DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ing3 and PHO23

DIOPT Version :9

Sequence 1:	NP_573316.1	Gene:	Ing3 / 32853	FlyBaseID:	FBgn0030945	Length:	686	Species:	Drosophila melanogaster
Sequence 2:	NP_014302.3	Gene:	PHO23 / 855626	SGDID:	S000005041	Length:	330	Species:	Saccharomyces cerevisiae

Alignment Length:	242	Identity:	58/242 - (23%)
Similarity:	84/242 - (34%)	Gaps:	91/242 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   446 AGGSSTGSHHSHHSQSHHGGHGHGHGHGHGHGHGHGHHSSSGHGGGHSSHH-------------Q 497
            |.....|.|:|  :.:|.........:     :|...|.|..|.|.:::..             :
Yeast   163 AANRRQGEHYS--ASTHQQDDSKNDAN-----YGGSRHESQDHTGNNTNSRKRANAANTNNADPE 220

  Fly   498 EKKQKKKLTTALTLPTVQPTAGSSSGNSIGSSSSISLESVNKLTTSAALAAASATTTYMSVGGQA 562
            .||:|:::.|....|:...||.:.:...||:|           |.|..:::.
Yeast   221 TKKRKRRVATTAVSPSTISTATAVNNGRIGTS-----------TASRGVSSV------------- 261

  Fly   563 LLAMTPGGGGGGNLAESSAEGVPAGMIAMNLPTTTVTPGSSLTIGENGLVVEQTNEGEWSYDPNE 627
                     |..|.:..|.                                .:||      |..|
Yeast   262 ---------GNSNNSRISR--------------------------------PKTN------DYGE 279

  Fly   628 PRYCTCNQVSYGDMVACDNDACPYEWFHYPCVGITQPPKGKWYCPKC 674
            |.||.||||:||:||.||...|..||||.||:|:...|||||||..|
Yeast   280 PLYCYCNQVAYGEMVGCDGADCELEWFHLPCIGLETLPKGKWYCDDC 326

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ing3	NP_573316.1	ING	3..103	CDD:289749
Ing3	NP_573316.1	PHD_ING3	630..674	CDD:277060	27/43 (63%)
PHO23	NP_014302.3	TNG2	5..330	CDD:227367	58/242 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5034
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	106	1.000	Inparanoid score	I1409
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000296
OrthoInspector	1	1.000	-	-		otm46516
orthoMCL	1	0.900	-	-		OOG6_107420
Panther	1	1.100	-	-	O	PTHR10333
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2364
SonicParanoid	1	1.000	-	-		X195
TreeFam	0	0.000	Not matched by this tool.
	9	8.890