Protein Alignment CG6659 and dpy19l1

DIOPT Version :10

• Sequence 1: NP_573317.1
• Gene: CG6659 / 32854
• FlyBaseID: FBgn0030946
• Length: 872
• Species: Drosophila melanogaster
• Sequence 2: XP_031748748.1
• Gene: dpy19l1 / 100485357
• XenbaseID: XB-GENE-6040559
• Length: 755
• Species: Xenopus tropicalis
• Alignment Length: 892
• Identity: 203/892 - (22%)
• Similarity: 338/892 - (37%)
• Gaps: 281/892 - (31%)

  Fly     8 VILSHALIGCGFFFLYVQHVRVIFETRTNIQQLNQLEREALLRREDALYYAFYKQLAEGPDFWHG 72
            ::|...::|    .|:..|:..:||...:...|:.||||...|.|..|||:::|.:.|.|.|:.|
 Frog    94 ILLFGVVVG----VLHWGHISTLFENDRHFSHLSTLEREMAFRTEMGLYYSYFKTMTEAPSFYSG 154

  Fly    73 YEQLKNVTDIEYPHSVNVLQRFYVLPELVTAYFFHV-----------------VRSG--FNP--- 115
            ..|:.|....|||..:|.||||.:.||::.|.:|.|                 |..|  .:|
 Frog   155 LHQIMNDNITEYPKVINTLQRFNLYPEMILASWFRVYTQTMDYLGYKTKLCWTVNRGDELSPVES 219

  Fly   116 ---MVQPMQFYLEFVWLMGGVTLLVLYLYGTLLSENIFGGIYGVISYLMFHSFVAKIYERPLARE 177
               :..|..||:..:::..|..:...|:|||.||.:..||...|:|:...|....::...|..||
 Frog   220 CEGLGDPAYFYVTMIFIWNGAMMFFFYIYGTFLSGSRLGGFLVVLSFFFNHGECTRVMWTPPLRE 284

  Fly   178 NFAFPFIFLQMFYLCICIGRIIHRQRHTSRMFMIFAMSLFTACALLSWQFSTFIFTTQILIMMTS 242
            :|::||:.||||.|     ..|.|.::.||. .:||:.:...|.:|.|||:.|:..|||..:...
 Frog   285 SFSYPFLVLQMFLL-----TYILRAQNVSRQ-SLFALGVSNVCFMLPWQFAQFVLLTQIASLFAI 343

  Fly   243 WNASALPTALVNAF-VLDYSLSHLLGHALAFVMSHGNSQLLLTWQLSISLFLFLITMVRQL---- 302
            :     .|..:|:. .|....:|::...:.|::..|||.||.::..|..:.|.:|....:|
 Frog   344 Y-----ITGFINSSKFLSILYTHMVSLGICFILMFGNSMLLTSYYASSLIVLCVIARNEELFLRL 403

  Fly   303 --RHVRSRRLGHAQDLLNGDLFSLKFLMLTLLLASSVQTTLIELFNRAGVVSVTEGDQQHFFDIC 365
              |||           :...|..|.:::.|:||.:.|...|            ...|..|..::
 Frog   404 QTRHV-----------IFWILHVLSWVVGTVLLKAGVSKLL------------GAADDAHIGNL- 444

  Fly   366 AHWALQVNVGFVAH------LSACNPQYARVAWSELWQLVKTMIVKPYCMYGVVMLAMFFRRWRK 424
                  :...|.|:      :..|..::..:.....|:.:||:::
 Frog   445 ------LKSKFTAYKDFDTLMYTCAAEFDFMERETPWRYLKTLLL-------------------- 483

  Fly   425 SGAPVSALTEEQRERARKYVLEDFIEEHFVSMSDMSSKETEKQLYKCFRLLKSCDYDYERYKRAQ 489
               |:..:.                   |:::              |.:.|
 Frog   484 ---PIVIIV-------------------FIAI--------------CVQAL-------------- 498

  Fly   490 ASLRKEQPPARDDFMQDIKRLRAQINRNSVKQRKERAQETKEAATDGASTPTEEEDKDPEAESES 554
                                                                    :|.:..:.:
 Frog   499 --------------------------------------------------------RDLQISTSA 507

  Fly   555 KKKNQEPGSGETETESAADPTETPPSRSADNEEEEEEHSATAAGCGSNSSGHRQRKRSSSRRSSV 619
            |      |||          .:.||:...       ||||    ||
 Frog   508 K------GSG----------AKNPPNGRL-------EHSA----CG------------------- 526

  Fly   620 VPTANAQILNMHYVYSFLQMLVFTLIGLAVRKL-FFLSFTQGCVIAPTVCSKL---WYHRQ--RN 678
                       ..||..||::.|..:.:.:.:| .||| ...|::|..:|||.   |...:  ::
 Frog   527 -----------ELVYHALQLVAFAALAVLIMRLKLFLS-PHMCIMASLLCSKQLFGWISTRVHQS 579

  Fly   679 IFWSVSLAVFLLSMFDPGMVNIREEYFPTRYSKSGDDLDSMLEWIKLNTERDAVFAGPVDIIGTV 743
            :|  |.:.|.|:|:  .|..|::.:: ..:...|....:.:||||..||...|||||.:..:.:|
 Frog   580 VF--VFIIVGLMSV--QGYSNLQSQW-NIKGEFSNLPQEELLEWIHSNTNPGAVFAGAMPTMASV 639

  Fly   744 HLTTKRPIVNHAHLEMRQIAERTEHVYSVYSRQQSSDIYNQCAQLKIQYLIISLDECTNEVRDDC 808
            .|:|.||||||.|.|...:..||:.|||:|||:.:.::.|....:.:.:.|:....||...:..|
 Frog   640 KLSTGRPIVNHPHYEDTDLRARTKKVYSMYSRKPAKEVKNTLLGMGVDFFILEDTWCTRRTKPGC 704

  Fly   809 DLLAIWDDKQPAYQKYPQFCHELLHKNVPSFLKVFANDHYGIIKMFS 855
            .|..|||.:.|........|..:..::.|.||.||.|   ||.|:.|
 Frog   705 SLPEIWDIEDPENAGKVPLCSMMGKESRPHFLTVFNN---GIYKVLS 748

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG6659	NP_573317.1	Dpy19	17..853	CDD:462945	199/879 (23%)
dpy19l1	XP_031748748.1	Dpy19	90..747	CDD:455131	202/889 (23%)
		putative TM segment 1	90..106	CDD:439130	3/15 (20%)
		putative TM segment 2	226..247	CDD:439130	4/20 (20%)
		putative TM segment 3	251..267	CDD:439130	6/15 (40%)
		putative TM segment 4	287..301	CDD:439130	7/18 (39%)
		putative TM segment 5	310..325	CDD:439130	3/15 (20%)
		putative TM segment 6	331..349	CDD:439130	5/22 (23%)
		putative TM segment 7	357..374	CDD:439130	2/16 (13%)
		putative TM segment 8	377..393	CDD:439130	4/15 (27%)
		putative TM segment 9	411..429	CDD:439130	5/17 (29%)
		putative TM segment 10	481..508	CDD:439130	5/152 (3%)
		putative TM segment 11	532..548	CDD:439130	3/15 (20%)
		putative TM segment 12	552..574	CDD:439130	8/22 (36%)
		putative TM segment 13	578..593	CDD:439130	5/18 (28%)