 678
                       ..||..||::.|..:.:.:.:| .||| ...|::|..:|||.   |...:  ::
Frog   527 -----------ELVYHALQLVAFAALAVLIMRLKLFLS-PHMCIMASLLCSKQLFGWISTRVHQS 579

  Fly   679 IFWSVSLAVFLLSMFDPGMVNIREEYFPTRYSKSGDDLDSMLEWIKLNTERDAVFAGPVDIIGTV 743
            :|  |.:.|.|:|:  .|..|::.:: ..:...|....:.:||||..||...|||||.:..:.:|
Frog   580 VF--VFIIVGLMSV--QGYSNLQSQW-NIKGEFSNLPQEELLEWIHSNTNPGAVFAGAMPTMASV 639

  Fly   744 HLTTKRPIVNHAHLEMRQIAERTEHVYSVYSRQQSSDIYNQCAQLKIQYLIISLDECTNEVRDDC 808
            .|:|.||||||.|.|...:..||:.|||:|||:.:.::.|....:.:.:.|:....||...:..|
Frog   640 KLSTGRPIVNHPHYEDTDLRARTKKVYSMYSRKPAKEVKNTLLGMGVDFFILEDTWCTRRTKPGC 704

  Fly   809 DLLAIWDDKQPAYQKYPQFCHELLHKNVPSFLKVFANDHYGIIKMFS 855
            .|..|||.:.|........|..:..::.|.||.||.|   ||.|:.|
Frog   705 SLPEIWDIEDPENAGKVPLCSMMGKESRPHFLTVFNN---GIYKVLS 748

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6659	NP_573317.1	Dpy19	18..852	CDD:287052	199/877 (23%)
CG6659	NP_573317.1	Neuromodulin	521..>599	CDD:284117	11/77 (14%)
dpy19l1	XP_031748748.1	Dpy19	100..749	CDD:401862	202/886 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	258	1.000	Domainoid score	I1970
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	258	1.000	Inparanoid score	I3060
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1115173at2759
OrthoFinder	1	1.000	-	-		FOG0004434
OrthoInspector	1	1.000	-	-		otm49228
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.060