DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ing3 and Ing1

DIOPT Version :9

Sequence 1:	NP_573316.1	Gene:	Ing3 / 32853	FlyBaseID:	FBgn0030945	Length:	686	Species:	Drosophila melanogaster
Sequence 2:	XP_038950529.1	Gene:	Ing1 / 306626	RGDID:	1306330	Length:	396	Species:	Rattus norvegicus

Alignment Length:	455	Identity:	107/455 - (23%)
Similarity:	155/455 - (34%)	Gaps:	111/455 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   235 GSTTAAAASSSSATTAAAAASLASATTAQTHVSNHIGSIAAT-HLTLPVAMGVAGGSSSLASSSL 298
            |:......:.:.|.:.||...|.|........: |:.|..:| |   |....::.|.|.|.:...
  Rat    15 GARNLLRVARTRAASGAAGEELGSGKRCSRQPA-HLRSPRSTEH---PSGAPLSTGHSKLCTGRR 75

  Fly   299 ATGTGSLVRQLPTNLTHTVLSTSGGATAAAAAGGNSTSVVAAGTAHGHAHVSGHSAAGATVTYNL 363
            ..||..              :...||.:|..||....|......:....|.|..|.|.|..:.:|
  Rat    76 HKGTEG--------------AKGAGAGSAEDAGSGGLSARRWRPSRAGPHPSPGSCACAPTSASL 126

  Fly   364 QQLGGGAAASSAIAAAASQAIVATQ----------QMQQGRR--TASLKASYEAI-HGTAGTTTD 415
                  ..|.||:....|..::..:          .:|.|||  ...|...||.. ..|..|...
  Rat   127 ------GPARSALLEEDSSLVLGVRGALPVPPHLLLVQIGRREILKELDDYYEKFKRETDSTQKR 185

  Fly   416 FWTQAGQGGLQQS-TAGSVTVAAGTALATGAAGGSSTGSHHSHHSQSHHGGHGHGHGHGHGHGHG 479
            ......|..|.:| ..|...:...:.:.......|.....|....::|
  Rat   186 RVLHCIQRALIRSQELGDEKIQIVSQMVELVENRSRQVDSHVELFEAH----------------- 233

  Fly   480 HGHHSSSGHGGGHSSHHQEKKQKKKLTTALTLPTVQPTAGSSSGNSIGSSSSISLESVNKLTTSA 544
              ...|.|.|||..: .|:|.:.:.:|.|......:.....::.|...:|::...:.:    ||.
  Rat   234 --QDISDGTGGGGKA-GQDKSKSEAITQADKPNNKRSRRQRNNENRENASNNHDHDDI----TSG 291

  Fly   545 ALAAASATTTYMSVGGQALLAMTPGGGGGGNLAESSAEGVPAGMIAMNLPTTTVTPGSSLTIGEN 609
            ......|.|:......:               |::..|..||     :||
  Rat   292 TPKEKKAKTSKKKKRSK---------------AKAEREASPA-----DLP--------------- 321

  Fly   610 GLVVEQTNEGEWSYDPNEPRYCTCNQVSYGDMVACDNDACPYEWFHYPCVGITQPPKGKWYCPKC 674
                         .|||||.||.|||||||:|:.||||.||.||||:.|||:...||||||||||
  Rat   322 -------------IDPNEPTYCLCNQVSYGEMIGCDNDECPIEWFHFSCVGLNHKPKGKWYCPKC 373

Fly 675 674
Rat 374 373

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ing3	NP_573316.1	ING	3..103	CDD:289749
Ing3	NP_573316.1	PHD_ING3	630..674	CDD:277060	31/43 (72%)
Ing1	XP_038950529.1	ING	<162..224	CDD:355795	11/61 (18%)
Ing1	XP_038950529.1	PHD_ING1_2	329..373	CDD:277059	31/43 (72%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5034
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1434088at2759
OrthoFinder	1	1.000	-	-		FOG0000296
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X195
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.820