Protein Alignment Ing3 and Ing3

DIOPT Version :10

• Sequence 1: NP_573316.1
• Gene: Ing3 / 32853
• FlyBaseID: FBgn0030945
• Length: 686
• Species: Drosophila melanogaster
• Sequence 2: NP_001029279.1
• Gene: Ing3 / 312154
• RGDID: 1310556
• Length: 421
• Species: Rattus norvegicus
• Alignment Length: 690
• Identity: 214/690 - (31%)
• Similarity: 288/690 - (41%)
• Gaps: 277/690 - (40%)

  Fly     1 MLYLEDYLEMIEHLPQELRDRFTEMRELDLAVQNNMDSLDKKAHMFFKQCKRDELQHESMDTEFH 65
            ||||||||||||.||.:||||||||||:||.|||.||.|:::...||...|::  :.|..:.:..
  Rat     1 MLYLEDYLEMIEQLPMDLRDRFTEMREMDLQVQNAMDQLEQRVSEFFMNAKKN--KPEWREEQMA 63

  Fly    66 SLRGEYFKVMEDADEKVAIATQIHELVERYLRRLDSELFKFKCELEADNNGITEILERRSLELDG 130
            |::.:|:|.:|||||||.:|.||::||:|:||:||.||.|||.||||||.||||||||||||||.
  Rat    64 SIKKDYYKALEDADEKVQLANQIYDLVDRHLRKLDQELAKFKMELEADNAGITEILERRSLELDA 128

  Fly   131 NSTAATALLLSMNQKENRYYGASSANTMVNSSTGHATGAATGSSGIALVSGAAGTGGALSSISTA 195
            .|..                        ||:...|:
  Rat   129 PSQP------------------------VNNHHAHS----------------------------- 140

  Fly   196 QLGSSQRHRKLEKRR-----ETICTVPVQEKRANLNHSLPVVGSGSTTAAAASSSSATTAAAAAS 255
                   |..:|||:     ....|..:.||:..                            :.:
  Rat   141 -------HTPVEKRKYNPTSHHTATDHIPEKKFK----------------------------SEA 170

  Fly   256 LASATTAQTHVSNHIGSIAATHLTLPVAMGVAGGSSSLASSSLATGTGSLVRQLPTNLTHTVLST 320
            |.|..|:.....|.:|               ...::|.||.:.|...
  Rat   171 LLSTLTSDASKENTLG---------------CRNNNSTASCNNAYNV------------------ 202

  Fly   321 SGGATAAAAAGGNSTSVVAAGTAHGHAHVSGHSAAGATVTYNLQQLGGGAAASSAIAAAASQAIV 385
                        ||:..:|                    :||:..|..||.| .||..||:||:.
  Rat   203 ------------NSSQPLA--------------------SYNIGSLSSGAGA-GAITMAAAQAVQ 234

  Fly   386 ATQQMQQGRRTASLKASYEAIHGTAGTTTDFWTQAG-QGGLQQSTAGSVTVAAGTALATGAAGGS 449
            ||.||::||||:||||||||.     ...||  |.| :..:.:.|||   .::.:||.|.....:
  Rat   235 ATAQMKEGRRTSSLKASYEAF-----KNNDF--QLGKEFSMPRETAG---YSSSSALMTTLTQNA 289

  Fly   450 STGSHHSHHSQSHHGGHGHGHGHGHGHGHGHGHHSSSGHGGGHSSHHQEKKQKKKLTTALTLPTV 514
            |:                                |::....|..|.:..|...::
  Rat   290 SS--------------------------------SAADSRSGRKSKNNTKSSSQQ---------- 312

  Fly   515 QPTAGSSSGNSIGSSSSISLESVNKLTTSAALAAASATTTYMSVGGQALLAMTPGGGGGGNLAES 579
                 |||.:|..||||:||             .:|::|....|..|
  Rat   313 -----SSSSSSSSSSSSLSL-------------CSSSSTVVQEVSQQ------------------ 341

  Fly   580 SAEGVPAGMIAMNLPTTTVTPGSSLTIGENGLVVEQTNEGEWSYDPNEPRYCTCNQVSYGDMVAC 644
                            |||.|.|           :..::.:|:|||||||||.|||||||:||.|
  Rat   342 ----------------TTVVPES-----------DSNSQVDWTYDPNEPRYCICNQVSYGEMVGC 379

  Fly   645 DNDACPYEWFHYPCVGITQPPKGKWYCPKCTASMRRRGNR 684
            ||..||.|||||.|||:|:.|||||:||:|||:|:|||:|
  Rat   380 DNQDCPIEWFHYGCVGLTEAPKGKWFCPQCTAAMKRRGSR 419

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ing3	NP_573316.1	ING	3..103	CDD:463768	54/99 (55%)
		PHD_ING3	630..674	CDD:277060	32/43 (74%)
Ing3	NP_001029279.1	ING	3..102	CDD:463768	54/98 (55%)
		TNG2	4..413	CDD:227367	129/413 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	129..164		4/34 (12%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	286..324		4/37 (11%)
		PHD_ING3	365..409	CDD:277060	26/43 (60%)