Protein Alignment Hou and GID8

DIOPT Version :10

• Sequence 1: NP_573315.1
• Gene: Hou / 32852
• FlyBaseID: FBgn0030944
• Length: 225
• Species: Drosophila melanogaster
• Sequence 2: NP_060366.1
• Gene: GID8 / 54994
• HGNCID: 15857
• Length: 228
• Species: Homo sapiens
• Alignment Length: 229
• Identity: 133/229 - (58%)
• Similarity: 172/229 - (75%)
• Gaps: 5/229 - (2%)

  Fly     1 MSYNEKSEAIIKEEWLQRLEQFPFKQADMNRLIMNYLVTEGFKEAAEKFQHEADLEPSVELSSLD 65
            |||.||.:.|.|:||:::|.....::|||||||||||||||||||||||:.|:.:||||:|.:||
Human     1 MSYAEKPDEITKDEWMEKLNNLHVQRADMNRLIMNYLVTEGFKEAAEKFRMESGIEPSVDLETLD 65

  Fly    66 GRILIREAVQAGRIEEATQLVNQLHPELLGSDRYLFFHLQQLQLIELIRAGKVEEALSFAQSKLS 130
            .||.|||.:..|:|:||..|:|.||||||.::|||:|||||..||||||..:.|.||.|||::|:
Human    66 ERIKIREMILKGQIQEAIALINSLHPELLDTNRYLYFHLQQQHLIELIRQRETEAALEFAQTQLA 130

  Fly   131 ESGEEA---MFELERTLALLAFEKPQESPFADLLEQSYRQKIASELNSAILRCEQSEDSTPKMMF 192
            |.|||:   :.|:|||||||||:.|:||||.|||....|||:.||:|.|:|..|..| ||||:..
Human   131 EQGEESRECLTEMERTLALLAFDSPEESPFGDLLHTMQRQKVWSEVNQAVLDYENRE-STPKLAK 194

  Fly   193 LLKLILWAQSKLDSRSISYPKMKNLETAHL-EPK 225
            ||||:||||::||.:.:.||||.:|....: |||
Human   195 LLKLLLWAQNELDQKKVKYPKMTDLSKGVIEEPK 228

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hou	NP_573315.1	LisH	28..52	CDD:462501	22/23 (96%)
		CTLH	67..205	CDD:402305	82/140 (59%)
GID8	NP_060366.1	LisH	28..52	CDD:462501	22/23 (96%)
		CTLH	63..207	CDD:402305	84/144 (58%)
		Interaction with CTNNB1. /evidence=ECO:0000269|PubMed:28829046	116..212		53/96 (55%)