Protein Alignment Nup35 and NUP35

DIOPT Version :10

• Sequence 1: NP_573314.1
• Gene: Nup35 / 32851
• FlyBaseID: FBgn0030943
• Length: 331
• Species: Drosophila melanogaster
• Sequence 2: XP_016858797.1
• Gene: NUP35 / 129401
• HGNCID: 29797
• Length: 329
• Species: Homo sapiens
• Alignment Length: 356
• Identity: 103/356 - (28%)
• Similarity: 156/356 - (43%)
• Gaps: 71/356 - (19%)

  Fly     2 EPMNLGSPVN-SPGSNQTQYLPPFLLGD-PQGITPHKNTLS-PKTGRSNISFATSPGGSSPHELN 63
            |||.||||.: .||.| .|:||.||:|| |..:||...::| |..|...:......|||.|..:
Human    19 EPMMLGSPTSPKPGVN-AQFLPGFLMGDLPAPVTPQPRSISGPSVGVMEMRSPLLAGGSPPQPV- 81

  Fly    64 RSALSTRTLFAAQGGAHTAVGANSSTTAHGQTHSHHQTGPPTQGLFDSLREQSV--TPKKKNHLG 126
                               |.|          |......||.:.::|.:....:  ||
Human    82 -------------------VPA----------HKDKSGAPPVRSIYDDISSPGLGSTP------- 110

  Fly   127 MLQLQSPNQSYQSSYHTNDSFAPG------APNAINASMRALCSPLGATASPAGGLGTSVTTGGN 185
            :...:.||.|...|.....:..||      :|.:|....:...||  |...|....|.|:|:  .
Human   111 LTSRRQPNISVMQSPLVGVTSTPGTGQSMFSPASIGQPRKTTLSP--AQLDPFYTQGDSLTS--E 171

  Fly   186 SRLSDFWVTIFGFPPGAGSMVLQHFTVCGTIVDVVHAPQN-GNWMYVRYSSRIESDKALNYNEKI 249
            ..|.|.|||:||||..:.|.:|..|...|.|:.  |...| ||||::||.|::::.|||:.:.:|
Human   172 DHLDDSWVTVFGFPQASASYILLQFAQYGNILK--HVMSNTGNWMHIRYQSKLQARKALSKDGRI 234

  Fly   250 IAGNVMVGVSRCTDRSVIDKE--------NIGSVPNAEIGDPPTSP------SAIRPFSQQSYKL 300
            ...::|:||..|.|:||::..        ::...|..:....||.|      |.:||.: .:||.
Human   235 FGESIMIGVKPCIDKSVMESSDRCALSSPSLAFTPPIKTLGTPTQPGSTPRISTMRPLA-TAYKA 298

  Fly   301 ARKDNIISPQKDVPQKSSGLMDKAMDLIFGW 331
            :..|..:...:..|:|...|:.|||:.:|||
Human   299 STSDYQVISDRQTPKKDESLVSKAMEYMFGW 329

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nup35	NP_573314.1	Nup35_RRM	190..268	CDD:398713	33/78 (42%)
NUP35	XP_016858797.1	RRM_Nup53	175..248	CDD:410121	30/74 (41%)