DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ing3 and ing3

DIOPT Version :9

Sequence 1:	NP_573316.1	Gene:	Ing3 / 32853	FlyBaseID:	FBgn0030945	Length:	686	Species:	Drosophila melanogaster
Sequence 2:	NP_001008672.1	Gene:	ing3 / 493319	XenbaseID:	XB-GENE-972305	Length:	417	Species:	Xenopus tropicalis

Alignment Length:	684	Identity:	209/684 - (30%)
Similarity:	285/684 - (41%)	Gaps:	269/684 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLYLEDYLEMIEHLPQELRDRFTEMRELDLAVQNNMDSLDKKAHMFFKQCKRDELQHESMDTEFH 65
            ||||||||||||.||.:||||||||||:||.|||.||.|:::...||...|::  :.|..:.:..
Frog     1 MLYLEDYLEMIEQLPMDLRDRFTEMREMDLQVQNAMDQLEQRVGEFFMNAKKN--KPEWREEQMA 63

  Fly    66 SLRGEYFKVMEDADEKVAIATQIHELVERYLRRLDSELFKFKCELEADNNGITEILERRSLELDG 130
            |::.:|||.:|||||||.:|.||::||:|:||:||.||.|||.||||||.||||||||||||||
Frog    64 SIKKDYFKALEDADEKVQLANQIYDLVDRHLRKLDQELAKFKMELEADNAGITEILERRSLELD- 127

  Fly   131 NSTAATALLLSMNQKENRYYGASSANTMVNSSTGHATGAATGSSGIALVSGAAGTGGALSSISTA 195
                      :.:|..|.::                                         :.:.
Frog   128 ----------TPSQPVNNHH-----------------------------------------VHSH 141

  Fly   196 QLGSSQRHRKLEKRRETICTVPVQEKRANLNHSLPVVGSGSTTAAAASSSSATTAAAAASLASAT 260
            .||..::|                  ..:.:||         |....|.....:.|..::|.|..
Frog   142 SLGEKRKH------------------NPSSHHS---------TTDHVSEKKFKSEALLSTLTSDA 179

  Fly   261 TAQTHVSNHIGSIAATHLTLPVAMGVAGGSSSLASSSLATGTGSLVRQLPTNLTHTVLSTSGGAT 325
            :.:                     ..||..::|:|||             ||..:.|
Frog   180 SKE---------------------NTAGCRNNLSSSS-------------TNNVYNV-------- 202

  Fly   326 AAAAAGGNSTSVVAAGTAHGHAHVSGHSAAGATVTYNLQQLGGGAAASSAIAAAASQAIVATQQM 390
                                       :|:....:||:..|..||.| .||..||:||:.||.||
Frog   203 ---------------------------NASQPLTSYNISSLSTGAGA-GAITMAAAQAVQATAQM 239

  Fly   391 QQGRRTASLKASYEAIHGTAGTTTDFWTQAGQGGLQQSTAGSVTVAAGTALATGAAGGSSTGSHH 455
            ::||||:||||||||.     ...||  |.|....:.|...|.:..|.|...| ....::|.|..
Frog   240 KEGRRTSSLKASYEAF-----KNNDF--QLGISLSRDSATYSSSALASTLTQT-LTSSATTDSRS 296

  Fly   456 SHHSQSHHGGHGHGHGHGHGHGHGHGHHSSSGHGGGHSSHHQEKKQKKKLTTALTLPTVQPTAGS 520
            ...|:|:                   :.|:|                            |.::.|
Frog   297 GRKSKSN-------------------NKSAS----------------------------QQSSSS 314

  Fly   521 SSGNSIGSSSSISLESVNKLTTSAALAAASATTTYMSVGGQALLAMTPGGGGGGNLAESSAEGVP 585
            ||.:|:.|.||           |:|||                          ..|:......:|
Frog   315 SSSSSLSSCSS-----------SSALA--------------------------HELSHQQTAAIP 342

  Fly   586 AGMIAMNLPTTTVTPGSSLTIGENGLVVEQTNEGEWSYDPNEPRYCTCNQVSYGDMVACDNDACP 650
            ..                          :..::.:|:|||||||||.|||||||:||.|||..||
Frog   343 ES--------------------------DTNSQVDWTYDPNEPRYCICNQVSYGEMVGCDNQDCP 381

  Fly   651 YEWFHYPCVGITQPPKGKWYCPKCTASMRRRGNR 684
            .|||||.|||:::.||||||||:|||:|:|||:|
Frog   382 IEWFHYGCVGLSEAPKGKWYCPQCTAAMKRRGSR 415

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ing3	NP_573316.1	ING	3..103	CDD:289749	55/99 (56%)
Ing3	NP_573316.1	PHD_ING3	630..674	CDD:277060	32/43 (74%)
ing3	NP_001008672.1	ING	3..102	CDD:404028	56/100 (56%)
		TNG2	4..409	CDD:227367	201/673 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	126..165		11/117 (9%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	177..198		8/54 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	284..320		11/83 (13%)
		PHD_ING3	361..405	CDD:277060	32/43 (74%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	185	1.000	Domainoid score	I3322
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	304	1.000	Inparanoid score	I2615
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1434088at2759
OrthoFinder	1	1.000	-	-		FOG0000296
OrthoInspector	1	1.000	-	-		otm49288
Panther	1	1.100	-	-	LDO	PTHR10333
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2364
SonicParanoid	1	1.000	-	-		X195
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	10.190